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Recent Advances in Redox Active Plant and Microbial Products pp 345–359Cite as

Phytol: A Chlorophyll Component with Anti-inflammatory and Metabolic Properties

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Abstract

The naturally occurring dipterpene molecule Phytol is an alcohol that can be extracted from the chlorophyll of green plants. Phytol has been studied for decades and has been suggested to have both metabolic properties as well as potent anti-inflammatory effects. Phytol represents a molecule derived by nature with lipid regulating properties, in line with today’s need for new drugs to control for diseases that follow the westernized diet and life style. The beneficial effects of phytol on health is in this chapter presented as one interesting naturally derived component in new natural remedies and functional food products to tackle the rapidly increasing global health problems caused by cardiovascular and chronic inflammatory diseases.

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References

  • Allen NE, Grace PB, Ginn A, Travis RC, Roddam AW, Appleby PN, Key T (2008) Phytanic acid: measurement of plasma concentrations by gas–liquid chromatography–mass spectrometry analysis and associations with diet and other plasma fatty acids. Brit J Nutr 99(3):653–659

    Article  CAS  PubMed  Google Scholar 

  • Baxter JH (1968) Absorption of chlorophyll phytol in normal man and in patients with refsum’s disease. J Lipid Res 9(5):636–641

    CAS  PubMed  Google Scholar 

  • Baxter JH, Steinber D (1967) Absorption of phytol from dietary chlorophyll in rat. J Lipid Res 8(6):615–620

    CAS  PubMed  Google Scholar 

  • Baxter JH, Steinberg D, Mize CE, Avigan J (1967) Absorption and metabolism of uniformly 14C-labeled phytol and phytanic acid by the intestine of the rat studied with thoracic duct cannulation. Biochim Biophys Acta 137(2):277–290

    Article  CAS  PubMed  Google Scholar 

  • Chowdhury RR, Ghosh SK (2012) Phytol-derived novel isoprenoid immunostimulants. Front Immunol 3:49

    Article  PubMed Central  PubMed  Google Scholar 

  • Costa JP, Ferreira PB, De Sousa DP, Jordan J, Freitas RM (2012) Anticonvulsant effect of phytol in a pilocarpine model in mice. Neurosci Lett 523(2):115–118

    Article  CAS  PubMed  Google Scholar 

  • Daudin JB, Monnet D, Kavian N, Espy C, Wang A, Chereau C, Goulvestre C, Omri S, Brezin A, Weill B, Batteux F, Nicco C (2011) Protective effect of pristane on experimental autoimmune uveitis. Immunol Lett 141(1):83–93

    Article  CAS  PubMed  Google Scholar 

  • Ellinghaus P, Wolfrum C, Assmann G, Spener F, Seedorf U (1999) Phytanic acid activates the peroxisome proliferator-activated receptor alpha (PPAR alpha) in sterol carrier protein 2-/ sterol carrier protein x-deficient mice. J Biol Chem 274(5):2766–2772

    Article  CAS  PubMed  Google Scholar 

  • Gelderman KA, Hultqvist M, Olsson LM, Bauer K, Pizzolla A, Olofsson P, Holmdahl R (2007) Rheumatoid arthritis: the role of reactive oxygen species in disease development and therapeutic strategies. Antioxid Redox Signal 9(10):1541–1567

    Article  CAS  PubMed  Google Scholar 

  • Gloerich J, van den Brink DM, Ruiter JPN, van Vlies N, Vaz FM, Wanders RJA, Ferdinandusse S (2007) Metabolism of phytol to phytanic acid in the mouse, and the role of PPAR alpha in its regulation. J Lipid Res 48(1):77–85

    Article  CAS  PubMed  Google Scholar 

  • Gloerich J, van Vlies N, Jansen GA, Denis S, Ruiter JPN, van Werkhoven MA, Duran M, Vaz FM, Wanders RJA, Ferdinandusse S (2005) A phytol-enriched diet induces changes in fatty acid metabolism in mice both via PPAR alpha-dependent and -independent pathways. J Lipid Res 46(4):716–726

    Article  CAS  PubMed  Google Scholar 

  • Goto T, Takahashi N, Kato S, Egawa K, Ebisu S, Moriyama T, Fushiki T, Kawada T (2005) Phytol directly activates peroxisome proliferator-activated receptor alpha (PPAR alpha) and regulates gene expression involved in lipid metabolism in PPAR alpha-expressing HepG2 hepatocytes. Biochem biophys res commun 337(2):440–445

