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Mental Health and Illness of the Elderly pp 85–104Cite as

(Neurobiology of) Dementia: Causes, Presentation, and Management

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Part of the book series: Mental Health and Illness Worldwide ((MHIW))

Abstract

Alzheimer’s disease is the main type of dementia in aging populations and is characterized by a progressive impairment in cognitive abilities associated with behavioral and psychological changes and a progressive loss of autonomy. Other dementia syndromes in aging can, however, be observed but their frequency is lower. The present chapter will describe the clinical course and aetiologies of the main dementia syndromes in elderly populations as well as the main therapeutic options for the management of dementia.

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References

  • Aarsland D, Kurz MW (2010) The epidemiology of dementia associated with Parkinson disease. J Neurol Sci 289(1–2):18–22

    Article  PubMed  Google Scholar 

  • Abbott RD, White LR, Ross GW, Masaki KH, Curb JD, Petrovitch H (2004) Walking and dementia in physically capable elderly men. JAMA 292(12):1447–1453

    Article  CAS  PubMed  Google Scholar 

  • Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH (2011) The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7(3):270–279

    Article  PubMed  PubMed Central  Google Scholar 

  • APA (2013) DSM-V: Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Association, Arlington

    Google Scholar 

  • Baldi I, Lebailly P, Mohammed-Brahim B, Letenneur L, Dartigues JF, Brochard P (2003) Neurodegenerative diseases and exposure to pesticides in the elderly. Am J Epidemiol 157(5):409–414

    Article  PubMed  Google Scholar 

  • Bennett DA, Schneider JA, Tang Y, Arnold SE, Wilson RS (2006) The effect of social networks on the relation between Alzheimer’s disease pathology and level of cognitive function in old people: a longitudinal cohort study. Lancet Neurol 5(5):406–412

    Article  PubMed  Google Scholar 

  • Ben-Sadoun G, Sacco G, Manera V, Bourgeois J, Konig A, Foulon P, Fosty B, Bremond F, d’Arripe-Longueville F, Robert P (2016) Physical and cognitive stimulation using an exergame in subjects with normal aging, mild and moderate cognitive impairment. J Alzheimers Dis 53(4):1299–1314

    Article  PubMed  Google Scholar 

  • Bian L, Yang JD, Guo TW, Sun Y, Duan SW, Chen WY, Pan YX, Feng GY, He L (2004) Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese. Neurology 63(2):241–245

    Article  CAS  PubMed  Google Scholar 

  • Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P (2006) Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol 5(1):64–74

    Article  PubMed  Google Scholar 

  • Boeve BF (2011) The multiple phenotypes of corticobasal syndrome and corticobasal degeneration: implications for further study. J Mol Neurosci 45(3):350–353

    Article  CAS  PubMed  Google Scholar 

  • Bonnechere B, Jansen B, Omelina L, Van Sint Jan S (2016) The use of commercial video games in rehabilitation: a systematic review. Int J Rehabil Res 39(4):277–290

    Article  PubMed  Google Scholar 

  • Brunnstrom H, Gustafson L, Passant U, Englund E (2009) Prevalence of dementia subtypes: a 30-year retrospective survey of neuropathological reports. Arch Gerontol Geriatr 49(1):146–149

    Article  PubMed  Google Scholar 

  • Cummings JL (1997) The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. Neurology 48(5 Suppl 6):S10–S16

    Article  CAS  PubMed  Google Scholar 

  • de Oliveira AM, Radanovic M, de Mello PC, Buchain PC, Vizzotto AD, Celestino DL, Stella F, Piersol CV, Forlenza OV (2015) Nonpharmacological interventions to reduce behavioral and psychological symptoms of dementia: a systematic review. Biomed Res Int 2015:218980

    PubMed  PubMed Central  Google Scholar 

  • den Heijer T, Vermeer SE, van Dijk EJ, Prins ND, Koudstaal PJ, Hofman A, Breteler MM (2003) Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI. Diabetologia 46(12):1604–1610

    Article  Google Scholar 

  • De-Paula VJ, Radanovic M, Diniz BS, Forlenza OV (2012) Alzheimer’s disease. Subcell Biochem 65:329–352

