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Submitochondrial Calpains in Pathophysiological Consequences

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Proteases in Physiology and Pathology

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Abstract

It has now been well established that different mitochondrial compartments contain varieties of calpains. The expression levels of these calpains are tissue and cell type specific. Although, mitochondrial compartments contain different types of calpains, the precise location within mitochondria and their functions remain imprecise. The aim of the present review is to confer information concerning the localization of calpains in different mitochondrial compartments affiliated with their function, particularly in pathophysiological conditions. For instance, mitochondrial μ-calpain is located within the inner membrane, intermembrane space, and mitochondrial matrix depending on cell types. μ-Calpain activity facilitates cleavage of apoptosis-inducing factor (AIF) within inner membrane and intermembrane space, while the activated μ-calpain within matrix is associated with cleavage of complex I subunits and metabolic enzymes. Understandably, inhibition of the μ-calpain could be a potential strategy to ameliorate ischemia–reperfusion-associated injuries.

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Acknowledgment

Financial assistance from the DST-PURSE program of the University of Kalyani is acknowledged.

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Authors and Affiliations

  1. Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK

    Pulak Kar & Krishna Samanta

  2. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, 741235, West Bengal, India

    Tapati Chakraborti, Md Nur Alam & Sajal Chakraborti

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  1. Pulak Kar
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  2. Krishna Samanta
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  3. Tapati Chakraborti
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  4. Md Nur Alam
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  5. Sajal Chakraborti
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Correspondence to Sajal Chakraborti .

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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. St. Boniface Hospital Research Centre, University of Manitoba, Faculty of Health Sciences, College of Medicine, Institute of Cardiovascular Sciences, Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla

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Kar, P., Samanta, K., Chakraborti, T., Alam, M.N., Chakraborti, S. (2017). Submitochondrial Calpains in Pathophysiological Consequences. In: Chakraborti, S., Dhalla, N. (eds) Proteases in Physiology and Pathology. Springer, Singapore. https://doi.org/10.1007/978-981-10-2513-6_17

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