Abstract
In man, several disorders can lead to excess tissue iron deposition, including genetic hemochromatosis (GH) and the various causes of secondary hemochromatosis that is chronic transfusion dependent anemias, sideroblastic anemia, alcoholic cirrhosis and porphyria cutanea tarda (PCT) (1). In all these conditions liver damage is a common finding. Clinical and experimental data indicate that iron is involved in the pathogenesis of hepatic fibrosis, cirrhosis and consequently hepatocellular carcinoma (HCC). GH which is a hereditary disease characterized by severe iron overload and which is much more common than was originally thought (about 1 in 220 white Northern Europeans is affected (2)), can be considered as a representative model of iron induced liver disease. Whereas the role of iron is clear in GH, in PCT and iron loading anemia it is less clear whether iron acts as a cofactor in the pathogenesis of liver damage in other conditions as chronic alcoholic and viral liver diseases.
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References
Halliday J.W., Powell L.W. (1982): Sem. Haematol., 19: 42–45
Edwards C.Q., Griffen L.M., Goldard D., Drummond C., Skalnick M.H., Kushner J.P. (1988): N. Engl. J. Med., 318: 1355–1362.
Niederau C., Fisher R., Sonnemberg A., Stremmel W., Trampisch H.J., Strohmeyer J. (1985): N. Engl. J. Med., 313: 1252–1262.
Basset M.L., Halliday J.W., Powell L.W. (1986): Hepatology, 6: 24–29.
Bacon B.R., Britton R.S. (1990): Hepatology, 11: 123–137.
Mulligan M., Althouse B., Linder M.C. (1986): Int. J. Biochem., 18: 791–798.
Weintraub L.R., Goral A., Grasso J., Granzblau C., Sulliwan A., Sulliwan S. (1985): Br. J. Haematol., 59: 321–331.
Pietrangelo A., Rocchi E., Schiaffonati L., Ventura E., Cairo G. (1990): Hepatology, 11: 798–804.
Stevens R.J., Johns Y., Micozzi M.S., Taylor P.R. (1988): N. Engl. J. Med., 319: 1047–1052.
Selby J.V., Friedman G.D. (1988): Int. J. Cancer, 41: 677–682.
Loeb L.A., James E.A., Weltersdorph A.M., Klebanoff S.J. (1988): Proc. Natl. Acad. Sci. USA, 85: 3918–3922.
Crawford D., Zbinden I., Amstad P., Cerutti P. (1988): Oncogene, 3: 27–32.
Fargion S., Piperno A., Fracanzani A.L., Cappellini M.D., Romano R., Fiorelli G. (1991): It. J. Gastroenterol., 23 (in press).
Piperno A., D’Alba R., Roffi L., Pozzi M., Farina A., Vecchi L., Fiorelli G. (1991): Arch. Virol., (in press).
Cohen A. (1990): Sem. Haematol., 27: 86–90.
Olivieri N.F., Buncic J.R., Chew E., Gallant T., Harrison R.W., Keenan L., Logan W., Mitchell D., Ricci G., Skarf B., Tailor M., Freedman M.H. (1986): N. Engl. J. Med., 314: 869–873.
Kontoghiorghes G.S. (1991) Eur. J. Clin. Invest., 21: 57
Olivieri N.F., Koren G., Hermann C., Bentur Y., Chung D., Klein J., St. Louis P., Freedman M.H., Mc Clelland R.A., Tempton D.M. (1990): Lancet, 336: 1275–1279.
Editorial. (1989): Lancett, ii: 1016–1017.
Ridson R.A., Barry M., Flynn D. (1974) Am. J. Pathol 116: 83–95.
Le Sage C.D., Baldus W.P., Green J.F. (1989): Hepatology, 10: 575.
Stal P., Glaumann H., Hultcrantz R. (1990): J.Hepathol., 11: 172–180.
Weimberg K. (1990): Am. J. Pedriat. Haematol. Onc., 12: 9–13.
Schwartz K.B., Korba B. (1990): Hepatology, 12: 972.
Tabor E., Epstein J.S., Hewlett I.K., Lee S.F. (1991): Lancet, 337: 795.
Baruchel S., Gao Q., Wainberg M.A. (1991): Lancet, 337: 1350.
Hann H.W.L., Stahlhut M.W., Hann C.L. (1990) Hepatology, 11: 566–569.
Hann H.W.L., Stahlhut M.W., Maddrey W.C. (1990): Hepatology, 12: 912.
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Fiorelli, G. et al. (1993). Treatment of Iron Dependent Chronic Liver Disease. In: Galmarini, D., Fassati, L.R., Paoletti, R., Sherlock, S. (eds) Drugs and the Liver: High Risk Patients and Transplantation. Medical Science Symposia Series, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1994-8_21
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DOI: https://doi.org/10.1007/978-94-011-1994-8_21
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