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Current Research Perspectives in Understanding Diabetic Retinopathy

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Advances in Vision Research, Volume I

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

Abstract

Diabetic retinopathy (DR), one of the severe microvascular complications of diabetes, could be sightthreatening when not intervened at the earlier stages of the disease. With the persistent increase in the global prevalence of diabetes, DR pose a major public health concern and has been indicated as the 5th most common cause of blindness in the world. The review details the clinical features observed in DR , its classification and the associated risk factors that makes a diabetes person susceptible for retinopathy changes. The reveiw provides an overiew of the various strategies namely, gene mapping, expression profiling and animal models studies for diabetic retinopathy.

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References

  1. IDF Diabetes Atlas, 5th edition. International Diabetes Federation, 2011.

    Google Scholar 

  2. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047–53.

    Article  PubMed  Google Scholar 

  3. http://www.who.int/features/factfiles/diabetes/en/index.html

  4. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2009; 32:S62–S67.

    Google Scholar 

  5. Karvonen M, Viik-Kajander M, Moltchanova E, Libman I, LaPorte R, et al. (2000) Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group. Diabetes Care 23:1516–1526.

    Google Scholar 

  6. Maahs DM, West NA, Lawrence JM, Mayer-Davis EJ. Epidemiology of type 1 diabetes. Endocrinol Metab Clin N Am. 2010;39:481–97.

    Article  Google Scholar 

  7. http://www.idf.org/sites/default/files/The_Global_Burden.pdf

  8. Moore DJ, Gregory JM, Kumah-Crystal YA, Simmons JH. Mitigating micro-and macro-vascular complications of diabetes beginning in adolescence. Vasc Health Risk Manag. 2009;5:1015–31.

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Fowler MJ. Microvascular and macrovascular complications of Diabetes. Clin Diabetes. 2008;26(9):77–82.

    Article  Google Scholar 

  10. PKNg D. Human genetics of diabetic retinopathy: current perspectives. J Ophthalmol. 2010;10:1–6.

    Google Scholar 

  11. Resnikoff S, Pascolini D, Etyaale D, Kocur I, Pararajasegaram R, et al. Global data on visual impairment in the year 2002. Bull World Health Organ. 2004;82(11):844–51.

    PubMed  PubMed Central  Google Scholar 

  12. Yau JW, Rogers SL, Kawasaki R, Lamoureux EL, Kowalski JW, et al. Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care. 2012;35(12):556–64.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Rani PK, Raman R, Sharma V, Mahuli SV, Tarigopala A, Sudhir RR, et al. Analysis of a comprehensive diabetic retinopathy screening model for rural and urban diabetics in developing countries. Br J Ophthalmol. 2007;91(13):1425–9.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Ramasamy K, Raman R, Tandon M. Current state of care for diabetic retinopathy in India. Current diabetes reports. 2013;13(14):460–8.

    Article  PubMed  Google Scholar 

  15. Namperumalsamy P, Nirmalan PK, Ramasamy K. Developing a screening program to detect sight threatening diabetic retinopathy in South India. Diabetes Care. 2003;26:1831–5.

    Article  PubMed  Google Scholar 

  16. Wilkinson CP, Ferris 3rd FL, Klein RE, Lee PP, Agardh CD, Davis M, Dills D, Kampik A, Pararajasegaram R, Verdaguer JT. Global Diabetic Retinopathy Project Group. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology. 2003;110(16):1677–82.

    Article  CAS  PubMed  Google Scholar 

  17. Early Treatment Diabetic Retinopathy Study Research Group. Early photocoagulation for diabetic retinopathy, ETDRS report no. 9. Ophthalmology. 1991;98(17):766–85.

    Google Scholar 

  18. Klein R, Klein BE, Moss SE, et al. The Wisconsin epidemiological study of diabetic retinopathy. IX. Four-year incidence and progression of diabetic retinopathy when age of diagnosis is less than 30 years. Arch Ophthalmol. 1989;107(18):237–43.

