Skip to main content
SpringerLink
Log in

Intestinal graft-versus-host disease

  • Chapter
Immunology of Gastrointestinal Disease

Part of the book series: Immunology and Medicine Series ((IMME,volume 19))

Abstract

The enteropathy caused by acute graft-versus-host (GVH) disease is an important clinical problem in patients receiving allogeneic bone marrow transplants (BMT), and intestinal damage is also an invariable feature of most animal models of GVH disease. The pattern of pathology in intestinal GVH disease also reproduces a variety of other, naturally occurring enteropathies. Thus, a knowledge of the pathophysiology of intestinal GVH disease is important both for improving the management of BMT patients and for understanding the immunopathogenesis of many other intestinal diseases. This chapter will review the pathogenesis of intestinal GVH disease, placing particular emphasis on the relationship between individual aspects of mucosal pathology and specific immune effector mechanisms.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Billingham, R. E., Brent, L. and Medawar, P. B. (1955). Acquired tolerance of skin homografts. Ann. NY Acad. Sci., 59, 409–98

    Article  PubMed  CAS  Google Scholar 

  2. Billingham, R. E. (1967). The biology of graft-versus-host reactions. Harvey Lectures, 62,21–79

    CAS  Google Scholar 

  3. Spitzer, T. R. (1990). Transfusion induced graft-vs-host disease. In Burakoff, S. J., Deeg, H. J., Ferrara, J. and Atkinson, K. (eds), Graft-vs-Host Disease: Immunology, Pathophysiology and Treatment. New York: Marcel Dekker, pp. 539–50

    Google Scholar 

  4. Pomposelli, F., Maki, T., Kiyoizumi, T., Gaver, L., Balogh, K. and Monaco, A. P. (1985). Induction of graft-versus-host disease by small intestinal allotransplantation in rats. Transplantation, 40, 343–7

    Article  PubMed  CAS  Google Scholar 

  5. Schraut, W. H., Lee, K. K. W., Dawson, J. and Hurst, R. D. (1986). Graft-versus-host disease induced by small bowel allografts. Transplantation, 41, 286–90

    Article  PubMed  CAS  Google Scholar 

  6. Deeg, H. J. and Cottier-Fax, M. (1990). Clinical spectrum and pathophysiology of acute graft-vs-host disease. In Burakoff, S. J., Deeg, H. J., Ferrara, J. and Atkinson, K. (eds), Graft-vs-Host Disease: Immunology, Pathophysiology and Treatment. New York: Marcel Dekker, pp. 311–35

    Google Scholar 

  7. Cox, G. J. and McDonald, G. B. (1990). Graft-versus-host disease of the intestine. Springer Semin. Immunpathol., 12, 283–99

    Google Scholar 

  8. Slavin, R. E. and Santos, G. W. (1973). The graft-versus-host reaction in man after bone marrow transplantation: pathology, pathogenesis, clinical features and implications. Clin. Immunol. Immunopathol., 1, 472–98

    Article  PubMed  CAS  Google Scholar 

  9. Slavin, R. E. and Woodruff, J. M. (1974). The pathology of bone-marrow transplantation. In Sommers, S. C. (ed.), Pathology Annual. New York: Appleton-Century-Crofts, pp. 291–344

    Google Scholar 

  10. Storb, R. and Thomas, E. D. (1983). Allogeneic bone marrow transplantation. Immunol. Rev., 71, 77

    Article  PubMed  CAS  Google Scholar 

  11. Herve, P., Cahn, J.-Y. and Beatty, P. G. (1990). Graft-vs-host disease after bone marrow transplantation from donors other than HLA-identical siblings. In Burakoff, S. J., Deeg, H. J., Ferrara, J. and Atkinson, K. (eds), Graft-vs-Host Disease. Immunology, Pathology and Treatment. New York: Marcel Dekker, pp. 425–54

    Google Scholar 

  12. Mowat, A. Mcl., MacKenzie, S., Baca, M. E., Felstein, M. V. and Parrott, D. M. V. (1987). Functional characteristics of intraepithelial lymphocytes from mouse small intestine. II. In vivo and in vitro responses of intraepithelial lymphocytes to mitogenic and allogeneic stimuli. Immunology, 58, 627–34

