Abstract
The fundamental problem associated with cardiac transplantation is undoubtedly the prevention and treatment of rejection, both acute and chronic. Anti-rejection therapy leads to complications, notably infection and, to a lesser extent, malignant tumor formation. There are many other potential complications, however, that are related to the transplantation operation or, particularly, to the immunocompromised status of the patient. These complications will be outlined and discussed below in the light of our own experience (at Oklahoma Transplantation Institute).
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References
Ross, D. (1968). Report of a heart transplant operation. Am. J. Cardiol., 22, 838
Cooper, D.K.C, Fraser, R.C, Rose, A.G, Ayzenberg, T, Oldfield, G, Hassoulas, J, Novitzky, D, Uys, C.J. and Barnard, C.N. (1982). Technique, complications and clinical value of endomyocardial biopsy in patients with heterotopic heart transplants. Thorax, 37, 727
Zuhdi, N, Shrago, S.S, Clark, R.N, Voda, J, Greer, A.E, Chaffin, J.S, Novitzky, D. and Cooper, D.K.C. (1989). Experience with endomyocardial biopsy in 23 patients with heart transplants. J. Okla. Med. Assoc., 82, 109
Fitchett, D.H, Forbes, C. and Guerraty, AJ. (1988). Repeated endomyocardial biopsy causing coronary arterial-right ventricular fistula after cardiac transplantation. Am. J. Cardiol., 62, 829
Sandhu, J.S, Uretsky, B.F, Zerbe, T.R, Goldsmith, A.S, Reddy, P.S, Kormos, R.L, Griffith, B.P. and Hardesty, R.L. (1989). Coronary artery fistula in the heart transplant patient. A potential complication of endomyocardial biopsy. Circulation, 79, 350
Henzlova, M.J, Nath, H., Bucy, R.P, Kirklin, J.K. and Rogers, W.J.(1989). Coronary artery to right ventricle fistulae in heart transplant recipients: a complication of endomyocardial biopsy? (Abstract). J. Am. Coll. Cardiol. 13, 243A
Locke, T.J., Furniss, S.S. and McGregor, C.G.A. (1988). Coronary artery-right ventricular fistula after endomyocardial biopsy. Br. Heart J., 60, 81
Griffith, B.P, Hardesty, R.L, Thompson, M.E, Dummer, J.S. and Bahnson, H.T. (1983). Cardiac transplantation with cyclosporine: the Pittsburgh experience. Heart Transplant., 2, 251
Green, C.F. (1981). Cyclosporin-A. In Salaman, J.R. (ed.) Immunosuppressive Therapy. p. 75. (Lancaster: MTP Press)
Thompson, C.B, June, C.H, Sullivan, K.M. and Thomas, E.D. (1984). Association between cyclosporin neurotoxicity and hypomagnesaemia. Lancet, 2, 1116
Schmitz, N, Eulen, H.H. and Loffler, H. (1985). Hypomagnesaemia and cyclosporin toxicity (Letter). Lancet, 1, 103
de Groen, F.C, Aksamit, A.J, Rakela, J, Forbes, G.S. and Krom, R.A.F. (1987). Central nervous system toxicity after liver transplantation: the role of cyclosporine and cholesterol. N. Engl. J. Med., 317, 861
Cooper, D.K.C, Novitzky, D, Davis, L, Huff, J.E, Parker, D, Schlesinger, R, Sholer, C. and Zuhdi, N. (1989). Does central nervous system toxicity occur in hypocholesterolemic transplant patients receiving cyclosporine? J. Heart Transplant., 8, 221
Billingham, M.I. (1987). Cardiac transplant atherosclerosis. Transplant. Proc., 19, 19
Ballantyne, C.M, Jones, P.H, Payton-Ross, C, Patsch, W, Short, H.D, Noon, G.P, Gotto, A.M., Jr., Debakey, M.E. and Young, B.(1987). Hyperlipidemia following heart transplantation: natural history and intervention with mebinolin (lovastatin). Transplant. Proc., 19, 60
Grady, K.L. and Herold, L.S. (1987). Comparison of nutritional status in patients before and after cardiac transplantation. Circulation, 76, IV–145
