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Aquaporins in Digestive System

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Book cover Aquaporins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 969))

Abstract

In this chapter, we mainly discuss the expression and function of aquaporins (AQPs ) expressed in digestive system . AQPs in gastrointestinal tract include four members of aquaporin subfamily: AQP1, AQP4, AQP5 and AQP8, and a member of aquaglyceroporin subfamily: AQP3. In the digestive glands, especially the liver, we discuss three members of aquaporin subfamily: AQP1, AQP5 and AQP8, a member of aquaglyceroporin subfamily: AQP9. AQP3 is involved in the diarrhea and inflammatory bowel disease; AQP5 is relevant to gastric carcinoma cell proliferation and migration; AQP9 plays considerable role in glycerol metabolism , urea transport and hepatocellular carcinoma. Further investigation is necessary for specific locations and functions of AQPs in digestive system.

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References

  1. Laforenza U (2012) Water channel proteins in the gastrointestinal tract. Mol Asp Med 33:642–650

    Article  CAS  Google Scholar 

  2. Matsuzaki T, Tajika Y, Ablimit A, Aoki T, Hagiwara H, Takata K (2004) Aquaporins in the digestive system. Med Electron Microsc 37:71–80

    Article  CAS  PubMed  Google Scholar 

  3. Masyuk AI, Marinelli RA, LaRusso NF (2002) Water transport by epithelia of the digestive tract. Gastroenterology 122:545–562

    Article  PubMed  Google Scholar 

  4. Ma T, Verkman A (1999) Aquaporin water channels in gastrointestinal physiology. J Physiol 517:317–326

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Jiang L, Li J, Liu X, Burnstock G, Xiang Z (2014) Expression of aquaporin-4 water channels in the digestive tract of the guinea pig. J Mol Histol 45:229–241

    Article  CAS  PubMed  Google Scholar 

  6. Chang EB, Leung PS (2014) Intestinal water and electrolyte transport in the gastrointestinal system. Springer, Dordrecht, pp 107–134

    Google Scholar 

  7. Wang KS, Komar AR, Ma T, Filiz F, McLeroy J, Hoda K, Verkman A, Bastidas JA (2000) Gastric acid secretion in aquaporin-4 knockout mice. Am J Physiol Gastrointest Liver Physiol 279:G448–G453

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Wang KS, Ma T, Filiz F, Verkman A, Bastidas JA (2000) Colon water transport in transgenic mice lacking aquaporin-4 water channels. Am J Physiol Gastrointest Liver Physiol 279:G463–G470

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Benga G (2012) The first discovered water channel protein, later called aquaporin 1: molecular characteristics, functions and medical implications. Mol Asp Med 33:518–534

    Article  CAS  Google Scholar 

  10. Mobasheri A, Marples D (2004) Expression of the AQP-1 water channel in normal human tissues: a semiquantitative study using tissue microarray technology. Am J Phys Cell Phys 286:C529–C537

    Article  CAS  Google Scholar 

  11. Nielsen S, Smith BL, Christensen EI, Agre P (1993) Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia. Proc Natl Acad Sci 90:7275–7279

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Ma T, Jayaraman S, Wang KS, Song Y, Yang B, Li J, Bastidas JA, Verkman A (2001) Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels. Am J Phys Cell Phys 280:C126–C134

    CAS  Google Scholar 

  13. De Luca A, Vassalotti G, Pelagalli A, Pero M, Squillacioti C, Mirabella N, Lombardi P, Avallone L (2015) Expression and localization of Aquaporin-1 along the intestine of colostrum suckling buffalo calves. Anat Histol Embryol 44:391–400

    Article  CAS  PubMed  Google Scholar 

  14. Talbot NC, Garrett WM, Caperna TJ (2003) Analysis of the expression of aquaporin-1 and aquaporin-9 in pig liver tissue: comparison with rat liver tissue. Cells Tissues Organs 174:117–128