    Google Scholar 

  13. Davies, M. D. J. and Parrott, D. M. V. (1981). Cytotoxic T cells in small intestinal epithelial, lamina propria and lung lymphocytes. Immunology, 44, 367–71

    PubMed  CAS  Google Scholar 

  14. Kernan, N. A. (1990). Graft failure following transplantation of T-cell-depleted marrow. In Burakoff, S. J., Deeg, H. J., Ferrara, J. and Atkinson, K. (eds), Graft-versus-Host Disease: Immunology, Pathology and Treatment. New York: Marcel Dekker, pp. 557–68

    Google Scholar 

  15. Dosch, H.-M. and Gelfand, E. W. (1981). Failure of T and B cell cooperation during graft-versus-host disease. Transplant, 31, 48–50

    Article  CAS  Google Scholar 

  16. Korsmeyer, S. I, Elfenbein, G. I, Godlman, C. K., Marshall, S. L., Santos, G. W. and Waldmann, T. A. (1982). B cell, helper T cells and suppressor T cell abnormalities contribute to disordered immunoglobulin synthesis in patients following bone marrow transplantation. Transplant, 33, 184–90

    Article  CAS  Google Scholar 

  17. Ferrara, J. L. M, Daley, J. P., Burakoff, S. J. and Miller, R. A. (1987). Functional T cell deficits after bone marrow transplantation across minor histocompatibility barriers: effects of graft-vs-host disease on precursor frequency of reactive cells. J. Immunol., 138, 3598–603

    PubMed  CAS  Google Scholar 

  18. Moser, M., Sharrow, S. O. and Shearer, G. M. (1988). Role of L3T4+ and Lyt2+ donor cells in graft-versus-host immune deficiency induced across a class I, class II, or whole H-2 difference. J. Immunol., 140, 2600–08

    PubMed  CAS  Google Scholar 

  19. Levy, R. B., Jones, M. and Gray, C. (1990). Isolated peripheral T cells from GvHR recipients exhibit defective IL-2R expression IL-2 production and proliferation in response to activation stimuli. J. Immunol., 145, 3998–4005

    PubMed  CAS  Google Scholar 

  20. Lapp, W. S., Ghayur, T., Mendes, M., Seddik, M. and Seemayer, T. A. (1985). The functional and histological basis for graft-versus-host induced immunosuppression. Immunol Rev., 88, 107–33

    Article  PubMed  CAS  Google Scholar 

  21. Piguet, P. F., Grau, G. E., Collart, M. A., Vassalli, P. and Kapanci, Y. (1989). Pneumopathies of the graft-versus-host reaction: alveolitis associated with an increased level of TNF mRNA and chronic interstitial pneumonitis. Lab. Invest., 61, 37–45

    PubMed  CAS  Google Scholar 

  22. Grundy, J. E., Shanley, J. D. and Shearer, G. M. (1985). Augmentation of graft-versus-host reaction by cytomegalovirus infections resulting in interstitial pneumonitis. Transplantation, 39, 548–53

    Article  PubMed  CAS  Google Scholar 

  23. Beschorner, W. E., Saral, R., Hutchins, G. M., Tutschka, P. J. and Santos, G. W. (1978). Lymphocytic bronchitis associated with graft-vs-host disease in recipients of bone marrow transplants. N. Engl. J. Med., 299, 1030–36

    Article  PubMed  CAS  Google Scholar 

  24. Parfrey, N. A., Ste-Croix, H. and Prudhomme, G. J. (1989). Evidence that nonlymphoid tissue injury in acute graft-versus-host disease is limited to epithelial cells aberrantly expressing MHC antigens. Transplantation, 48, 655–60

    PubMed  CAS  Google Scholar 

  25. Vok-Platzer, B. and Singl, G. (1990). Cutaneous graft-vs-host disease. In Burakoff, S. J., Deeg, H. J., Ferrara, J. and Atkinson, K. (eds), Graft-versus-Host Disease: Immunology, Pathology and Treatment. New York: Marcel Dekker, pp. 245–54