Becker, D.M, Markakis, M, Sension, M, Vitalis, S, Baughman, K, Swank, R, Kwiterovich, P.O., Pearson, T.A, Achuff, S.C, Baumgartner, W.A, Borkon, A.M., Reitz, B.A. and Traill, T.A. (1987). Prevalence of hyperlipidemia in heart transplant recipients. Transplantation, 44, 323
Norman, D.J, Illingworth, D.R, Munson, J. and Hosenpud, J. (1988). Myolysis and acute renal failure in a heart-transplant recipient receiving lovastatin (Letter). N. Engl. J. Med., 318, 46
East, C, Alivizatos, P.A, Grundy, S.M, Jones, P.H. and Farmer, J.A.(1988). Rhabdomyolysis in patients receiving lovastatin after cardiac transplantation (Letter). N. Engl. J. Med., 318, 47
Penn, I. and Makowski, E.L. (1981). Parenthood in kidney and liver transplant recipients. Transplant. Proc., 13, 36
Rhenman, M.J, Rhenman, B, Icenogle, T, Christensen, R. and Copeland, J. (1988). Diabetes and heart transplantation. J. Heart Transplant., 7, 356
Fisher, D.E. and Bickel, W.H. (1971). Corticosteroid-induced avascular necrosis — a clinical study of seventy-seven patients. J. Bone J. Surg., 53A, 859
Fisher, D.E, Bickel, W.H, Holley, K.E. and Ellefson, R.D. (1972). Corticosteroid-induced necrosis. II. Experimental study. Clin. Orthop., 84, 200
Briggs, W.A, Hampers, C.L, Merrill, J.P, Hagen, E.B, Wilson, R.E, Birtch, A.G. and Murray, J.E. (1972). Aseptic necrosis in the femur after renal transplantation. Ann. Surg., 175, 282
Solomon, L. (1973). Drug-induced arthropathy and necrosis of the femoral head. J. Bone J. Surg., 55B, 246
Burton, D.S, Mochizuki, R.M. and Helpern, A.A. (1978). Total hip arthroplasty in the cardiac transplant patient. Clin. Orthop., 130, 186
Morris, P.J, Oliver, D.O, Bishop, M, Cullen, P, Fellows, G, French, M, Ledingham, J.G, Smith, J.C, Ting, A. and Williams, K. (1978). Results from a new renal transplantation unit. Lancet, 2, 1353
Merrill, J.P. (1978). Dialysis versus transplantation in the treatment of end-stage renal disease. Annu. Rev. Med., 29, 243
Jamieson, S.W, Bieber, C.P. and Oyer, P.E. (1981). Suppression of immunity for cardiac transplantation. In Salaman, J.R. (ed.) Immunosuppressive Therapy pp. 177–179. (Lancaster: MTP Press)
Hess, M.L, Hastillo, A, Goldman, M, Rider, S, Mohanakumar, T, Ducey, K, Wolfgang, T, Szentpetery, S. and Lower, R.R. (1983). Cardiac transplantation at the Medical College of Virginia. Heart Transplant., 2, 246
Cabrol, C, Gandjbakhch, I, Pavie, A, Cabrol, A, Matter, M.F, Lienhart, A, Gluckman, J.C. and Rottembourg, J. (1983). Cardiac transplantation at La Pitie Hospital. Heart Transplant., 2, 244
Crosnier, J. and Broyer, M. (1979). Treatment of chronic renal failure in children. In Hamburger, J, Crosnier, J. and Grunfield, J.P. (eds.) Nephrology. p. 1361. (New York: Wiley)
Blodgett, F.M, Burgin, L, Tezzoni, D, Oribetz, D. and Talbot, N.B. (1956). Effects of prolonged cortisone therapy on the statural growth, skeletal maturation and metabolic status of children. N. Engl. J. Med., 254, 636
Soyka, L.F. and Saxena, K.M. (1965). Alternate-day steroid therapy for nephrotic children. J. Am. Med. Assoc., 192, 225
Potter, D.E, Holliday, M.A, Wilson, C.J, Salvatierra, O. and Belzer, F.O. (1975). Alternate-day steroids in children after renal transplantation. Transplant. Proc., 7, 79
Copeland, J, Fuller, J, Sailor, M.J. and McAleer, M.J. (1983). Heart transplantation at the Health Sciences Center of the University of Arizona. Heart Transplant., 2, 246
Kirkman, R.L, Strom, T.B, Weir, M.R. and Tilney, N.L. (1982). Late mortality and morbidity in recipients of long-term renal allografts. Transplantation, 34, 347
Crosnier, J, Leski, M, Kreis, H. and Descamps, D. (1969). Non-renal complications of kidney allotransplantation. In Alwall, N. et al (eds.) Proceedings of the Fourth International Congress of Nephrology, Stockholm Vol. 3, p. 270. (Basel and New York: Karger)