    Article  CAS  PubMed  Google Scholar 

  19. Engerman RL. Pathogenesis of diabetic retinopathy. Diabetes. 1989;38:1203–6.

    Article  CAS  PubMed  Google Scholar 

  20. Cai J, Boulton M. The pathogenesis of diabetic retinopathy: old concepts and new questions. Eye. 2002;16:242–60.

    Article  CAS  PubMed  Google Scholar 

  21. Mohammad SO, Mohd IN. Cellular and molecular mechanism of diabetic retinopathy, diabetic retinopathy. In: Dr. Mohammad Shamsul Ola (Ed.), ISBN: 978–953–51-0044-7, InTech, Available from: http://www.intechopen.com/books/diabetic-retinopathy/cellular-and-molecular-mechanism-ofdiabetic-retinopathy

  22. Jackson GR, Scott IU, Quillen DA, Walter LE, Gardner TW. Inner retinal visual dysfunction is a sensitive marker of non-proliferative diabetic retinopathy. Br J Ophthalmol. 2012;96:699–703.

    Article  PubMed  Google Scholar 

  23. Jackson GR, Barber AJ. Visual dysfunction associated with diabetic retinopathy. Cur Diabetes Rep. 2010;10:380–4.

    Article  Google Scholar 

  24. Han Y, Bearse Jr MA, Schneck ME, Barez S, Jacobsen CH, Adams AJ. Multifocal electroretinogram delays predict sites of subsequent diabetic retinopathy. Invest Ophthalmol Vis Sci. 2004;45:948–54.

    Article  PubMed  Google Scholar 

  25. Harrison WW, Bearse MA, Ng JS, et al. Multifocal electroretinograms predict onset of diabetic retinopathy in adult patients with diabetes. Invest Ophthalmol Vis Sci. 2011;52:772–7.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Agarwal S, Raman R, Paul PG, Rani PK, Uthra S, Gayathree R, McCarty C, Govindasamy K, Sharma T. Sankara Nethralaya—Diabetic Retinopathy Epidemiology and Molecular Genetic Study (SN-DREAMS 1): study design and research methodology. Ophthalmic Epidemiol. 2005;12:143–53.

    Article  PubMed  Google Scholar 

  27. Rani PK, Raman R, Chandrakantan A, Pal SS, Perumal GM, Sharma T. Risk factors for diabetic retinopathy in self-reported rural population with diabetes. J Postgrad Med. 2009;55:92–6.

    Article  CAS  PubMed  Google Scholar 

  28. Raman R, Rani PK, Rachepalle SR, Gnanamoorthy P, Uthra S, Kumaramanickavel G, Sharma T. Prevalence of diabetic retinopathy in India : Sankara Nethralaya diabetic retinopathy epidemiology and molecular genetics study report 2. Ophthalmology. 2009;116:311–8.

    Article  PubMed  Google Scholar 

  29. Raman R, Vaitheeswaran K, Vinita K, Sharma T. Is prevalence of retinopathy related to the age of onset of diabetes? Sankara Nethralaya diabetic retinopathy epidemiology and molecular genetic report no. 5. Ophthalmic Res. 2011;45:36–41.

    Article  CAS  PubMed  Google Scholar 

  30. Raman R et al. Association of obesity with diabetic retinopathy: Sankara nethralaya diabetic retinopathy epidemiology and molecular genetics study (SN-DREAMS Report no. 8). Acta Diabetol. 2010;47:209–15.

    Article  PubMed  Google Scholar 

  31. Raman et al. Prevalence of Metabolic Syndrome and its influence on microvascular complications in the Indian population with Type 2 Diabetes Mellitus. Sankara Nethralaya Diabetic Retinopathy Epidemiology And Molecular Genetic Study (SN-DREAMS, report 14). Diabetology & Metabolic Syndrome. 2010; 2:67.

    Google Scholar 

  32. Ganesan S, Raman R, Kulothungan V, Sharma T. Influence of dietary-fibre intake on diabetes and diabetic retinopathy: Sankara Nethralaya-Diabetic retinopathy epidemiology and molecular genetic study (report 26). Clin Exp Ophthalmol. 2012;40:288–94.

