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The Era of Big Data: From Data-Driven Research to Data-Driven Clinical Care

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Application of Clinical Bioinformatics

Part of the book series: Translational Bioinformatics ((TRBIO,volume 11))

Abstract

When the era of big data arrived in the early nineteen nineties, biomedical research boosted new innovations, procedures and methods aiding in clinical care and patient management. This chapter provides an introduction to the basic concepts and strategies of data-driven biomedical research and application, an area that is explained using terms such as computational biomedicine or clinical/medical bioinformatics. After a brief motivation it starts with a survey on data sources and bioanalytic technologies for high-throughput data generation, a selection of experimental study designs and their applications, procedures and recommendations on how to handle data quality and privacy, followed by a discussion on basic data warehouse concepts utilized for life science data integration, data mining and knowledge discovery. Finally, five application examples are briefly delineated, emphazising the benefit and power of computational methods and tools in this field. The author trusts that this chapter will encourage the reader to handle and interpret the huge amount of data usually generated in research projects or clinical routine to exploit mined bioinformation and medical knowledge for individualized health care.

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Notes

  1. 1.

    It comprises so-called dimension tables containing data from different data sources and fact tables connecting various dimension tables.

  2. 2.

    It uses a transformation of the dimension tables to the third normal form with less data space needed, but more complex data queries.

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Authors and Affiliations

  1. Institute of Health Care Engineering with European Notified Body of Medical Devices, Graz University of Technology, Stremayrgasse 16, A-8010, Graz, Austria

    Christian Baumgartner Ph.D.

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  1. Christian Baumgartner Ph.D.
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Correspondence to Christian Baumgartner Ph.D. .

Editor information

Editors and Affiliations

  1. Shanghai Inst.of Clinical Bioinformatics, Zhongshan Hospital, Fudan University, Shang Hai, China

    Xiangdong Wang

  2. Institute of Health Care Engineering, Graz University of Technology, Graz, Austria

    Christian Baumgartner

  3. School Of Medicine & Medical Science, University College Dublin, Dublin 4, Ireland

    Denis C. Shields

  4. Health and Tropical Medicine, Tulane University School of Public Healt, New Orleans, Louisiana, USA

    Hong-Wen Deng

  5. Section of Clinical Bioinformatics, Swiss Institute of Bioinformatics, Switzerland

    Jacques S Beckmann

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Baumgartner, C. (2016). The Era of Big Data: From Data-Driven Research to Data-Driven Clinical Care. In: Wang, X., Baumgartner, C., Shields, D., Deng, HW., Beckmann, J. (eds) Application of Clinical Bioinformatics. Translational Bioinformatics, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7543-4_1

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