    Article  CAS  PubMed  Google Scholar 

  • Gremese E, Ferraccioli G (2011) The metabolic syndrome: the crossroads between rheumatoid arthritis and cardiovascular risk. Autoimmun Rev 10(10):582–589

    Article  CAS  PubMed  Google Scholar 

  • Hashimoto T, Shimizu N, Kimura T, Takahashi Y, Ide T (2006) Polyunsaturated fats attenuate the dietary phytol-induced increase in hepatic fatty acid oxidation in mice. J Nutr 136(4):882–886

    CAS  PubMed  Google Scholar 

  • Heidenreich PA, Trogdon JG, Khavjou OA, Butler J, Dracup K, Ezekowitz MD, Finkelstein EA, Hong YL, Johnston SC, Khera A, Lloyd-Jones DM, Nelson SA, Nichol G, Orenstein D, Wilson PWF, Woo YJ, Coordina AHAA, Council S, Inter CCR, Cardiology CC, Prevention CE, Thrombosi CA, C CCC, Nursing CC, Dis CKC, Anesthe CCS, Quality IC (2011) Forecasting the future of cardiovascular disease in the United States a policy statement from the american heart association. Circulation 123(8):933–944

    Google Scholar 

  • Heim M, Johnson J, Boess F, Bendik I, Weber P, Hunziker W, Fluhmann B (2002) Phytanic acid, a natural peroxisome proliferator-activated receptor agonist, regulates glucose metabolism in rat primary hepatocytes. Faseb J 16(3):718–720

    CAS  PubMed  Google Scholar 

  • Hellgren LI (2010) Phytanic acid-an overlooked bioactive fatty acid in dairy fat? Ann Ny Acad Sci 1190:42–49

    Article  CAS  PubMed  Google Scholar 

  • Hidiroglou M, Jenkins KJ (1972) Effect of phytol on the incidence of muscular dystrophy in rabbits. Can J Physiol Pharmacol 50(2):171–172

    Article  CAS  PubMed  Google Scholar 

  • Holmberg J, Tuncel J, Yamada H, Lu S, Olofsson P, Holmdahl R (2006) Pristane, a non-antigenic adjuvant, induces MHC class II-restricted, arthritogenic T cells in the rat. J Immunol 176(2):1172–1179

    Article  CAS  PubMed  Google Scholar 

  • Hultqvist M, Olofsson P, Gelderman KA, Holmberg J, Holmdahl R (2006) A new arthritis therapy with oxidative burst inducers. PLoS Med 3(9):e348

    Article  PubMed Central  PubMed  Google Scholar 

  • Kahlke W, Wagener H (1966) Conversion of H3-Phytol to phytanic acid and its incorporation into plasma lipid fractions in heredopathia atactica polyneuritiformis. Metab 15(8):687–693

    Article  CAS  Google Scholar 

  • Kitareewan S, Burka LT, Tomer KB, Parker CE, Deterding LJ, Stevens RD, Forman BM, Mais DE, Heyman RA, McMorris T, Weinberger C (1996) Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR. Mol Biol Cell 7(8):1153–1166

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Koch-Henriksen N, Sorensen PS (2010) The changing demographic pattern of multiple sclerosis epidemiology. Lancet Neurol 9(5):520–532

    Article  PubMed  Google Scholar 

  • Lardizabal JA, Deedwania P (2011) Lipid-lowering therapy with statins for the primary and secondary prevention of cardiovascular disease. Cardiol Clin 29(1):87–103

    Article  PubMed  Google Scholar 

  • Lemotte PK, Keidel S, Apfel CM (1996) Phytanic acid is a retinoid X receptor ligand. Eur J Biochem 236(1):328–333

    Article  CAS  PubMed  Google Scholar 

  • Lim SY, Bauermeister A, Kjonaas RA, Ghosh SK (2006a) Phytol-based novel adjuvants in vaccine formulation: 2. assessment of efficacy in the induction of protective immune responses to lethal bacterial infections in mice. J Immune Based Ther Vaccines 4:5

    Article  PubMed Central  PubMed  Google Scholar 

  • Lim SY, Meyer M, Kjonaas RA, Ghosh SK (2006b) Phytol-based novel adjuvants in vaccine formulation: 1. assessment of safety and efficacy during stimulation of humoral and cell-mediated immune responses. J Immune Based Ther Vaccines 4:6