    Google Scholar 

  26. Piguet, P. F., Janin-Mercier, A., Vassalli, P. and Saurat, J. H. (1987). Epidermal lesions of the GvHR: evaluation of the role of different MHC and non MHC loci and of the Lyt-2+ and L3T4+ T lymphocytes. J. Immunol., 139, 406–10

    PubMed  CAS  Google Scholar 

  27. Piguet, P.-F., Grau, G. E., Allet, B. and Vassalli, P. (1987). Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs-host disease. J. Exp. Med., 166, 1280–9

    Article  PubMed  CAS  Google Scholar 

  28. Piguet, P.-F. (1990). Tumor necrosis factor and graft-vs-host disease. In Burakoff, S. J., Deeg, H. J., Ferrara, J. and Atkinson, K. (eds), Graft-vs-Host Disease: Immunology, Pathology and Treatment. New York: Marcel Dekker, pp. 255–76

    Google Scholar 

  29. Snover, D. C, Weisdorf, S. A., Ramsay, N. K. C, McGlave, P. and Kersey, J. H. (1984). Hepatic graft versus host disease: a study of the predictive value of liver biopsy in diagnosis. Hepatology, 4, 123–30

    Article  PubMed  CAS  Google Scholar 

  30. Shulman, H. M., Sharma, P., Amos, D., Fenster, L. F. and McDonald, G. B. (1988). A coded histologic study of hepatic graft-versus-host disease after human bone marrow transplantation. Hepatology, 8, 463–70

    Article  PubMed  CAS  Google Scholar 

  31. McDonald, G. B., Shulman, H. M., Sullivan, K. M. and Spencer, G. D. (1986). Intestinal and hepatic complication of human bone marrow transplantation. Gastroenterology, 90,460

    PubMed  CAS  Google Scholar 

  32. Snover, D. C. (1990). The pathology of acute graft-vs-host disease. In Burakoff, S. J., Deeg, H. J., Ferrara, J. and Atkinson, K. (eds), Graft-versus-host Disease: Immunology, Pathology and Treatment. New York: Marcel Dekker, pp. 337–53

    Google Scholar 

  33. McDonald, G. V. and Sale, G. E. (1984). The gastrointestinal tract after allogeneic bone marrow transplantation in humans. In Sale, G. E. and Shulman, H. M. (eds), The Pathology of Bone Marrow Transplantation. New York: Masson, pp. 77–103

    Google Scholar 

  34. Spencer, G. D., Shulman, H. M., Myerson, D., Thomas, E. D. and McDonald, G. B. (1986). Diffuse intestinal ulceration after marrow transplantation. Human Pathol., 17, 621–33

    Article  CAS  Google Scholar 

  35. Simonsen, M. (1962). Graft versus host reactions. Their natural history and applicability as tools of research. Progr. Allergy, 6, 349–467

    CAS  Google Scholar 

  36. Cornelius, E. A. (1970). Protein-losing enteropathy in the graft-versus-host reaction. Transplant, 9, 247–52

    Article  CAS  Google Scholar 

  37. Hedberg, C. A., Reiser, S. and Reilly, R. W. (1968). Intestinal phase of the ranting syndrome in mice. II. Observations on nutrient absorption and certain disaccharidase abnormalities. Transplantation, 6, 104–10

    Article  PubMed  CAS  Google Scholar 

  38. Lund, E. K., Bruce, M. G., Smith, M. W. and Ferguson, A. (1986). Selective effects of graft-versus-host reaction on disaccharidase expression by mouse jejunal enterocytes. Clin. Sci., 71, 189–98

    PubMed  CAS  Google Scholar 

  39. Weisdorf, S. A., Salati, L. M, Longsdorf, J. A., Ramsay, N. K. C. and Sharp, H. L. (1988). Graft-versus-host disease of the intestine: a protein losing enteropathy characterized by fecal aj-anti-trypsin. Gastroenterology, 85, 1076–81

