Abstract
It has been reported that a natural reduced water derived from a deep well in Japan (trademark, Hita Tenryousui water®; Nakanoshima, Hita city, Oita, Japan) scavenged intracellular reactive oxygen species (ROS) and protected a hamster pancreas β cell line HIT-T15 from oxidative damage by alloxan, a type 1 diabetes inducer. Here we demonstrated that the water also suppressed the fasted blood glucose levels of the alloxan-induced type 1-diabetes mice. Protein tyrosine phosphatase (PTP) is a redox-regulatable signal enzyme and activation of PTP in Type 2-diabetes patients is noted to be responsible to inactivation of insulin receptor. Hita Tenryousui water® suppressed the PTP activity, leading the activation of insulin receptor. This water stimulated glucose uptake into myotubes and showed a tendency to improve the impaired sugar tolerance of Type 2-diabetes model mice. An open clinical test of Hita Tenryousui water® against 65 patients with hyperglycemia and 50 patients with hyperlipemia for 2 months resulted in significant improvement of impaired blood sugar, plasma triglycerol and total cholesterol levels (P<0.05). These facts suggest that daily intake of natural reduced water will be beneficial to prevent and improve diabetes mellitus.
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Osada, K. et al. (2010). Anti-Diabetes Effects of Hita Tenryou-Sui Water®, a Natural Reduced Water. In: Kamihira, M., Katakura, Y., Ito, A. (eds) Animal Cell Technology: Basic & Applied Aspects. Animal Cell Technology: Basic & Applied Aspects, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3892-0_51
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DOI: https://doi.org/10.1007/978-90-481-3892-0_51
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