    Article  CAS  PubMed  Google Scholar 

  • Dubois B, Feldman HH, Jacova C, Cummings JL, Dekosky ST, Barberger-Gateau P, Delacourte A, Frisoni G, Fox NC, Galasko D, Gauthier S, Hampel H, Jicha GA, Meguro K, O’Brien J, Pasquier F, Robert P, Rossor M, Salloway S, Sarazin M, de Souza LC, Stern Y, Visser PJ, Scheltens P (2010) Revising the definition of Alzheimer’s disease: a new lexicon. Lancet Neurol 9(11):1118–1127

    Article  PubMed  Google Scholar 

  • Dubois B, Feldman HH, Jacova C, Hampel H, Molinuevo JL, Blennow K, DeKosky ST, Gauthier S, Selkoe D, Bateman R, Cappa S, Crutch S, Engelborghs S, Frisoni GB, Fox NC, Galasko D, Habert MO, Jicha GA, Nordberg A, Pasquier F, Rabinovici G, Robert P, Rowe C, Salloway S, Sarazin M, Epelbaum S, de Souza LC, Vellas B, Visser PJ, Schneider L, Stern Y, Scheltens P, Cummings JL (2014) Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria. Lancet Neurol 13(6):614–629

    Article  PubMed  Google Scholar 

  • Duyckaerts C, Hauw JJ (2003) Lewy bodies, a misleading marker for Parkinson’s disease? Bull Acad Natl Med 187(2):277–292. discussion 292-273

    CAS  PubMed  Google Scholar 

  • Engelhart MJ, Geerlings MI, Ruitenberg A, van Swieten JC, Hofman A, Witteman JC, Breteler MM (2002) Dietary intake of antioxidants and risk of Alzheimer disease. JAMA 287(24):3223–3229

    Article  CAS  PubMed  Google Scholar 

  • Fleminger S, Oliver DL, Lovestone S, Rabe-Hesketh S, Giora A (2003) Head injury as a risk factor for Alzheimer’s disease: the evidence 10 years on; a partial replication. J Neurol Neurosurg Psychiatry 74(7):857–862

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fratiglioni L, Paillard-Borg S, Winblad B (2004) An active and socially integrated lifestyle in late life might protect against dementia. Lancet Neurol 3(6):343–353

    Article  PubMed  Google Scholar 

  • Gitlin LN, Kales HC, Lyketsos CG (2012) Nonpharmacologic management of behavioral symptoms in dementia. JAMA 308(19):2020–2029

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Goodman RA, Lochner KA, Thambisetty M, Wingo TS, Posner SF, Ling SM (2016) Prevalence of dementia subtypes in U.S. Medicare fee-for-service beneficiaries, 2011–2013. Alzheimers Dement 13(1):28–37

    Google Scholar 

  • Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, Launer LJ, Laurent S, Lopez OL, Nyenhuis D, Petersen RC, Schneider JA, Tzourio C, Arnett DK, Bennett DA, Chui HC, Higashida RT, Lindquist R, Nilsson PM, Roman GC, Sellke FW, Seshadri S, C. o. E. American Heart Association Stroke Council, C. o. C. N. C. o. C. R. Prevention, Intervention, S. Council on Cardiovascular and Anesthesia (2011) Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke 42(9):2672–2713

    Article  PubMed  PubMed Central  Google Scholar 

  • Gorno-Tempini ML, Brambati SM, Ginex V, Ogar J, Dronkers NF, Marcone A, Perani D, Garibotto V, Cappa SF, Miller BL (2008) The logopenic/phonological variant of primary progressive aphasia. Neurology 71(16):1227–1234

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gorno-Tempini ML, Hillis AE, Weintraub S, Kertesz A, Mendez M, Cappa SF, Ogar JM, Rohrer JD, Black S, Boeve BF, Manes F, Dronkers NF, Vandenberghe R, Rascovsky K, Patterson K, Miller BL, Knopman DS, Hodges JR, Mesulam MM, Grossman M (2011) Classification of primary progressive aphasia and its variants. Neurology 76(11):1006–1014

    Article  PubMed  PubMed Central  Google Scholar 

  • Gray SL, Anderson ML, Dublin S, Hanlon JT, Hubbard R, Walker R, Yu O, Crane PK, Larson EB (2015) Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study. JAMA Intern Med 175(3):401–407