    Google Scholar 

  40. Piguet, P.-F. (1985). GvHR elicited by products of class I or class II loci of the MHC: analysis of the response of mouse T lymphocytes to products of class I and class II loci of the MHC in correlation with GvHR-induced mortality, medullary aplasia and enteropathy. J. Immunol., 135, 1637–43

    PubMed  CAS  Google Scholar 

  41. Turner, M. W., Boulton, P., Shields, J. G., Strobel, S, Gibson, S., Miller, H. R. P. and Levinsky, R. J. (1988). Intestinal hypersensitivity reactions in the rat. I. Uptake of intact protein, permeability to sugars and their correlation with mucosal mast cell activation. Immunology, 63, 119–24

    PubMed  CAS  Google Scholar 

  42. Walker, R. I. (1978). The contribution of intestinal endotoxin to mortality in hosts with compromised resistance. A review. Exp. Haematol., 6, 172–84

    CAS  Google Scholar 

  43. Cunningham-Rundles, G, Brandeis, W. E., Safai, B, O’Reilly, R., Day, N. K. and Good, R. A. (1979). Selective IgA deficiency and circulating immune complexes containing bovine proteins in a child with chronic graft-versus-host disease. Am. J. Med., 67, 883–90

    Article  PubMed  CAS  Google Scholar 

  44. Strobel, S., Mowat, A. Mcl. and Ferguson, A. (1985). Prevention of oral tolerance induction to ovalbumin and enhanced antigen presentation during a graft-versus-host reaction in mice. Immunology, 56, 57–64

    PubMed  CAS  Google Scholar 

  45. Via, G S., Sharrow, S. O. and Shearer, G. M. (1987). Role of cytotoxic T lymphocytes in the prevention of lupus-like disease occurring in a murine model of graft-versus-host disease. J. Immunol., 139, 1840–9

    PubMed  CAS  Google Scholar 

  46. Sviland, L., Pearson, A. D. J., Eastham, E. J., Hamilton, P. J., Proctor, S. J., Malcolm, A. J. and the Newcastle upon Tyne Bone Marrow Transplant Group (1988). Histological features of skin and rectal biopsy specimens after autologous and allogeneic bone marrow transplantation. J. Clin. Pathol., 41, 148–54

    Article  PubMed  CAS  Google Scholar 

  47. Reilly, R. W. and Kirsner, J. B. (1965). Runt intestinal disease. Lab. Invest., 14, 102–7

    PubMed  CAS  Google Scholar 

  48. Thiele, D. L., Eigenbrodt, M. L., Bryde, S. E., Eigenbrodt, E. H. and Lipsky, P. E. (1989). Intestinal graft-versus-host disease is initiated by donor T cell distinct from classic cytotoxic T lymphocytes. J. Clin. Invest., 84, 1947–56

    Article  PubMed  CAS  Google Scholar 

  49. Gorer, P. A. and Boyse, E. A. (1959). Pathological changes in F1 hybrid mice following transplantation of spleen cells from donors of the parental strains. Immunology, 2, 182–93

    PubMed  CAS  Google Scholar 

  50. Wall, A. J., Rosenberg, J. L. and Reilly, R. W. (1971). Small intestinal injury in the immunologically runted mouse. Morphologic and autoradiographic studies. J. Lab. Clin. Med., 78, 833–4A

    PubMed  CAS  Google Scholar 

  51. van Bekkum, D. W. and Knaan, S. (1977). Role of bacterial microflora in development of intestinal lesions from GvHR. J. Natl. Cancer Inst., 58, 787–90

    PubMed  Google Scholar 

  52. Eigenbrodt, M. L., Eigenbrodt, E. H. and Thiele, D. L. (1991). Histologic similarity of murine colonic graft-versus-host disease (GvHD) to human colonic GvHD and inflammatory bowel disease. Am. J. Pathol. (In press)

    Google Scholar 

  53. MacDonald, T. T. and Ferguson, A. (1977). Hypersensitivity reactions in the small intestine. III. The effects of allograft rejection and of GvHD on epithelial cell kinetics. Cell Tiss. Kinet., 10, 301–12

