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Hepatoprotective Effects of Xylose-Taurine Reduced Against Hydrogen Peroxide-Induced Oxidative Stress in Cultured Hepatocytes

  • Conference paper
Taurine 10

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 975))

Abstract

In this study, Xylose-Taurine reduced (X-T-R) was synthesized to enhance biological activities. Hence, we investigated the hepatoprotective effects of X-T-R against H2O2-induced hepatocyte damage and apoptosis. The results showed that X-T-R led to the cytoprotective effect against H2O2-induced oxidative stress in cultured hepatocytes such as the improvement of cell viability and the reduction of reactive oxygen species (ROS) production. Additionally, pre-treatment with X-T-R increased the expression of nuclear factor erythroid 2-related factor 2 (Nrf2), NAD(P)H dehydrogenase:quinone 1 (NQO1) and heme oxygenase 1 (HO-1) in cultured hepatocytes. Furthermore, X-T-R protected the cells against apoptosis via regulating the expression level of Bcl-2/Bax as well as the activation of caspase-3. According to the results obtained, X-T-R may be a bio-material for the therapy of hepatic diseases.

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Abbreviations

HO-1:

Heme oxygenase 1

NQO1:

NAD(P)H dehydrogenase:quinone

Nrf2:

Nuclear factor erythroid 2-related factor 2

X-T-R:

Xylose-Taurine reduced

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Author information

Author notes

  1. §S.Y. Park and C.B. Ahn are contributed equally to this study.

    *S.H. Cheong and G. Ahn are contributed equally to this study.

Authors and Affiliations

  1. Department of Food Technology and Nutrition, Chonnam National University, Yeosu, South Korea

    Soo Yeon Park, Chang-Bum Ahn, Ju Hyung Um, Eui Jeong Han, Sun Hee Cheong & Ginnae Ahn

  2. Division of Food and Nutrition, Chonnam National University, Gwang ju, South Korea

    Chang-Bum Ahn

  3. Department of Food and Nutrition, Inha University, Incheon, South Korea

    Kyung Ja Chang

  4. Department of Chemistry, Konkuk University, Seoul, South Korea

    Sung Hoon Kim

  5. Department of Marine Life Science, Jeju National University, Jeju, South Korea

    WonWoo Lee & You-Jin Jeon

  6. Department of Marine Bio-Food Sciences, Chonnam National University, Yeosu, South Korea

    Sun Hee Cheong & Ginnae Ahn

Authors
  1. Soo Yeon Park
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  2. Chang-Bum Ahn
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  3. Kyung Ja Chang
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  4. Sung Hoon Kim
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  5. WonWoo Lee
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  6. Ju Hyung Um
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  7. Eui Jeong Han
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  8. You-Jin Jeon
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  9. Sun Hee Cheong
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  10. Ginnae Ahn
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Corresponding authors

Correspondence to Sun Hee Cheong or Ginnae Ahn .

Editor information

Editors and Affiliations

  1. Department of Life Sciences, University of Seoul, Seoul, South Korea

    Dong-Hee Lee  & Ha Won Kim  & 

  2. College of Medicine, University of South Alabama, Mobile, Alabama, USA

    Stephen W. Schaffer

  3. Department of Developmental Neurobiology, NY State Institute for Basic Research in Developmental Disabilities, New York, USA

    Eunkyue Park

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Park, S.Y. et al. (2017). Hepatoprotective Effects of Xylose-Taurine Reduced Against Hydrogen Peroxide-Induced Oxidative Stress in Cultured Hepatocytes. In: Lee, DH., Schaffer, S.W., Park, E., Kim, H.W. (eds) Taurine 10. Advances in Experimental Medicine and Biology, vol 975. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1079-2_48

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