    Article  PubMed  PubMed Central  Google Scholar 

  • Gros A, Bensamoun D, Manera V, Fabre R, Zacconi-Cauvin A, Thummler S, Benoit M, Robert P, David R (2016) Recommendations for the use of ICT in elderly populations with affective disorders. Front Aging Neurosci 8(269)

    Google Scholar 

  • Grossman M (2012) The non-fluent/agrammatic variant of primary progressive aphasia. Lancet Neurol 11(6):545–555

    Article  PubMed  PubMed Central  Google Scholar 

  • Heude B, Ducimetiere P, Berr C, Study EVA (2003) Cognitive decline and fatty acid composition of erythrocyte membranes–The EVA Study. Am J Clin Nutr 77(4):803–808

    CAS  PubMed  Google Scholar 

  • Huey ED, Putnam KT, Grafman J (2006) A systematic review of neurotransmitter deficits and treatments in frontotemporal dementia. Neurology 66(1):17–22

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Incalzi RA, Gemma A, Marra C, Capparella O, Fuso L, Carbonin P (1997) Verbal memory impairment in COPD: its mechanisms and clinical relevance. Chest 112(6):1506–1513

    Article  CAS  PubMed  Google Scholar 

  • Jack CR Jr, Knopman DS, Jagust WJ, Petersen RC, Weiner MW, Aisen PS, Shaw LM, Vemuri P, Wiste HJ, Weigand SD, Lesnick TG, Pankratz VS, Donohue MC, Trojanowski JQ (2013) Tracking pathophysiological processes in Alzheimer’s disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol 12(2):207–216

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jansen WJ, Handels RL, Visser PJ, Aalten P, Bouwman F, Claassen J, van Domburg P, Hoff E, Hoogmoed J, Leentjens AF, Rikkert MO, Oleksik AM, Smid M, Scheltens P, Wolfs C, Verhey F, Ramakers IH (2016) The diagnostic and prognostic value of neuropsychological assessment in memory clinic patients. J Alzheimers Dis 55(2):679–689

    Google Scholar 

  • Jellinger KA (2008) Morphologic diagnosis of “vascular dementia” – a critical update. J Neurol Sci 270(1-2):1–12

    Article  PubMed  Google Scholar 

  • Kalaria RN, Maestre GE, Arizaga R, Friedland RP, Galasko D, Hall K, Luchsinger JA, Ogunniyi A, Perry EK, Potocnik F, Prince M, Stewart R, Wimo A, Zhang ZX, Antuono P, G. World Federation of Neurology Dementia Research (2008) Alzheimer’s disease and vascular dementia in developing countries: prevalence, management, and risk factors. Lancet Neurol 7(9):812–826

    Article  PubMed  PubMed Central  Google Scholar 

  • Kales HC, Gitlin LN, Lyketsos CG (2015) Assessment and management of behavioral and psychological symptoms of dementia. BMJ 350:h369

    Article  PubMed  PubMed Central  Google Scholar 

  • Kortte KB, Rogalski EJ (2013) Behavioural interventions for enhancing life participation in behavioural variant frontotemporal dementia and primary progressive aphasia. Int Rev Psychiatry 25(2):237–245

    Article  PubMed  PubMed Central  Google Scholar 

  • Kurz A, Kurz C, Ellis K, Lautenschlager NT (2014) What is frontotemporal dementia? Maturitas 79(2):216–219

    Article  PubMed  Google Scholar 

  • Letenneur L, Gilleron V, Commenges D, Helmer C, Orgogozo JM, Dartigues JF (1999) Are sex and educational level independent predictors of dementia and Alzheimer’s disease? Incidence data from the PAQUID project. J Neurol Neurosurg Psychiatry 66(2):177–183

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ling H (2016) Clinical approach to progressive supranuclear palsy. J Mov Disord 9(1):3–13

    Article  PubMed  PubMed Central  Google Scholar 

  • Ling H, O’Sullivan SS, Holton JL, Revesz T, Massey LA, Williams DR, Paviour DC, Lees AJ (2010) Does corticobasal degeneration exist? A clinicopathological re-evaluation. Brain 133(Pt 7):2045–2057

