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The Role of Transient Receptor Potential Channels in Respiratory Symptoms and Pathophysiology

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Transient Receptor Potential Channels

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 704))

Abstract

The Transient Receptor Potential channels constitute a superfamily of ion channels that is unmatched in its functional diversity. Recent research employing pharmacological and genetic methods has demonstrated that these channels are widely distributed within the respiratory tract, where they may mechanistically link noxious irritant exposures and inflammation to heightened airway reflex sensitivity, pathological remodeling and airflow limitation. Herein, we summarize the state of the art in this rapidly expanding area, emphasizing the known roles of Transient Receptor Potential channels in airway sensory nerves in addition to highlighting their roles in non-excitable cells.

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Authors and Affiliations

  1. Respiratory Discovery Biology, GlaxoSmithKline Pharmaceuticals, King of Prussia, PA, USA

    M. Allen McAlexander

  2. Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL, USA

    Thomas Taylor-Clark

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  1. M. Allen McAlexander
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  1. Dept. Clinical Research & Education, Södersjukhuset, Karolinska Institutet, Stockholm, 118 83, Sweden

    Md. Shahidul Islam

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McAlexander, M.A., Taylor-Clark, T. (2011). The Role of Transient Receptor Potential Channels in Respiratory Symptoms and Pathophysiology. In: Islam, M. (eds) Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology, vol 704. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0265-3_50

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