    CAS  Google Scholar 

  54. Mowat, A. Mcl. and Ferguson, A. (1982). Intraepithelial lymphocyte count and crypt hyperplasia measure the mucosal component of the graft-versus-host reaction in mouse small intestine. Gastroenterology, 83, 417–23

    PubMed  CAS  Google Scholar 

  55. Mowat, A. Mcl., Felstein, M. V., Borland, A. and Parrott, D. M. V. (1988). Experimental studies of immunologically mediated enteropathy. Delayed type hypersensitivity is responsible for the proliferative and destructive enteropathy in irradiated mice with graft-versus-host reaction. Gut, 29, 949–56

    Article  PubMed  CAS  Google Scholar 

  56. Felstein, M. V. and Mowat, A. Mcl. (1988). Experimental studies of immunologically mediated enteropthy. IV. Correlation between immune effector mechanisms and type of enteropathy during a graft-versus-host reaction in neonatal mice of different ages. Clin. Exp. Immunol., 12, 108

    Google Scholar 

  57. Mowat, A. Mcl. and Felstein, M. V. (1990). Experimental studies of immunologically mediated enteropathy. V. Destructive enteropathy during an acute graft-versus-host reaction in adult BDF1 mice. Clin. Exp. Immunol., 19, 279–84

    Article  Google Scholar 

  58. Mowat, A. Mcl. and Ferguson, A. (1981). Hypersensitivity reactions in the small intestine. 6. Pathogenesis of the graft-versus-host reaction in the small intestinal mucosa of the mouse. Transplantation, 32, 238–43

    Article  PubMed  CAS  Google Scholar 

  59. Elson, C. O., Reilly, R. W. and Rosenberg, I. H. (1977). Small intestinal injury in the GvHR: an innocent bystander phenomenon. Gastroenterology, 72, 886–9

    PubMed  CAS  Google Scholar 

  60. Barclay, A. N. and Mason, D. W. (1982). Induction of la antigen in rat epidermal cells and gut epithelium by immunological stimuli. J. Exp. Med., 156, 1665–76

    Article  PubMed  CAS  Google Scholar 

  61. Sviland, L., Pearson, A. D., Eastham, E. J., Green, M. A., Hamilton, P. J., Proctor, S. J. and Malcolm, A. J. (1988). Class II antigen expression by keratinocytes and enterocytes-an early feature of graft-versus-host disease. Transplantation, 46, 402

    Article  PubMed  CAS  Google Scholar 

  62. Nakhleh, R. E., Snover, D. C, Weisdorf, S. and Piatt, J. L. (1989). Immunopathology of graft-versus-host disease in the upper gastrointestinal tract. Transplantation, 48, 61–5

    Article  PubMed  CAS  Google Scholar 

  63. Rappaport, H., Khalil, A., Halle-Pannenko, O., Pritchard, L., Dantchev, D. and Mathe, G. (1979). Histopathologic sequence of events in adult mice undergoing lethal graft-versus-host reaction developed across H-l and/or non-H-2 histocompatibility barriers. Am. J. Pathol., 96, 121–42

    PubMed  CAS  Google Scholar 

  64. Nowell, P. C. and Cole, L. J. (1959). Lymphoid pathology in homologous disease of mice. Transplant. Bull., 6, 435

    Article  PubMed  CAS  Google Scholar 

  65. Simonsen, M. (1962). Graft-versus-host reactions. Their natural history and applicability as tools of research. Progr. Allergy, 6, 349–467

    CAS  Google Scholar 

  66. Gold, J. A., Kosek, J., Wanek, N. and Bauer, S. (1976). Duodenal immunoglobulin deficiency in graft-versus-host disease (GvHD) mice. J. Immunol., 117, 471–476

    PubMed  CAS  Google Scholar 

  67. Guy-Grand, D., Griscelli, C. and Vassalli, P. (1978). The mouse gut T-lymphocyte, a novel type of T-cell: nature, origin and traffic in mice in normal and graft-versus-host conditions. J. Exp. Med., 148, 1661–77

    Article  PubMed  CAS  Google Scholar 

  68. Guy-Grand, D. and Vassalli, P. (1986). Gut injury in mouse graft-versus-host reaction. Study of its occurrence and mechanisms. J. Clin. Invest., 11, 1584–95