    Article  PubMed  Google Scholar 

  • Litvan I, Agid Y, Calne D, Campbell G, Dubois B, Duvoisin RC, Goetz CG, Golbe LI, Grafman J, Growdon JH, Hallett M, Jankovic J, Quinn NP, Tolosa E, Zee DS (1996) Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop. Neurology 47(1):1–9

    Article  CAS  PubMed  Google Scholar 

  • Luchsinger JA, Tang MX, Miller J, Green R, Mayeux R (2007) Relation of higher folate intake to lower risk of Alzheimer disease in the elderly. Arch Neurol 64(1):86–92

    Article  PubMed  Google Scholar 

  • Lumsden J, Edwards EA, Lawrence NS, Coyle D, Munafo MR (2016) Gamification of cognitive assessment and cognitive training: a systematic review of applications and efficacy. JMIR Serious Games 4(2):e11

    Article  PubMed  PubMed Central  Google Scholar 

  • Lyketsos CG, Steinberg M, Tschanz JT, Norton MC, Steffens DC, Breitner JC (2000) Mental and behavioral disturbances in dementia: findings from the cache county study on memory in aging. Am J Psychiatry 157(5):708–714

    Article  CAS  PubMed  Google Scholar 

  • Magnin E, Teichmann M, Martinaud O, Moreaud O, Ryff I, Belliard S, Pariente J, Moulin T, Vandel P, Demonet JF (2015) Specificities of the logopenic variant of primary progressive aphasia. Rev Neurol (Paris) 171(1):16–30

    Article  CAS  Google Scholar 

  • Manera V, Petit PD, Derreumaux A, Orvieto I, Romagnoli M, Lyttle G, David R, Robert PH (2015) ‘Kitchen and cooking,’ a serious game for mild cognitive impairment and Alzheimer’s disease: a pilot study. Front Aging Neurosci 7:24

    Article  PubMed  PubMed Central  Google Scholar 

  • McKeith I (2004) Dementia with Lewy bodies. Dialogues Clin Neurosci 6(3):333–341

    PubMed  PubMed Central  Google Scholar 

  • McKeith IG, Dickson DW, Lowe J, Emre M, O’Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VM, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M (2005) Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 65(12):1863–1872

    Article  CAS  PubMed  Google Scholar 

  • McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, Mohs RC, Morris JC, Rossor MN, Scheltens P, Carrillo MC, Thies B, Weintraub S, Phelps CH (2011) The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7(3):263–269

    Article  PubMed  PubMed Central  Google Scholar 

  • Mesulam MM (2001) Primary progressive aphasia. Ann Neurol 49(4):425–432

    Article  CAS  PubMed  Google Scholar 

  • Morris JC, Blennow K, Froelich L, Nordberg A, Soininen H, Waldemar G, Wahlund LO, Dubois B (2014) Harmonized diagnostic criteria for Alzheimer’s disease: recommendations. J Intern Med 275(3):204–213

    Article  CAS  PubMed  Google Scholar 

  • O’Brien JT, Burns A (2011) Clinical practice with anti-dementia drugs: a revised (second) consensus statement from the British Association for Psychopharmacology. J Psychopharmacol 25(8):997–1019

    Article  PubMed  Google Scholar 

  • O’Brien JT, Thomas A (2015) Vascular dementia. Lancet 386(10004):1698–1706

    Article  PubMed  Google Scholar 

  • Ott A, Andersen K, Dewey ME, Letenneur L, Brayne C, Copeland JR, Dartigues JF, Kragh-Sorensen P, Lobo A, Martinez-Lage JM, Stijnen T, Hofman A, Launer LJ, E. I. R. Group (2004) Effect of smoking on global cognitive function in nondemented elderly. Neurology 62(6):920–924

    Article  CAS  PubMed  Google Scholar 

  • Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E (1999) Mild cognitive impairment: clinical characterization and outcome. Arch Neuro 56:303–308

    Article  CAS  Google Scholar 

  • Petrovitch H, White LR, Izmirilian G, Ross GW, Havlik RJ, Markesbery W, Nelson J, Davis DG, Hardman J, Foley DJ, Launer LJ (2000) Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS. Honolulu-Asia aging Study. Neurobiol Aging 21(1):57–62