    Article  PubMed Central  PubMed  Google Scholar 

  • Lin Y, Mousa SS, Elshourbagy N, Mousa SA (2010) Current status and future directions in lipid management: emphasizing low-density lipoproteins, high-density lipoproteins, and triglycerides as targets for therapy. Vasc Vascular health Risk Manage 6:73–85

    CAS  Google Scholar 

  • Masters-Thomas A, Bailes J, Billimoria JD, Clemens ME, Gibberd FB, Page NG (1980) Heredopathia atactica polyneuritiformis (Refsum’s disease): 1. Clinical features and dietary management. J Hum Nutr 34(4):245–250

    CAS  PubMed  Google Scholar 

  • McCarty MF (2001) The chlorophyll metabolite phytanic acid is a natural rexinoid—potential for treatment and prevention of diabetes. Med Hypotheses 56(2):217–219

    Article  CAS  PubMed  Google Scholar 

  • McKeage K, Keating GM (2011) Fenofibrate a review of its use in dyslipidaemia. Drugs 71(14):1917–1946

    Article  CAS  PubMed  Google Scholar 

  • Mize CE, Avigan J, Baxter JH, Fales HM, Steinberg D (1966) Metabolism of phytol-U-14C and phytanic acid-U-14C in the rat. J Lipid Res 7(5):692–697

    CAS  PubMed  Google Scholar 

  • Mukherji M, Schofield CJ, Wierzbicki AS, Jansen GA, Wanders RJ, Lloyd MD (2003) The chemical biology of branched-chain lipid metabolism. Prog Lipid Res 42(5):359–376

    Article  CAS  PubMed  Google Scholar 

  • Nedergaard J, Cannon B (2010) The changed metabolic world with human brown adipose tissue: therapeutic visions. Cell Metab 11(4):268–272

    Article  CAS  PubMed  Google Scholar 

  • Nordestgaard BG, Chapman MJ, Ray K, Boren J, Andreotti F, Watts GF, Ginsberg H, Amarenco P, Catapano A, Descamps OS, Fisher E, Kovanen PT, Kuivenhoven JA, Lesnik P, Masana L, Reiner Z, Taskinen MR, Tokgozoglu L, Tybjaerg-Hansen A, Conse EAS (2010) Lipoprotein(a) as a cardiovascular risk factor: current status. Eur Heart J 31(23):2844–2853

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Olofsson P, Holmberg J, Tordsson J, Lu SM, Akerstrom B, Holmdahl R (2003) Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Nat Genet 33(1):25–32

    Article  CAS  PubMed  Google Scholar 

  • Patton S, Benson AA (1966) Phytol metabolism in the bovine. Biochim Biophys Acta 125(1):22–32

    Article  CAS  PubMed  Google Scholar 

  • Pereira RM, de Carvalho JF, Bonfa E (2009) Metabolic syndrome in rheumatological diseases. Autoimmun Rev 8(5):415–419

    Article  CAS  PubMed  Google Scholar 

  • Refsum S (1976) Heredopathia atactica polyneurotiformis: therapeutic and pathogenetic aspects. Rivista di patologia nervosa e mentale 97(3):115–126

    CAS  PubMed  Google Scholar 

  • Schluter A, Barbera MJ, Iglesias R, Giralt M, Villarroya F (2002a) Phytanic acid, a novel activator of uncoupling protein-1 gene transcription and brown adipocyte differentiation. Biochem J 362(Pt 1):61–69

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Schluter A, Giralt M, Iglesias R, Villarroya F (2002b) Phytanic acid, but not pristanic acid, mediates the positive effects of phytol derivatives on brown adipocyte differentiation. FEBS Lett 517(1–3):83–86

    Article  CAS  PubMed  Google Scholar 

  • Scott DL, Wolfe F, Huizinga TWJ (2010) Rheumatoid arthritis. Lancet 376(9746):1094–1108

    Article  PubMed  Google Scholar 

  • Sheng X, Murphy MJ, MacDonald TM, Wei L (2012) Effect of statins on total cholesterol concentrations and cardiovascular outcomes in patients with diabetes mellitus: a population-based cohort study. Eur J Clin Pharmacol 68(8):1201–1208

