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Sirtuins pp 213–227Cite as

Sirtuins and Aging

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Part of the book series: Proteins and Cell Regulation ((PROR,volume 10))

Abstract

The advancement of age is accompanied by the increased incidence of various diseases, including neurodegeneration, cancer, and metabolic diseases. At a molecular level, these diseases are associated with a plethora of pathophysiological mechanisms, including deficiency in nutrient sensing, proteostasis, and mitochondrial function. Sirtuins have been implicated in the age-related malfunctioning of these pathways and are thought to be involved in the beneficial effects of caloric restriction. In this chapter, we discuss the current state-of-knowledge regarding the role of sirtuins in aging.

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Authors and Affiliations

  1. Nestlé Institute of Health Sciences, EPFL campus, Quartier de l’Innovation, Bâtiment G, CH-1015, Lausanne, Switzerland

    Carles Cantó

  2. Laboratory Genetic Metabolic Diseases, Academic Medical Center, Amsterdam, The Netherlands

    Riekelt H. Houtkooper

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  1. Carles Cantó
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  2. Riekelt H. Houtkooper
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Correspondence to Carles Cantó or Riekelt H. Houtkooper .

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Editors and Affiliations

  1. Laboratory Genetic Metabolic Diseases, Academic Medical Center, Amsterdam, The Netherlands

    Riekelt H. Houtkooper

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Cantó, C., Houtkooper, R.H. (2016). Sirtuins and Aging. In: Houtkooper, R. (eds) Sirtuins. Proteins and Cell Regulation, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-0962-8_10

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