Abele, R, Novick, A.C, Braun, W.E, Steinmuller, D, Buszta, C, Greenstreet, R. and Hinton, J. (1982). Long-term results of renal transplantation in recipients with a functioning graft for two years. Transplantation, 34, 264
Debnath, S.C, Abomelha, M.S., Jawdat, M, Chang, R. and Al-Khader, A.A. (1987). Ocular side effects of systemic steroid therapy in renal transplant patients. Ann. Ophthalmol., 19, 435
Luntz, M.H. (1980). Clinical types of cataracts. In Duane, T.D. (ed.) Duane’s Series of Ophthalmology Volume 1, pp. 15 and 19. (Phildelphia: Lippincott)
Quarton, G.C, Clark, L.D, Cobb, S. and Bauer, W. (1955). Mental disturbance associated with ACTH and cortisone: a review of explanatory hypotheses. Medicine, 34, 13
Ritchie, E.A. (1956). Toxic psychosis under cortisone and corticotropin. J. Ment. Sci., 102, 830
Bourne, M.S. and Dawson, H. (1958). Acute pancreatitis complicating prednisolone therapy. Lancet, 2, 1209
Mallory, A. and Kern, F. (1980). Drug-induced pancreatitis: a critical review. Gastroenterology, 78, 813
Nakashima, Y. and Howard, J.M. (1977). Drug-induced acute pancreatitis. Surg. Gynecol. Obstet., 145, 105
Kawanishi, H, Rudolph, E. and Bull, F.E. (1973). Azathioprine-induced acute pancreatitis. N. Engl. J. Med., 289, 357
Jones, P.F. and Oelbaum, M.H. (1975). Furosemide-induced pancreatitis. Br. Med. J., 1, 133
Tilney, N.L, Collins, J.J. and Wilson, R.E. (1966). Hemorrhagic pancreatitis: a fatal complication of renal transplantation. N. Engl. J. Med., 275, 1051
Hume, D.M. (1968). Kidney transplantation. In Rapaport, F.T. and Dausset, J. (eds.) Human Transplantation p. 110. (New York: Grune and Stratton)
Werbitt, W. and Mohsenifar, Z. (1980). Mononucleosis pancreatitis. South. Med. J., 73, 1094
Imrie, C.W, Ferguson, J.C. and Sommerville, R.G. (1977). Coxsackie and mumps virus infection in a prospective study of acute pancreatitis. Gut, 18, 53
Fujii, G. and Nelson, R.A. (1963). The cross-reactivity and transfer of antibody in transplantation immunity. J. Exp. Med., 118, 1037
Amos, D.B. and Stickel, D.L. (1968). Human transplantation antigens. Adv. Intern. Med., 14, 15
Feiner, H. (1976). Pancreatitis after cardiac surgery. Am. J. Surg., 131, 684
Karrer, F.M., Mammana, R.B. and Copeland, J.G. (1982). Survival following pancreatitis and surgical drainage of a pancreatic pseudocyst in a heart transplant recipient. Heart Transplant., 1, 325
Uys, C.J., Rose, A.G. and Barnard, C.N. (1979). The pathology of human cardiac transplantation. S. Afr. Med. J., 56, 887
Bristow, M.R., Gilbert, E.M., Renlund, D.G., De Witt, C.W., Burton, N.A. and O’Connell, J.B. (1988). Use of OKT3 monoclonal antibody in cardiac transplantation: review of the initial experience. J. Heart Transplant., 7, 1
Koranda, F.C., Dehmel, E.M., Kahn, G. and Penn, I. (1974). Cutaneous complications in immunosuppressed renal homograft recipients. J. Am. Med. Assoc., 229, 419
Spencer, E.S. and Anderson, H.K. (1970). Clinically evident, nonterminal infections with herpes viruses and the wart virus in immunosuppressed renal allograft recipients. Br. Med. J., 3, 251
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Cooper, D.K.C., Muchmore, J.S., Welch, R.W. (1990). Other Complications of Transplantation and Immunosuppressive Therapy. In: Cooper, D.K.C., Novitzky, D. (eds) The Transplantation and Replacement of Thoracic Organs. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0711-9_22
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DOI: https://doi.org/10.1007/978-94-009-0711-9_22
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