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HCV Infection and Cryoglobulinemia pp 185–190Cite as

Rheumatologic Symptoms in Patients with Mixed Cryoglobulinemia

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Abstract

Chronic hepatitis C virus (HCV) infection is frequent worldwide and causes hepatic damage as well as a wide spectrum of extrahepatic manifestations. This capacity of the infection to determine several extrahepatic comorbidities was demonstrated early after discovery of the infectious agent and appears to be related to its ability to infect immune cells, namely B cells. This can lead to their abnormal activation and end in an autoimmune or lymphoproliferative disease. The strict link between HCV and mixed cryoglobulinemia (MC) is well known. In addition, it is clear that many symptoms of rheumatologic interest can be present in the setting of chronic HCV infection, such as arthralgias and fatigue. In some cases, as in sicca syndrome, MC manifests as a true infectious-related autoimmune disease. Here we review the main rheumatic symptoms that can occur during MC (HCV chronic infection) and discuss the principles underlying their clinical management.

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Authors and Affiliations

  1. Division of Rheumatology, Institute of Rheumatology and Affine Sciences (IRSA), School of Medicine, CIC – Catholic University of the Sacred Heart, Rome, Italy

    Gianfranco Ferraccioli & Elisa Gremese

  2. Division of Rheumatology, Institute of Rheumatology and Affine Sciences (IRSA), CIC – Catholic University of the Sacred Heart, Rome, Italy

    Francesca Faustini

Authors
  1. Gianfranco Ferraccioli
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  2. Francesca Faustini
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  3. Elisa Gremese
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Corresponding author

Correspondence to Gianfranco Ferraccioli .

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Editors and Affiliations

  1. , Department of Internal Medicine and Clin, University of Bari, Piazza Giulio Cesare 11, Bari, 70124, Italy

    Franco Dammacco

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Ferraccioli, G., Faustini, F., Gremese, E. (2012). Rheumatologic Symptoms in Patients with Mixed Cryoglobulinemia. In: Dammacco, F. (eds) HCV Infection and Cryoglobulinemia. Springer, Milano. https://doi.org/10.1007/978-88-470-1705-4_23

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  • DOI: https://doi.org/10.1007/978-88-470-1705-4_23

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  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-1704-7

  • Online ISBN: 978-88-470-1705-4

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