    Article  PubMed  Google Scholar 

  33. Raman R, Verma A, Pal SS, Gupta A, Vaitheeswaran K, Sharma T. Influence of glycosylated hemoglobin on sight-threatening diabetic retinopathy: a population-based study. Diabetes Res Clin Pract. 2011 May; 92(2):168–73.

    Google Scholar 

  34. Raman R, Rani PK, Kulothungan V, Rachepalle SR, Kumaramanickavel G, Sharma T. Influence of serum lipids on clinically significant versus nonclinically significant macular edema: SN-DREAMS report number 13. Ophthalmology. 2010;117.4:766–72.

    Article  Google Scholar 

  35. Raman R, Gupta A, Kulothungan V, Sharma T. Prevalence and risk factors of diabetic retinopathy in subjects with suboptimal glycaemic, blood pressure and lipid control. Sankara Nethralaya diabetic retinopathy epidemiology and molecular genetic study (SN-DREAMS, Report 33). Curr Eye Res. 2012;37:513–23.

    Article  CAS  PubMed  Google Scholar 

  36. Raman R, Gupta A, Krishna S, Kulothungan V, Sharma T. Prevalence and risk factors for diabetic microvascular complications in newly diagnosed type II diabetes mellitus. Sankara Nethralaya Diabetic Retinopathy Epidemiology And Molecular Genetic Study (SN-DREAMS, report 27). J Diabetes Complicat. 2012;26:123–8.

    Article  PubMed  Google Scholar 

  37. Ranil PK, Raman R, Rachepalli SR, Pal SS, Kulothungan V, Lakshmipathy P, Satagopan U, Kumaramanickavel G, Sharma T. Anemia and diabetic retinopathy in type 2 diabetes mellitus. J Assoc Physicians India. 2010;58:91–4.

    PubMed  Google Scholar 

  38. Lind M, Oden A, Fahlen M, Eliasson B. A systematic review of HbA1c variables used in the study of diabetic complications. Diabetes Metabol Syn: Clin Res Rev. 2008;2:282–93.

    Article  Google Scholar 

  39. Yu H, Li R, Zhang L, Chen H, Bao Y, et al. (2012) Serum CA19–9 level associated with metabolic control and pancreatic beta cell function in diabetic patients. Exp Diabetes Res. 2012; Article ID 745189:5 pages, doi:10.1155/2012/745189.

  40. Penno G, Solini A, Zoppini G, Orsi E, Fondelli C, et al. Hemoglobin A1c variability as an independent correlate of cardiovascular disease in patients with type 2 diabetes: a cross-sectional analysis of the renal insufficiency and cardiovascular events (RIACE) Italian multicenter study. Cardiovasc Diabetol. 2013;2:98.

    Article  Google Scholar 

  41. White NH, Sun W, Cleary PA, Danis RP, Davis MD, et al. Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the Diabetes Control and Complications Trial. Arch Ophthalmol. 2008;126:1707–15.

    Article  PubMed  Google Scholar 

  42. Bonora E, Tuomilehto J. The pros and cons of diagnosing diabetes with A1C. Diabetes Care. 2011;34:184–90.

    Article  Google Scholar 

  43. Zhang L, Krzentowski G, Albert A, Lefebvre PJ. Risk of developing retinopathy in Diabetes Control and Complications Trial type 1 diabetic patients with good or poor metabolic control. Diabetes Care. 2001;24:1275–9.

    Article  CAS  PubMed  Google Scholar 

  44. Lachin JM, Genuth S, Nathan DM, Zinman B, Rutledge BN. Effect of glycaemic exposure on the risk of microvascular complications in the diabetes control and complications trial - revisited. Diabetes. 2008;57:995–1001.