    Article  Google Scholar 

  69. Dilly, S. A. and Sloane, J. P. (1987). Changes in rectal leukocytes after allogeneic bone marrow transplantation. Clin. Exp. Immunol., 62, 545

    Google Scholar 

  70. Guy-Grand, D., Cerf-Bensussan, N., Malissen, B., Malassis-Seris, M., Briottet, C. and Vassalli, P.l (1991). Two gut intraepithelial CD8+ lymphocyte populations with different T cell recptors: a role for the gut epithelium in T cell differentiation. J. Exp. Med., 173,471–81

    Article  PubMed  CAS  Google Scholar 

  71. Sprent, J. (1976). Fate of H-2 activated T-lymphocytes in Syngeneic Hosts. I. Fate in lymphoid tissues and intestines traced with 3H-thymidine, 125I-deoxy-uridine and 51chromium. Cell Immunol., 21, 278–302

    Article  PubMed  CAS  Google Scholar 

  72. Ferguson, A., Cummins, A. G., Munro, G. H., Gibson, S. and Miller, H. R. P. (1988). Intestinal mucosal mast cells in rats with graft-versus-host reaction. Adv. Exp. Med. Biol., 216A, 625–34

    Google Scholar 

  73. Cummins, A. G., Munro, G. H., Miller, H. R. P. and Ferguson, A. (1989). Effect of cyclosporin A treatment on the enteropathy of graft-versus-host reaction in the rat: a quantitative study of intestinal morphology, epithelial cell kinetics and mucosal immune activity. Immunol. Cell Biol., 67, 153–60

    Article  PubMed  CAS  Google Scholar 

  74. Crapper, R. M. and Schrader, J. W. (1986). Evidence for the in vivo production and release into the serum of a T cell lymphokine, persisting-cell stimulating factor (PSF), during graft-versus-host reactions. Immunology, 57, 553–8

    PubMed  CAS  Google Scholar 

  75. Newlands, G. J., Mowat, A. Mcl., Felstein, M. V. and Miller, H. R. P. (1990). Role of mucosal mast cells in intestinal graft-versus-host reaction in mice. Int. Arch. Allergy Appl. Immunol., 98, 308–13

    Article  Google Scholar 

  76. Klein, R. M., Clancy, J. and Sheridan, K. (1984). Acute lethal graft-versus-host disease stimulates cellular proliferation in Peyer’s patches and follicle associated ileal epithelium of adult rats. Virch. Arch. (B), 47, 303–11

    Article  CAS  Google Scholar 

  77. Abedi, M. R, Hammarstrom, L, Ringden, O. and Smith, C. I. E. (1990). Development of IgA deficiency after bone marrow transplantation. The influence of acute and chronic graft-versus-host disease. Transplantation, 50, 415–21

    Article  PubMed  CAS  Google Scholar 

  78. Strobel, S. (1984). PhD thesis, University of Edinburgh

    Google Scholar 

  79. Korngold, R. and Sprent, J. (1987). T cell subsets and graft-versus-host disease. Transplantation, 44, 335–9

    Article  PubMed  CAS  Google Scholar 

  80. Mowat, A. Mcl., Borland, A. and Parrott, D. M. V. (1986). Hypersensitivity reactions in the small intestine. 7. The intestinal phase of murine graft-versus-host reactions is induced by Lyt2− T cells activated by I-A alloantigens. Transplantation, 4, 192–8

    Article  Google Scholar 

  81. Mowat, A. Mcl. and Sprent, J. (1989). Induction of intestinal graft-versus-host reactions across mutant major histocompatibility antigens by T lymphocyte subsets in mice. Transplant, 47, 857–63

    Article  CAS  Google Scholar 

  82. Borland, A., Mowat, A. Mcl. and Parrott, D. M. V. (1983). Augmentation of intestinal and peripheral natural killer cell activity during the graft-versus-host reaction in mice. Transplantation, 36, 513–19

