Abstract
For more than a century heterocycles have constituted one of the largest areas of research in organic chemistry. The heterocyclic moieties are of exceptional interest in the pharmaceutical industry as they make up a core part of several drugs. The importance of heterocycles provides a significant basis for the development of new methods for their synthesis. Further, due to the strengthening environmental regulations and safety concerns, the industries are in need of new innovative, environmental friendly alternate routes for synthesizing the therapeutic and pharmacological important heterocyclics are desired. This environmentally benign synthesis can be easily designed using microwave methodology. The microwaves induce rapid heating and avoid the harsh classical conditions, resulting in the formation of cleaner products. The first chapter thus deals with the microwave theory, latest developments in instrumentation technology, the various microwave technologies used for synthesis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Adam D (2003) Microwave chemistry:out of the kitchen. Nature 421:571–572
Gedye RN, Smith F, Westaway K et al (1986) The use of microwave ovens for rapid organic synthesis. Tetrahedron Lett 27:279–282
Kappe CO, Stadler A (2005) Microwaves in organic and medicinal chemistry. Wiley-VCH, Weinheim
Varma RS (1999) Solvent-free organic syntheses Using supported reagents and microwave irradiation. Green Chem 1:43–55
Lidstrom P, Tierney J, Wathey B et al (2001) Microwave assisted organic synthesis—a review. Tetrahedron 57:9225–9283
NLchter M, Ondruschka B, Bonrath W et al (2004) Microwave assisted synthesis–a critical technology overview. Green Chem 6:128–141
Bose AK, Manhas MS, Ganguly SN et al (2002) More chemistry for less pollution: applications for process development. Synthesis 11:1578–1591
Hoz A, DWaz-Ortis A, Moreno A et al (2000) Cycloadditions under microwave irradiation conditions: methods and applications. Eur J Org Chem 2000:3659–3673
Xu Y, Guo XQ (2004) Syntheses of heterocyclic compounds under microwave irradiation. Heterocycles 63:903–974
Elander N, Jones JR, Lu SY et al (2000) Microwave-enhanced radiochemistry. Chem Soc Rev 29:239–249
Larhed M, Moberg C, Hallberg A (2002) Microwave-accelerated homogeneous catalysis in organic chemistry. Acc Chem Res 35:717–727
Wilson NS, Roth GP (2002) Recent trends in microwave-assisted synthesis. Curr Opin Drug Discovery Dev 5:620–629
Blackwell HE (2003) Out of the oil bath and into the oven—microwave-assisted combinatorial chemistry heats up. Org Biomol Chem 1:1251–1255
Loupy A (2002) Microwaves in organic synthesis. Wiley-VCH, Weinheim
Hayes BL (2002) Microwave synthesis: chemistry at the speed of light. CEM Publishing, Matthews
Lidstrum P, Tierney JP (2004) Microwave-assisted organic synthesis. Blackwell, Oxford
Villemin D, Thibault-Starzyk F (1991) Domestic microwave ovens in the laboratory. J Chem Educ 68:346
Deshayes S, Liagre M, Loupy A et al (1999) Microwave activation in phase transfer catalysis. Tetrahedron 55:10851–10870
Vidal T, Petit A, Loupy A et al (2000) Re-examination of microwave-induced synthesis of phthalimides. Tetrahedron 56:5473–5478
Sharma S, Gangal S, Rauf A (2008) Green chemistry approach to the sustainable advancement to the synthesis of heterocyclic chemistry. Rasayan J Chem 1:693–717
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2012 © The Author(s)
About this chapter
Cite this chapter
Rauf, A., Farshori, N.N. (2012). Introduction to Microwave Chemistry. In: Microwave-Induced Synthesis of Aromatic Heterocycles. SpringerBriefs in Molecular Science(), vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1485-4_1
Download citation
DOI: https://doi.org/10.1007/978-94-007-1485-4_1
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-007-1484-7
Online ISBN: 978-94-007-1485-4
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)