Skip to main content
SpringerLink
Log in

Development and Aging Are Oxygen-Dependent and Correlate with VEGF and NOS along Life Span

  • Conference paper
  • First Online:
Respiratory Regulation - The Molecular Approach

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 756))

Abstract

During development and aging, vascular remodeling represents a critical adaptive response to modifications in oxygen supply to tissues. Hypoxia inducible factor (HIF) has a crucial role and is modulated by oxygen levels, with an age-dependent response in neonates, adult, and aged people. ROS are generated under hypoxic conditions and the accumulation of free radicals during life reduces the ability of tissues to their removal. In this immunohistochemical study we investigated the presence and localization of VEGF and iNOS in human carotid bodies (CB) sampled at autopsy from three children (mean age – 2 years), four adult young subjects (mean age – 44.3 years), and four old subjects (mean age – 67.3 years). VEGF immunoreactivity was significantly enhanced in CB tissues from the children (7.2 ± 1.2%) and aged subjects (4.7 ± 1.7%) compared with the young adults (1.4 ± 0.7%). On the other hand, iNOS immunoreactivity was enhanced in CB tissues from the children (0.4 ± 0.04%) and young adult subjects (0.3 ± 0.02%) compared with the old subjects (0.2 ± 0.02%). Prevention of oxygen desaturation, reducing all causes of hypoxemia from neonatal life to aging would decrease the incidence of diseases in the elderly population with lifespan extension.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Amicarelli, F., Ragnelli, A. M., Aimola, P., Bonfigli, A., Colafarina, S., Di Ilio, C., & Miranda, M. (1999). Age-dependent ultrastructural alterations and biochemical response of rat skeletal muscle after hypoxic or hyperoxic treatments. Biochimica et Biophysica Acta, 1453, 105–114.

    Article  PubMed  CAS  Google Scholar 

  • Babcock, M. A., Paterson, D. H., & Cunningham, D. A. (1992). Influence of ageing on aerobic parameters determined from a ramp test. European Journal of Applied Physiology and Occupational Physiology, 65, 138–143.

    Article  PubMed  CAS  Google Scholar 

  • Di Giulio, C., Grilli, A., Ciocca, I., Macrì, M. A., Daniele, F., Sabatino, G., Cacchio, M., Da Porto, R., Di Natale, F., & Felaco, M. (2000). Carotid body NO-CO interaction and chronic hypoxia. Advances in Experimental Medicine and Biology, 475, 685–690.

    Article  PubMed  Google Scholar 

  • Di Giulio, C., Cacchio, M., Bianchi, G., Rapino, C., & Di Ilio, C. (2005). Oxygen and life span: Chronic hypoxia and hyperoxia as models for studying VEGF, NOS and HIF during ageing. Respiratory Physiology & Neurobiology, 147, 31–38.

    Article  Google Scholar 

  • Finkel, T., & Holbrook, N. J. (2000). Oxidants, oxidative stress and the biology of ageing. Nature, 408, 239–247.

    Article  PubMed  CAS  Google Scholar 

  • Harman, D. (1992). Free radical theory of aging: History. Free Radical and Aging, 62, 1–10.

    Article  CAS  Google Scholar 

  • Jamieson, D. (1989). Oxygen toxicity and reactive oxygen metabolites in mammals. Free Radical Biology & Medicine, 7, 87–108.

    Article  CAS  Google Scholar 

  • Lahiri, S., Di Giulio, C., & Roy, A. (2002). Lessons from chronic intermittent and sustained hypoxia at high altitudes. Respiratory Physiology & Neurobiology, 130, 223–233.

    Article  Google Scholar 

  • Porzionato, A., Macchi, V., Guidolin, D., Parenti, A., Ferrara, S.D., & De Caro, R. (2005). Histopathology of carotid body in heroin addiction. Possible chemosensitive impairment. Histopathology, 46, 296–306.

    Google Scholar 

  • Richmonds, C. R., Boonyapisit, K., Kusner, L. L., & Kaminski, H. J. (1999). Nitric oxide synthase in aging rat skeletal muscle. Mechanisms of Ageing and Development, 109, 177–189.

    Article  PubMed  CAS  Google Scholar 

  • Semenza, G. L. (2009). Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology, 24, 97–106.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Drug Sciences, University of Chieti, Via dei Vestini 31, 66100, Chieti, Italy

    S. Zara

  2. Department of Respiratory Research, Medical Research Center, Polish Academy of Sciences, Pawinskiego 5 St, 02-106, Warsaw, Poland

    M. Pokorski & J. Antosiewicz

  3. Department of Neuropsychology, Institute of Psychology, Opole University, Plac Staszica 1, 45-052, Opole, Poland

    M. Pokorski

  4. Department of Medicine and Ageing Sciences, University of Chieti, Via dei Vestini 31, 66100, Chieti, Italy

    A. Cataldi

  5. Section of Anatomy, Department of Human Anatomy and Physiology, University of Padua, Gdansk, Poland

    A. Porzionato & R. De Caro

  6. Department of Neurosciences and Imaging, University of Chieti, Via dei Vestini 31, 66100, Chieti, Italy

    C. Di Giulio

Authors
  1. S. Zara
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Pokorski
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Cataldi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Porzionato
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. De Caro
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. Antosiewicz
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. C. Di Giulio
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to C. Di Giulio .

Editor information

Editors and Affiliations

  1. Medical Research Center, Respiratory Research, Polish Academy of Sciences, Pawinskiego 5, Warsaw, 02-106, Poland

    Mieczyslaw Pokorski

Additional information

Acknowledgments JA supported by grant NN401153938 from the Polish Ministry of Science and Higher Education.

Conflicts of interest :The authors declare no conflicts of interest in relation to this article.

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media Dordrecht

About this paper

Cite this paper

Zara, S. et al. (2013). Development and Aging Are Oxygen-Dependent and Correlate with VEGF and NOS along Life Span. In: Pokorski, M. (eds) Respiratory Regulation - The Molecular Approach. Advances in Experimental Medicine and Biology, vol 756. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4549-0_28

Download citation

Publish with us

Policies and ethics

Search

Navigation