    Article  PubMed  CAS  Google Scholar 

  83. Felstein, M. V. and Mowat, A. Mcl. (1990). Experimental studies of immunologically mediated enteropathy. VI. Inhibition of acute intestinal graft-versus-host reaction in mice by 2’-deoxyguanosine. Scand. J. Immunol., 32, 461–9

    Article  PubMed  CAS  Google Scholar 

  84. Garside, P., Felstein, M. V., Green, E. A. and Mowat, A. Mcl. (1991). The role of interferon &#03B1;/&#03B2; in the induction of intestinal pathology in mice. Immunology (In press)

    Google Scholar 

  85. Mowat, A. Mcl. (1986). Ia+ bone marrow derived cells are the stimulus for the intestinal phase of murine graft-versus-host reaction. Transplantation, 42, 141–4

    Article  PubMed  CAS  Google Scholar 

  86. Cornelius, E. A., Martinez, C, Yunis, E. J. and Good, R. A. (1968). Haematological and pathological changes induced in tolerant mice by the injection of syngeneic lymphoid cells. Transplant, 6, 33–44

    Article  CAS  Google Scholar 

  87. Symington, F. W., Pepe, M. S., Chen, A. B. and Deliganis, A. (1990). Serum tumor necrosis factor alpha associated with acute graft-versus-host disease in humans. Transplantation, 50, 518–21

    Article  PubMed  CAS  Google Scholar 

  88. Mowat, A. Mcl. (1989). Antibodies to y-interferon prevent immunologically mediated intestinal damage in murine graft-versus-host reaction. Immunology, 68, 18–23

    PubMed  CAS  Google Scholar 

  89. Garside, P. A. and Mowat, A. Mcl. (1991). Pathological effects of tumour necrosis factor &#03B1; on the intestinal epithelium (Submitted)

    Google Scholar 

  90. Schoenfeld, Y. and Isenberg, D. A. (1989). The mosaic of autoimmunity. Immunol. Today, 10, 123–8

    Article  Google Scholar 

  91. Browning, J. and Ribolini, A. (1989). Studies on the differing effects of tumor necrosis factor and lymphotoxin on the growth of several human tumor lines. J. Immunol., 143, 1859–67

    PubMed  CAS  Google Scholar 

  92. Kvale, D., Lovhaug, D., Sollid, L. M. and Brandtzaeg, P. (1988). Tumor necrosis factor-a up-regulates expression of secretory component, the epithelial receptor for polymeric Ig. J. Immunol., 140, 3086–9

    PubMed  CAS  Google Scholar 

  93. Madara, J. L. and Stafford, J. (1989). Interferon-&#03B3; directly affects barrier function of cultured intestinal epithelial monolayers. J. Clin. Invest., 83, 724–7

    Article  PubMed  CAS  Google Scholar 

  94. Haffen, K., Kedinger, M. and Simon-Assmann, P. (1989). Cell contact dependent regulation of enterocytic differentiation. In Lebenthal, E. (ed.), Human Gastrointestinal Development. New York: Raven Press, pp. 19–39

    Google Scholar 

  95. Roy, C, Ghayur, T., Kongshavn, P. A. L. and Lapp, W. S. (1982). Natural killer activity by spleen lymph node and thymus cells during the graft-versus-host reaction. Transplantation, 34, 144–6

    Article  PubMed  CAS  Google Scholar 

  96. Kubota, E., Ishikawa, H. and Saito, K. (1983). Modulation of F1 cytotoxic potentials by GvHR. Host and donor-derived cytotoxic lymphocytes arise in the unirradiated Fl host spleens under the condition of GvHR-associated immunosuppression. J. Immunol., 131,1142–8

    PubMed  CAS  Google Scholar 

  97. Mowat, A. Mcl., Borland, A. and Parrott, D. M. V. (1985). Augmentation of natural killer cell activity by anti-host delayed-type hypersensitivity during the graft-versus-host reaction in mice. Scand. J. Immunol., 22, 389–99

    Article  PubMed  CAS  Google Scholar 

  98. Mowat, A. Mcl. and Felstein, M. V. (1987). Experimental studies of immunologically mediated enteropathy. II. Role of natural killer cells in the intestinal phase of murine graft-versus-host reaction. Immunology, 68, 179–83