    Article  CAS  PubMed  Google Scholar 

  15. Casotti G, Waldron T, Misquith G, Powers D, Slusher L (2007) Expression and localization of an aquaporin-1 homologue in the avian kidney and lower intestinal tract. Comp Biochem Physiol A Mol Integr Physiol 147:355–362

    Article  CAS  PubMed  Google Scholar 

  16. Parvin MN, Kurabuchi S, Murdiastuti K, Yao C, Kosugi-Tanaka C, Akamatsu T, Kanamori N, Hosoi K (2005) Subcellular redistribution of AQP5 by vasoactive intestinal polypeptide in the Brunner’s gland of the rat duodenum. Am J Physiol Gastrointest Liver Physiol 288:G1283–G1291

    Article  CAS  PubMed  Google Scholar 

  17. Huang Y-H, Zhou X-Y, Wang H-M, Xu H, Chen J, Lv N-H (2013) Aquaporin 5 promotes the proliferation and migration of human gastric carcinoma cells. Tumor Biol 34:1743–1751

    Article  CAS  Google Scholar 

  18. Fischer H, Stenling R, Rubio C, Lindblom A (2001) Differential expression of aquaporin 8 in human colonic epithelial cells and colorectal tumors. BMC Physiol 1:1

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Yang B, Song Y, Zhao D, Verkman AS (2005) Phenotype analysis of aquaporin-8 null mice. Am J Phys Cell Phys 288:C1161–C1170

    Article  CAS  Google Scholar 

  20. Zhao G, Li J, Wang J, Shen X, Sun J (2014) Aquaporin 3 and 8 are down-regulated in TNBS-induced rat colitis. Biochem Biophys Res Commun 443:161–166

    Article  CAS  PubMed  Google Scholar 

  21. Zhao G, Dong P, Peng R, Li J, Zhang D, Wang J, Shen X, Dong L, Sun J (2016) Expression, localization and possible functions of aquaporins 3 and 8 in rat digestive system. Biotech Histochem 91:269–276

    Article  CAS  PubMed  Google Scholar 

  22. Silberstein C, Kierbel A, Amodeo G, Zotta E, Bigi F, Berkowski D, Ibarra C (1999) Functional characterization and localization of AQP3 in the human colon. Braz J Med Biol Res 32:1303–1313

    Article  CAS  PubMed  Google Scholar 

  23. Koyama Y, Yamamoto T, Tani T, Nihei K, Kondo D, Funaki H, Yaoita E, Kawasaki K, Sato N, Hatakeyama K (1999) Expression and localization of aquaporins in rat gastrointestinal tract. Am J Phys Cell Phys 276:C621–C627

    CAS  Google Scholar 

  24. Ikarashi N, Kon R, Sugiyama K (2016) Aquaporins in the colon as a new therapeutic target in Diarrhea and constipation. Int J Mol Sci 17:1172

    Article  PubMed Central  Google Scholar 

  25. Ikarashi N, Kon R, Iizasa T, Suzuki N, Hiruma R, Suenaga K, Toda T, Ishii M, Hoshino M, Ochiai W (2012) Inhibition of aquaporin-3 water channel in the colon induces diarrhea. Biol Pharm Bull 35:957–962

    Article  CAS  PubMed  Google Scholar 

  26. Ikarashi N (2012) The elucidation of the function and the expression control mechanism of aquaporin-3 in the colon. Yakugaku Zasshi J Pharm Soc Jpn 133:955–961

    Article  Google Scholar 

  27. Zhang W, Xu Y, Chen Z, Xu Z, Xu H (2011) Knockdown of aquaporin 3 is involved in intestinal barrier integrity impairment. FEBS Lett 585:3113–3119

    Article  CAS  PubMed  Google Scholar 

  28. Ishibashi K (2009) New members of mammalian aquaporins: AQP10–AQP12. In: Aquaporins. Springer, Berlin, pp 251–262

    Google Scholar 

  29. Wu X, Ren C, Zhou H, Zhang L, Juan C, Yang Y (2014) Therapeutic effect of Zeng Ye decoction on primary Sjögren’s syndrome via upregulation of aquaporin-1 and aquaporin-5 expression levels. Mol Med Rep 10:429–434