    Article  CAS  PubMed  Google Scholar 

  45. Rema M, Pradeepa R. Diabetic retinopathy: an Indian perspective. Indian J Med Res. 2007;125:297–310.

    CAS  PubMed  Google Scholar 

  46. Cheung N, Mitchell P, Wong TY. Diabetic retinopathy. Lancet. 2010;376:124–36.

    Article  PubMed  Google Scholar 

  47. Hallman DM, Huber Jr JC, Gonzalez VH, Klein BEK, Klein R, et al. Familial aggregation of severity of diabetic retinopathy in Mexican Americans from Starr County, Texas. Diabetes Care. 2005;28:1163–8.

    Article  PubMed  Google Scholar 

  48. Patel A, MacMahon S, Chalmers J, Neal B, Woodward M, et al. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial. Lancet. 2007;370:829–40.

    Article  CAS  PubMed  Google Scholar 

  49. Keenan HA, Costacou T, Sun JK, Doria A, Cavellerano J, et al. Clinical factors associated with resistance to microvascular complications in diabetic patients of extreme disease duration: the 50-year medalist study. Diabetes Care. 2007;30:1995–7.

    Article  CAS  PubMed  Google Scholar 

  50. Wong TY, Liew G, Tapp RJ, Schmidt MI, Wang JJ, et al. Relation between fasting glucose and retinopathy for diagnosis of diabetes: three population-based cross-sectional studies. Lancet. 2008;371:736–43.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Leslie RD, Pyke DA. Diabetic retinopathy in identical twins. Diabetes. 1982;31:19–21.

    Article  CAS  PubMed  Google Scholar 

  52. Hietala K, Forsblom C, Summanen P, Groop PH. Heritability of proliferative diabetic retinopathy. Diabetes. 2008;57:2176–80.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Li J, Hu YH. Susceptibility genes for diabetic retinopathy. Int J Ophthalmol. 2009;2:1–6.

    Google Scholar 

  54. Chiang PPC, Lamoureux EL, Cheung CY, Sabanayagam C, Wong W, et al. Racial differences in the prevalence of diabetes but not diabetic retinopathy in a multi-ethnic Asian population. Invest Ophthalmol Vis Sci. 2011;52:7586–92.

    Article  PubMed  Google Scholar 

  55. Harris MI, Klein R, Cowie CC, Rowland M, Byrd-Holt DD. Is the risk of diabetic retinopathy greater in non-Hispanic blacks and Mexican Americans than in non-Hispanic whites with type 2 diabetes? A U.S. population study. Diabetes Care. 1998;21:1230–5.

    Article  CAS  PubMed  Google Scholar 

  56. Emanuele N, Sacks J, Klein R, Reda D, Anderson R, et al. Ethnicity, race, and baseline retinopathy correlates in the Veterans Affairs Diabetes Trial. Diabetes Care. 2005;28:1954–8.

    Article  PubMed  Google Scholar 

  57. Daniel PKNg. Human genetics of diabetic retinopathy: current perspectives. J Ophthalmology. 2010; Article ID 172593, 6 pages, doi:10.1155/2010/172593.

  58. Daniel PKNg (2010) Human genetics of diabetic retinopathy: current perspectives. J Ophthalmol 1–6.

    Google Scholar 

  59. Kumaramanickavel G, Sripriya S, Vellanki RN, Upadyay NK, Badrinath SS, Rajendran V, Sukumar B, Ramprasad VL, Sharma T. Inducible nitric oxide synthase gene and diabetic retinopathy in Asian Indian patients.Clin Genet. 2002 May;61(5):344–8.

    Google Scholar 

  60. Kumaramanickavel G, Sripriya S, Vellanki RN, Upadyay NK, Badrinath SS, Arokiasamy T, Sukumar B, Vidhya A, Joseph B, Sharma T, Gopal L. Tumor necrosis factor allelic polymorphism with diabetic retinopathy in India.Diabetes Res Clin Pract. 2001 Nov;54(2):89–94.