    Google Scholar 

  99. Handa, K., Suzuki, R., Matsui, H., Shimizu, Y. and Kumagi, K. (1983). Natural killer (NK) cells as a responder to interleukin 2 (IL2). II. IL2-induced interferon production. J. Immunol., 130, 988–92

    PubMed  CAS  Google Scholar 

  100. Kasahara, T., Djeu, J. Y., Dougherty, S. F. and Oppenheim, J. J. (1983). Capacity of human large granular lymphocytes to produce multiple lymphokines: interleukin 2, interferon and colony stimulating factor. J. Immunol., 131, 2379–85

    PubMed  CAS  Google Scholar 

  101. Jones, J. M., Wilson, R. and Bealmear, P. M. (1971). Mortality and gross pathology of secondary disease in germfree mouse radiation chimeras. Radiat. Res., 45, 577–88

    Article  PubMed  CAS  Google Scholar 

  102. van Bekkum, D. W., Roodenburg, J., Heidt, P. J. and van der Waalt, D. (1974). Mitigation of secondary disease of allogeneic mouse radiation chimeras by modification of the intestinal microflora. J. Natl. Cancer Inst., 52, 401

    PubMed  Google Scholar 

  103. Moore, R. H., Lampert, I. A, Chia, Y., Aber, V. R. and Cohen, J. (1987). Influence of endotoxin on graft-versus-host disease after bone marrow transplantation across major histocompatibility barriers in mice. Transplantation, 43, 731–6

    Article  PubMed  CAS  Google Scholar 

  104. Moore, R. H., Mapert, I. A., Chia, Y., Aber, V. R. and Cohen, J. (1987). Effect of immunisation with Escherichia coli J5 on graft-versus-host disease induced by minor histocompatibility antigens in mice. Transplantation, 44, 249–53

    Article  PubMed  CAS  Google Scholar 

  105. Kawakami, M. and Cerami, A. (1981). Studies of endotoxin-induced decrease in lipoprotein lipase activity. J. Exp. Med., 154, 631

    Article  PubMed  CAS  Google Scholar 

  106. Le, J. and Vilcek, J. (1987). Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities. Lab. Invest., 56, 234–48

    PubMed  CAS  Google Scholar 

  107. Buckner, C. D., Clift, R. A., Sanders, J. E., Meyers, J. D., Counts, G. W., Farewell, V. T. and Thomas, E. D. (1978). Protective environment for marrow transplant recipients. A prospective study. Ann. Intern. Med., 89, 893–901

    PubMed  CAS  Google Scholar 

  108. Mowat, A. Mcl., Felstein, M. V. and Baca, M. E. (1987). Experimental studies of immunologically mediated enteropathy. III. Severe and progressive enteropathy during a graft-versus-host reaction in athymic mice. Immunology, 61, 185–8

    PubMed  CAS  Google Scholar 

  109. Bellgrau, D. and Wilson, D. B. (1978). Immunological studies of T-cell receptors. I. Specifically induced resistance to graft-versus-host disease in rats mediated by host T-cell immunity to alloreactive parental T cells. J. Exp. Med., 148, 103–14

    Article  PubMed  CAS  Google Scholar 

  110. Mowat, A. Mcl. (1984). The immunopathogenesis of food sensitive enteropathies. In Newby, T. J. and Stokes, C. R. (eds), Local Immune Responses of the Gut. Boca Raton, FL: CRC Press, pp. 199–225

    Google Scholar 

  111. MacDonald, T. T., Hutchings, P., Choy, M.-Y., Murch, S. and Cooke, A. (1990). Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine. Clin. Exp. Immunol., 81, 301–5

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. A. Mcl. Mowat
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Paediatric Gastroenterology, St. Bartholomew’s Hospital, London, UK

    T. T. MacDonald

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Mowat, A.M. (1992). Intestinal graft-versus-host disease. In: MacDonald, T.T. (eds) Immunology of Gastrointestinal Disease. Immunology and Medicine Series, vol 19. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2978-7_7

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-2978-7_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5323-5

  • Online ISBN: 978-94-011-2978-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation