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Characteristics and Functions of HEV Proteins

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Hepatitis E Virus

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 948))

Abstract

Hepatitis E virus (HEV) is a non-enveloped virus containing a single-stranded, positive-sense RNA genome of 7.2 kb, which consists of a 5ʹ noncoding region, three open reading frames (ORFs), and a 3ʹ noncoding region. ORF1 is diverse between genotypes and encodes the nonstructural proteins, which include the enzymes needed for virus replication. In addition to its role in virus replication, the function of ORF1 is relevant to viral adaption in cultured cells and may also relate to virus infection and HEV pathogenicity. ORF2 protein is the capsid protein, which is about 660 amino acids in length. It not only protects the integrity of the viral genome but is also involved in many important physiological activities, such as virus assembly, infection, and host interaction. The main immune epitopes, especially neutralizing epitopes, are located on ORF2 protein, which is a candidate antigen for vaccine development. ORF3 protein is a phosphoprotein of 113 or 114 amino acids with a molecular weight of 13 kDa with multiple functions that can also induce strong immune reactivity.

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Abbreviations

ASGR:

Asialoglycoprotein receptor

CDK:

Cyclin-dependent kinase

EGFR:

Epidermal growth factor receptor

ER:

Endoplasmic reticulum

ERK:

Extracellularly regulated kinase

GST:

Glutathione s-transferase

Hel:

RNA helicase

HVR:

Proline-rich hypervariable region

MAPK:

Mitogen-activated protein kinases

MeT:

Methyltransferase

ORF:

Open reading frame

PCP:

Papain-like cysteine protease

PLG:

Plasminogen

RdRp:

RNA-dependent RNA polymerase

STAT:

Signal transducer and activator of transcription

VDAC:

Voltage-dependent anion channel

VLP:

Virus-like particle

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Authors and Affiliations

  1. Division of Drug and Cosmetics Inspection, Center for Food and Drug Inspection, China Food and Drug Administration, No.11 Fa Hua Nan Li, Dongcheng District, Beijing, 100061, China

    Yan Zhou M.Sc

  2. Division of HIV/AIDS and Sex-transmitted Virus Vaccines, National Institutes for Food and Drug Control, No. 2 Tiantanxili, Dongcheng District, Beijing, 100050, China

    Chenyan Zhao Ph.D., Nan Xu Ph.D. & Youchun Wang M.D., Ph.D.

  3. Division of Diagnosis, National Institutes for Food and Drug Control, No. 2 Tiantanxili, Dongcheng District, Beijing, 100050, China

    Yabin Tian M.Sc

Authors
  1. Yan Zhou M.Sc
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  2. Chenyan Zhao Ph.D.
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  3. Yabin Tian M.Sc
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  4. Nan Xu Ph.D.
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  5. Youchun Wang M.D., Ph.D.
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Correspondence to Youchun Wang M.D., Ph.D. .

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  1. Division of HIV/AIDS and Sex-transmitted Virus Vaccines, National Institutes for Food and Drug Control, Beijing, China

    Youchun Wang

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Zhou, Y., Zhao, C., Tian, Y., Xu, N., Wang, Y. (2016). Characteristics and Functions of HEV Proteins. In: Wang, Y. (eds) Hepatitis E Virus. Advances in Experimental Medicine and Biology, vol 948. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-0942-0_2

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