    Article  CAS  PubMed  Google Scholar 

  • Plassman BL, Havlik RJ, Steffens DC, Helms MJ, Newman TN, Drosdick D, Phillips C, Gau BA, Welsh-Bohmer KA, Burke JR, Guralnik JM, Breitner JC (2000) Documented head injury in early adulthood and risk of Alzheimer’s disease and other dementias. Neurology 55(8):1158–1166

    Article  CAS  PubMed  Google Scholar 

  • Press-Sandler O, Freud T, Volkov I, Peleg R, Press Y (2016) Aromatherapy for the treatment of patients with behavioral and psychological symptoms of dementia: a descriptive analysis of RCTs. J Altern Complement Med 22(6):422–428

    Article  PubMed  Google Scholar 

  • Qiu C, Winblad B, Fratiglioni L (2005) The age-dependent relation of blood pressure to cognitive function and dementia. Lancet Neurol 4(8):487–499

    Article  PubMed  Google Scholar 

  • Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, van Swieten JC, Seelaar H, Dopper EG, Onyike CU, Hillis AE, Josephs KA, Boeve BF, Kertesz A, Seeley WW, Rankin KP, Johnson JK, Gorno-Tempini ML, Rosen H, Prioleau-Latham CE, Lee A, Kipps CM, Lillo P, Piguet O, Rohrer JD, Rossor MN, Warren JD, Fox NC, Galasko D, Salmon DP, Black SE, Mesulam M, Weintraub S, Dickerson BC, Diehl-Schmid J, Pasquier F, Deramecourt V, Lebert F, Pijnenburg Y, Chow TW, Manes F, Grafman J, Cappa SF, Freedman M, Grossman M, Miller BL (2011) Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 134(Pt 9):2456–2477

    Article  PubMed  PubMed Central  Google Scholar 

  • Ravaglia G, Forti P, Maioli F, Martelli M, Servadei L, Brunetti N, Porcellini E, Licastro F (2005) Homocysteine and folate as risk factors for dementia and Alzheimer disease. Am J Clin Nutr 82(3):636–643

    CAS  PubMed  Google Scholar 

  • Reese TR, Thiel DJ, Cocker KE (2016) Behavioral disorders in dementia: appropriate nondrug interventions and antipsychotic use. Am Fam Physician 94(4):276–282

    PubMed  Google Scholar 

  • Reppas-Rindlisbacher CE, Fischer HD, Fung K, Gill SS, Seitz D, Tannenbaum C, Austin PC, Rochon PA (2016) Anticholinergic drug burden in persons with dementia taking a cholinesterase inhibitor: the effect of multiple physicians. J Am Geriatr Soc 64(3):492–500

    Article  PubMed  PubMed Central  Google Scholar 

  • Robert PH, Konig A, Andrieu S, Bremond F, Chemin I, Chung PC, Dartigues JF, Dubois B, Feutren G, Guillemaud R, Kenisberg PA, Nave S, Vellas B, Verhey F, Yesavage J, Mallea P (2013) Recommendations for ICT use in Alzheimer’s disease assessment: Monaco CTAD expert meeting. J Nutr Health Aging 17(8):653–660

    Article  CAS  PubMed  Google Scholar 

  • Roman GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, Amaducci L, Orgogozo JM, Brun A, Hofman A et al (1993) Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology 43(2):250–260

    Article  CAS  PubMed  Google Scholar 

  • Rondeau V (2002) A review of epidemiologic studies on aluminum and silica in relation to Alzheimer’s disease and associated disorders. Rev Environ Health 17(2):107–121

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rondeau V, Commenges D, Jacqmin-Gadda H, Dartigues JF (2000) Relation between aluminum concentrations in drinking water and Alzheimer’s disease: an 8-year follow-up study. Am J Epidemiol 152(1):59–66

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Saczynski JS, Pfeifer LA, Masaki K, Korf ES, Laurin D, White L, Launer LJ (2006) The effect of social engagement on incident dementia: the Honolulu-Asia aging study. Am J Epidemiol 163(5):433–440

