Abstract
Sulfate esterification of bile acids in the liver decreases their entero-hepatic circulation and enhances their fecal excretion. However, the intestinal microflora is capable of hydrolyzing these sulfate esters and thus counteracting sulfate esterification process by the liver and the elimination of toxic bile acids such as lithocholate. We have isolated sulfatase-producing microorganisms from the rat and human fecal microflora, and we compared their substrate specificities in vitro. The influence of bile acid desulfation by Clostridium sp. S2 on bile acid metabolism was studied in vivo in female gnotobiotic rats. In these rats the half-lifes of [14C]-labeled sulfated and unsulfated taurolithocholate was determined following their intraperitoneal (i.p.) injection.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Lindstedt S, Norman A. Acta fysiol. Scand. 38:121–128, 1956.
Huijghebaert SM, Mertens JA, Eyssen HJ. Appl. Environ. Microbiol. 43: 185–192, 1982.
Robben J, Parmentier G, Eyssen H. Appl. Environ. Microbiol. 51:32–38, 1986.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Martinus Nijhoff Publishers, Dordrecht
About this chapter
Cite this chapter
Robben, J., Van Eldere, J., Eyssen, H. (1987). Bile Acid Desulfation by the Gut Microflora. In: De Clercq, E. (eds) Frontiers in Microbiology. New Perspectives in Clinical Microbiology, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3353-8_25
Download citation
DOI: https://doi.org/10.1007/978-94-009-3353-8_25
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8006-4
Online ISBN: 978-94-009-3353-8
eBook Packages: Springer Book Archive