    CAS  PubMed  Google Scholar 

  30. Beroukas D, Hiscock J, Jonsson R, Waterman SA, Gordon TP (2001) Subcellular distribution of aquaporin 5 in salivary glands in primary Sjögren’s syndrome. Lancet 358:1875–1876

    Article  CAS  PubMed  Google Scholar 

  31. Delporte C(2009) Aquaporins in secretory glands and their role in Sjögren’s syndrome. In: Aquaporins. Springer, Berlin, pp 185–201

    Google Scholar 

  32. Delporte C, Steinfeld S (2006) Distribution and roles of aquaporins in salivary glands. Biochim Biophys Acta Biomembr 1758:1061–1070

    Article  CAS  Google Scholar 

  33. Laforenza U, Gastaldi G, Grazioli M, Cova E, Tritto S, Faelli A, Calamita G, Ventura U (2005) Expression and immunolocalization of aquaporin-7 in rat gastrointestinal tract. Biol Cell 97:605–613

    Article  CAS  PubMed  Google Scholar 

  34. Okada S, Misaka T, Matsumoto I, Watanabe H, Abe K (2003) Aquaporin-9 is expressed in a mucus-secreting goblet cell subset in the small intestine. FEBS Lett 540:157–162

    Article  CAS  PubMed  Google Scholar 

  35. Maeda N (2012) Implications of aquaglyceroporins 7 and 9 in glycerol metabolism and metabolic syndrome. Mol Asp Med 33:665–675

    Article  CAS  Google Scholar 

  36. Portincasa P, Palasciano G, Svelto M, Calamita G (2008) Aquaporins in the hepatobiliary tract. Which, where and what they do in health and disease. Eur J Clin Investig 38:1–10

    Article  CAS  Google Scholar 

  37. Laforenza U, Bottino C, Gastaldi G (2016) Mammalian aquaglyceroporin function in metabolism. Biochim Biophys Acta Biomembr 1858:1–11

    Article  CAS  Google Scholar 

  38. Lebeck J (2014) Metabolic impact of the glycerol channels AQP7 and AQP9 in adipose tissue and liver. J Mol Endocrinol 52:R165–R178

    Article  CAS  PubMed  Google Scholar 

  39. Maeda N, Funahashi T, Shimomura I (2008) Metabolic impact of adipose and hepatic glycerol channels aquaporin 7 and aquaporin 9. Nat Clin Pract Endocrinol Metab 4:627–634

    CAS  PubMed  Google Scholar 

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Acknowledgments

This work was supported by the grants from National Natural Science Foundation of China (81330074 to Yang, 81261160507 to Yang) and the Programme of Introducing Talents of Discipline to Universities.

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Authors and Affiliations

  1. Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China

    Shuai Zhu Bachelor & Baoxue Yang M.D., Ph.D.

  2. Department of Anatomy and Neuroscience Center, Chongqing Medical University, Chongqing, 400016, China

    Jianhua Ran M.D., Ph.D.

  3. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China

    Baoxue Yang M.D., Ph.D.

  4. Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University, Beijing, 100191, China

    Baoxue Yang M.D., Ph.D.

  5. The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China

    Zhechuan Mei M.D.

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  1. Shuai Zhu Bachelor
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  2. Jianhua Ran M.D., Ph.D.
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  3. Baoxue Yang M.D., Ph.D.
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  4. Zhechuan Mei M.D.
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Correspondence to Zhechuan Mei M.D. .

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Editors and Affiliations

  1. Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China

    Baoxue Yang

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Zhu, S., Ran, J., Yang, B., Mei, Z. (2017). Aquaporins in Digestive System. In: Yang, B. (eds) Aquaporins. Advances in Experimental Medicine and Biology, vol 969. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1057-0_8

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