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Regulation of Metabolism Across Different Subsets of T Cells in Cancer

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Immune Metabolism in Health and Tumor

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1011))

Abstract

T cells play a critical role to defend against tumor and maintain immune homeostasis. The diverse functions of T cells require precise regulation of metabolic pathways. Recent studies reveal that metabolic changes are tightly linked to the activation and function of T cells. Given the importance of these cells in tumor progression, it is important to understand how the tumor microenvironment regulates metabolism of T cells and how the metabolic reprogramming of T cells affects tumor growth. Here, we review new findings and discuss how metabolic reprogramming of different types of T cells affects the immune response in tumors.

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Author information

Authors and Affiliations

  1. Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China

    Xuerui Luo & Fuxiang Zhu

  2. National Cancer Institute, Bethesda, MD, 20892, USA

    Zuojia Chen

  3. Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, China

    Dan Li

  4. Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

    Dan Li

  5. Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University, Shanghai, 200025, China

    Bin Li

  6. School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China

    Bin Li

  7. CAS Center for Excellence in Molecular Cell Science, CAS Key Laboratory of Molecular Virology and Immunology, Unit of Molecular Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, University of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200025, China

    Bin Li

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  1. Xuerui Luo
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  2. Fuxiang Zhu
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  3. Zuojia Chen
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  4. Dan Li
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Correspondence to Bin Li .

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Editors and Affiliations

  1. Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University, Shanghai, China

    Bin Li

  2. School of Medicine, Shanghai Jiao Tong University, Shanghai, China

    Fan Pan

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Luo, X., Zhu, F., Chen, Z., Li, D., Li, B. (2017). Regulation of Metabolism Across Different Subsets of T Cells in Cancer. In: Li, B., Pan, F. (eds) Immune Metabolism in Health and Tumor. Advances in Experimental Medicine and Biology, vol 1011. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1170-6_6

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