    Article  PubMed  Google Scholar 

  • Sambamurti K, Granholm AC, Kindy MS, Bhat NR, Greig NH, Lahiri DK, Mintzer JE (2004) Cholesterol and Alzheimer’s disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors. Curr Drug Targets 5(6):517–528

    Article  CAS  PubMed  Google Scholar 

  • Sarazin M, Berr C, De Rotrou J, Fabrigoule C, Pasquier F, Legrain S, Michel B, Puel M, Volteau M, Touchon J, Verny M, Dubois B (2007) Amnestic syndrome of the medial temporal type identifies prodromal AD: a longitudinal study. Neurology 69(19):1859–1867

    Article  CAS  PubMed  Google Scholar 

  • Schrag A, Ben-Shlomo Y, Quinn NP (1999) Prevalence of progressive supranuclear palsy and multiple system atrophy: a cross-sectional study. Lancet 354(9192):1771–1775

    Article  CAS  PubMed  Google Scholar 

  • Selkoe DJ, Hardy J (2016) The amyloid hypothesis of Alzheimer’s disease at 25 years. EMBO Mol Med 8(6):595–608

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Stewart R, Masaki K, Xue QL, Peila R, Petrovitch H, White LR, Launer LJ (2005) A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study. Arch Neurol 62(1):55–60

    Article  PubMed  Google Scholar 

  • Tzourio C, Dufouil C, Ducimetiere P, Alperovitch A (1999) Cognitive decline in individuals with high blood pressure: a longitudinal study in the elderly. EVA Study Group. Epidemiology of Vascular Aging. Neurology 53(9):1948–1952

    Article  CAS  PubMed  Google Scholar 

  • Waldemar G, Burns A (2016) Managing behavioral and psychological symptoms in ALzheimer’s disease. O. U. Press, Oxford, pp 71–84

    Google Scholar 

  • Walker Z, Possin KL, Boeve BF, Aarsland D (2015) Lewy body dementias. Lancet 386(10004):1683–1697

    Article  PubMed  Google Scholar 

  • Wang L, Larson EB, Bowen JD, van Belle G (2006) Performance-based physical function and future dementia in older people. Arch Intern Med 166(10):1115–1120

    Article  PubMed  Google Scholar 

  • Weuve J, Kang JH, Manson JE, Breteler MM, Ware JH, Grodstein F (2004) Physical activity, including walking, and cognitive function in older women. JAMA 292(12):1454–1461

    Article  CAS  PubMed  Google Scholar 

  • Whitmer RA, Gunderson EP, Barrett-Connor E, Quesenberry CP Jr, Yaffe K (2005) Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study. BMJ 330(7504):1360

    Article  PubMed  PubMed Central  Google Scholar 

  • Williams DR, de Silva R, Paviour DC, Pittman A, Watt HC, Kilford L, Holton JL, Revesz T, Lees AJ (2005) Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson’s syndrome and PSP-parkinsonism. Brain 128(Pt 6):1247–1258

    Article  PubMed  Google Scholar 

  • Williams DR, Holton JL, Strand K, Revesz T, Lees AJ (2007) Pure akinesia with gait freezing: a third clinical phenotype of progressive supranuclear palsy. Mov Disord 22(15):2235–2241

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Centre Memoire de Ressources et de Recherche, CoBTek “Cognition Behaviour Technology” Research Team, Institut Claude Pompidou, Nice University Hospital, Nice, France

    David Bensamoun, Aurélie Mouton, Eric Ettore, Philippe Robert & Renaud David

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  1. David Bensamoun
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  2. Aurélie Mouton
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  3. Eric Ettore
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  4. Philippe Robert
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  5. Renaud David
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Correspondence to David Bensamoun .

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  1. The Chinese University of Hong Kong, Tai Po, Hong Kong

    Helen Chiu

  2. Sunnybrook Research Institute, Toronto, Ontario, Canada

    Kenneth Shulman

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Bensamoun, D., Mouton, A., Ettore, E., Robert, P., David, R. (2017). (Neurobiology of) Dementia: Causes, Presentation, and Management. In: Chiu, H., Shulman, K. (eds) Mental Health and Illness of the Elderly. Mental Health and Illness Worldwide. Springer, Singapore. https://doi.org/10.1007/978-981-10-2414-6_7

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