    Google Scholar 

  61. Uthra S, Raman R, Mukesh BN, Rajkumar SA, Kumari PR, Lakshmipathy P, Gnanamoorthy P, Sharma T, McCarty CA, Kumaramanickavel G. Protein kinase C beta (PRKCB1) and pigment epithelium derived factor (PEDF) gene polymorphisms and diabetic retinopathy in a south Indian cohort. Ophthalmic Genet. 2010 Mar; 31(1):18–23.

    Google Scholar 

  62. Kumaramanickavel G, Ramprasad VL, Sripriya S, Upadyay NK, Paul PG, Sharma T. Association of Gly82Ser polymorphism in the RAGE gene with diabetic retinopathy in type IIdiabetic Asian Indian patients. J Diabetes Complications. 2002 Nov-Dec; 16(6):391–4.

    Google Scholar 

  63. Uthra S, Raman R, Mukesh BN, Rajkumar SA, Kumari RP, Agarwal S, Paul PG, Lakshmipathy P, Gnanamoorthy P, Sharma T, McCarty CA, Kumaramanickavel G. Diabetic retinopathy and IGF-1 gene polymorphic cytosine-adenine repeats in a Southern Indiancohort. Ophthalmic Res. 2007;39(5):294–9.

    Article  CAS  PubMed  Google Scholar 

  64. Kumaramanickavel G, Sripriya S, Ramprasad VL, Upadyay NK, Paul PG, Sharma T. Z-2 aldose reductase allele and diabetic retinopathy in India. Ophthalmic Genet. 2003 Mar; 24(1):41–8.

    Google Scholar 

  65. Balasubbu S, Sundaresan P, Rajendran A, Ramasamy K, Govindarajan G, Perumalsamy N, Hejtmancik JF. Association analysis of nine candidate gene polymorphisms in Indian patients with type 2 diabetic retinopathy. BMC Med Genet. 2010 Nov 10; 11:158.

    Google Scholar 

  66. Uthra S, Raman R, Mukesh BN, Padmaja Kumari R, Paul PG, Lakshmipathy P, Gnanamoorthy P, Sharma T, McCarty CA, Kumaramanickavel G. Intron 4 VNTR of endothelial nitric oxide synthase (eNOS) gene and diabetic retinopathy in type 2 patients in southern India. Ophthalmic Genet. 2007Jun; 28(2):77–81.

    Google Scholar 

  67. Uthra S, Raman R, Mukesh BN, Rajkumar SA, Kumari P, Lakshmipathy P, Gnanamoorthy P, Sharma T, McCarty CA, Kumaramanickavel G. Diabetic retinopathy: validation study of ALR2, RAGE, iNOS and TNFB gene variants in a south Indian cohort. Ophthalmic Genet. 2010 Dec; 31(4):244–51.

    Google Scholar 

  68. Yau JW, Rogers SL, Kawasaki R, Lamoureux EL, Kowalski JW, et al. Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care. 2012;35:556–64.

    Article  PubMed  PubMed Central  Google Scholar 

  69. Singh K, Kant S, Singh VK, Agrawal NK, Gupta SK, Singh K. Toll-like receptor 4 polymorphisms and their haplotypes modulate the risk of developing diabetic retinopathy in type 2 diabetes patients. Mol Vis. 2014 May 27; 20:704–13.

    Google Scholar 

  70. Hallman DM, Huber JC Jr, Gonzalez VH, Klein BE, Klein R, Hanis CL. Familial aggregation of severity of diabetic retinopathy in Mexican Americans from Starr County, Texas. Diabetes Care. 2005 May;28(5):1163–8.

    Google Scholar 

  71. Cheema BS, Kohli HS, Sharma R, Bhansali A, Khullar ME. Endothelial nitric oxide synthase gene polymorphism and type 2 diabetic retinopathy among Asian Indians. Acta Diabetol. 2012 Dec; 49(6):481–8.

    Google Scholar 

  72. Kuo JZ, Wong TY, Rotter JI. Challenges in elucidating the genetics of diabetic retinopathy. JAMA Ophthalmol. 2014 Jan; 132(1):96–107.