    Article  CAS  PubMed  Google Scholar 

  • Shimizu M, Tomoo T (1994) Anti-inflammatory constituents of topically applied crude drugs. V. Constituents and anti-inflammatory effect of Aoki, Aucuba japonica Thunb. Biol Pharm Bulletin 17(5):665–667

    Article  CAS  Google Scholar 

  • Steinberg D, Avigan J, Mize CE, Baxter JH, Cammermeyer J, Fales HM, Highet PF (1966) Effects of dietary phytol and phytanic acid in animals. J Lipid Res 7(5):684–691

    CAS  PubMed  Google Scholar 

  • ten Brink HJ, Schor DS, Kok RM, Poll-The BT, Wanders RJ, Jakobs C (1992) Phytanic acid alpha-oxidation: accumulation of 2-hydroxyphytanic acid and absence of 2-oxophytanic acid in plasma from patients with peroxisomal disorders. J Lipid Res 33(10):1449–1457

    PubMed  Google Scholar 

  • Todd JA, Knip M, Mathieu C (2011) Strategies for the prevention of autoimmune type 1 diabetes. Diabet Med: J British Diabet Assoc 28(10):1141–1143

    Article  CAS  Google Scholar 

  • Van den Branden C, Vamecq J, Wybo I, Roels F (1986) Phytol and peroxisome proliferation. Pediatr Res 20(5):411–415

    Article  PubMed  Google Scholar 

  • van den Brink DM, Wanders RJ (2006) Phytanic acid: production from phytol, its breakdown and role in human disease. Cell Mol Life Sci: CMLS 63(15):1752–1765

    Article  PubMed  Google Scholar 

  • Verhoeven NM, Wanders RJ, Poll-The BT, Saudubray JM, Jakobs C (1998) The metabolism of phytanic acid and pristanic acid in man: a review. J Inherit Metab Dis 21(7):697–728

    Article  CAS  PubMed  Google Scholar 

  • Vijgen GH, Bouvy ND, Teule GJ, Brans B, Schrauwen P, van Marken Lichtenbelt WD (2011) Brown adipose tissue in morbidly obese subjects. PLoS One 6(2):e17247

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Werner LB, Hellgren LI, Raff M, Jensen SK, Petersen RA, Drachmann T, Tholstrup T (2011) Effect of dairy fat on plasma phytanic acid in healthy volunteers—a randomized controlled study. Lipids Health Dis 10:95

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Zomer AW, van Der Burg B, Jansen GA, Wanders RJ, Poll-The BT, van Der Saag PT (2000) Pristanic acid and phytanic acid: naturally occurring ligands for the nuclear receptor peroxisome proliferator-activated receptor alpha. J Lipid Res 41(11):1801–1807

    CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Redoxis AB, Medicon Village, 223 81, Lund, Sweden

    Peter Olofsson & Malin Hultqvist

  2. Center for Biological Sequence Analysis, DTU Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark

    Lars I. Hellgren

  3. Medical Inflammation Research, MBB, Karolinska Institutet, Stockholm, Sweden

    Rikard Holmdahl

Authors
  1. Peter Olofsson
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  2. Malin Hultqvist
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  3. Lars I. Hellgren
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  4. Rikard Holmdahl
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Corresponding author

Correspondence to Peter Olofsson .

Editor information

Editors and Affiliations

  1. Bioorganic Chemistry/School of Pharmacy, University of Saarland, Saarbrücken, Saarland, Germany

    Claus Jacob

  2. SRSMC UMR 7565, Université de Lorraine, Metz, Moselle, France

    Gilbert Kirsch

  3. Plant Physiology (Bio III), RWTH Aachen University, Aachen, Germany

    Alan Slusarenko

  4. Medical School, University of Exeter, Exeter, United Kingdom

    Paul G. Winyard

  5. Bioorganic Chemistry/School of Pharmacy, University of Saarland, Saarbrücken, Saarland, Germany

    Torsten Burkholz

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Olofsson, P., Hultqvist, M., Hellgren, L.I., Holmdahl, R. (2014). Phytol: A Chlorophyll Component with Anti-inflammatory and Metabolic Properties. In: Jacob, C., Kirsch, G., Slusarenko, A., Winyard, P., Burkholz, T. (eds) Recent Advances in Redox Active Plant and Microbial Products. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8953-0_13

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