Abstract
Primary amyloidosis [AL] and Light Chain Deposition Disease [LCDD] are characterized by the presence of free, monoclonal immunoglobulin light chains. AL is a lethal, plasma cell dyscrasia. The amyloid fibrils are derived from circulating light chains and deposited in an insoluble fibrillar form in a wide range of organs. The diagnosis of AL is characteristically made by biopsy of rectal mucosa or by subcutaneous fat pad aspiration. Measurement of a monoclonal light chain by immunofixation electrophoresis (IFE) is a useful diagnostic trigger and monitor of the progress and efficacy of therapy in these individuals. In LCDD, the light chain is not modified and is deposited in native form, most commonly in the kidneys.
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© 2003 Springer Science+Business Media Dordrecht
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Bradwell, A.R. et al. (2003). Poster communications. In: Touchard, G., Aucouturier, P., Hermine, O., Ronco, P. (eds) Monoclonal Gammopathies and the Kidney. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0191-4_24
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DOI: https://doi.org/10.1007/978-94-017-0191-4_24
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-6199-7
Online ISBN: 978-94-017-0191-4
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