    Google Scholar 

  73. Awata T, Yamashita H, Kurihara S, Morita-Ohkubo T, Miyashita Y, et al. A genome-wide association study for diabetic retinopathy in a Japanese population: potential association with a long intergenic non-coding RNA. PLoS One. 2014;9(11):e111715. doi:10.1371/journal.pone.0111715.

    Article  PubMed  PubMed Central  Google Scholar 

  74. Sheu WH, Kuo JZ, Lee IT, Hung YJ, et al. Genome-wide association study in a Chinese population with diabetic retinopathy. Hum Mol Genet. 2013 Aug 1; 22(15):3165–73.

    Google Scholar 

  75. Burdon KP, Fogarty RD, Shen W, Abhary S, et al. Genome-wide association study for sight-threatening diabetic retinopathy reveals associationwith genetic variation near the GRB2 gene. Diabetologia. 2015;58(10):2288–97.

    Article  CAS  PubMed  Google Scholar 

  76. Grassi MA, Tikhomirov A, Ramalingam S, Below JE, Cox NJ, et al. Genome-wide meta-analysis for severe diabetic retinopathy. Hum Mol Genet. 2011;20:2472–81.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Huang YC, Lin JM, Lin HJ, Chen CC, Chen SY, et al. Genome-wide association study of diabetic retinopathy in a Taiwanese population. Ophthalmology. 2011;118:642–8.

    Article  PubMed  Google Scholar 

  78. Fu Y-P, Hallman DM, Gonzalez VH, et al. Identification of diabetic retinopathy genes through a Genome-Wide association study among Mexican-Americans from Starr County, Texas. J Ophthalmol. 2010;2010:861291. doi:10.1155/2010/861291.

    Article  PubMed  PubMed Central  Google Scholar 

  79. Jackson GR, Scott IU, Quillen DA, Walter LE, Gardner TW. Inner retinal visual dysfunction is a sensitive marker of non-proliferative diabetic retinopathy. Br J Ophthalmol. 2012;96:699–703.

    Article  PubMed  Google Scholar 

  80. Lai AK, Lo AC. Animal models of diabetic retinopathy: summary and comparison. J Diabetes Res. 2013;106594.

    Google Scholar 

  81. Robinson R, Barathi VA, Chaurasia SS, Wong TY, Kern TS. Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals. Disease Models Mechanisms. 2012;5:444–56.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  82. Jiang X, Yang L, Luo Y. Animal models of diabetic retinopathy. Curr Eye Res. 2015;40:761–71.

    Article  CAS  PubMed  Google Scholar 

  83. Hirota K, Keino H, Inoue M, Ishida H, Hirakata A. Comparisons of microRNA expression profiles in vitreous humor between eyes with macular hole and eyes with proliferative diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol. 2015;253:335–42.

    Article  CAS  PubMed  Google Scholar 

  84. Abu El-Asrar AM, De Hertogh G, Nawaz MI, et al. The tumor necrosis factor superfamily members TWEAK, TNFSF15 and fibroblast growth factor-inducible protein 14 are upregulated in proliferative diabetic retinopathy. Ophthalmic Res. 2015;53:122–30.

    Article  CAS  PubMed  Google Scholar 

  85. Nakao S. Impact of anti-VEGF therapy on the cellular microenvironment in retinal +angiogenesis. Nippon Ganka Gakkai Zasshi. 2014;118:943–52.

    PubMed  Google Scholar 

  86. Garcia de la Torre N, Fernandez-Durango R, Gomez R, et al. Expression of angiogenic microRNAs in endothelial progenitor cells from type 1 diabetic patients with and without diabetic retinopathy. Invest Ophthalmol Vis Sci. 2015;56:4090–8.

    Article  CAS  PubMed  Google Scholar 

  87. Shigeo Yoshida, Keijiro Ishikawa, Mitsuru Arima, Ryo Asato, Yukio Sassa and Tatsuro Ishibashi. Fibrovascular membranes associated with PDR: development of molecular targets by global gene expression profiling, diabetic retinopathy, Dr. Mohammad Shamsul Ola (Ed.), ISBN: 978–953–51-0044-7, InTech, 2012.

    Google Scholar 

  88. Yoshida S, Kobayashi Y, Nakama T, et al. Increased expression of M-CSF and IL-13 in vitreous of patients with proliferative diabetic retinopathy: implications for M2 macrophage-involving fibrovascular membrane formation. Br J Ophthalmol. 2015;99:629–34.

    Article  PubMed  Google Scholar 

  89. Jo HD, Cho CS, Kim JH, Jun HO, Kim JH. Animal models of diabetic retinopathy: doors to investigate pathogenesis and potential therapeutics. J Biomed Sci. 2013;20:38.

    Article  PubMed  PubMed Central  Google Scholar 

  90. Li Q, Verma A, Han PY, Nakagawa T, Johnson RJ, Grant MB, Campbell Thompson M, Jarajapu YP, Lei B, Hauswirth WW. Diabetic eNOS knockout mice develop accelerated Retinopathy. Invest Ophthalmol Vis Sci. 2010;51:5240–6.

    Article  PubMed  PubMed Central  Google Scholar 

  91. Rakoczy EP, Ali Rahman IS, Binz N, Li CR, Vagaja NN, de Pinho M, Lai CM. Characterization of a mouse model of hyperglycemia and retinal neovascularization. Am J Pathol. 2010;177:2659–70.

    Article  PubMed  PubMed Central  Google Scholar 

  92. Lee SE, Ma W, Rattigan EM, Aleshin A, Chen L, Johnson LL, D’Agati VD, Schmidt AM, Barile GR. Ultrastructural features of retinal capillary basement membrane thickening in diabetic swine. Ultrastruct Pathol. 2010;34:35–41.

    Article  PubMed  PubMed Central  Google Scholar 

  93. Gleeson M, Connaughton V, Arneson LS. Induction of hyperglycaemia in zebrafish (Danio rerio) leads to morphological changes in the retina. Acta Diabetol. 2007;44(3):157–63.

    Article  CAS  PubMed  Google Scholar 

  94. Alvarez Y, Chen K, Reynolds AL, Waghorne N, O’Connor JJ, Kennedy BN. Predominant cone photoreceptor dysfunction in a hyperglycaemic model of non-proliferative diabetic retinopathy. Dis Model Mech. 2010;3(3–4):236–45.

    Article  CAS  PubMed  Google Scholar 

  95. Tso MO, Kurosawa A, Benhamou E, Bauman A, Jeffrey J, Jonasson O. Microangiopathic retinopathy in experimental diabetic monkeys. Trans Am Ophthalmol Soc. 1988;86:389–421.

    CAS  PubMed  PubMed Central  Google Scholar 

  96. Uthra S, Raman R, Mukesh BN, Rajkumar SA, Padmaja KR, Paul PG, Lakshmipathy P, Gnanamoorthy P, Sharma T, McCarty CA, Kumaramanickavel G. Association of VEGF gene polymorphisms with diabetic retinopathy in a outh Indian cohort. Ophthalmic Genet. 2008;29(1):11–5.

    Article  CAS  PubMed  Google Scholar 

  97. Vinita K, Sripriya S, Prathiba K, Vaitheeswaran K, Sathyabaarathi R, Rajesh M, Amali J, Umashankar V, Kumaramanickavel G, Pal SS, Raman R, Sharma T. SNDREAMS project. ICAM-1 K469E polymorphism is a genetic determinant for the clinical risk factors of T2D subjects with retinopathy in Indians: A population-based case-control study. BMJ Open. 2012;2(4)

    Google Scholar 

  98. Sobrin L, Green T, Sim X, Jensen RA, et al. Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: The Candidate gene Association Resource (CARe). Invest Ophthalmol Vis Sci. 2011;52(10):7593–602.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  99. Hallman DM, Boerwinkle E, Gonzalez VH, Klein BE, Klein R, CLA H. Genome-wide linkage scan for diabetic retinopathy susceptibility genes in Mexican Americans with type 2 diabetes from Starr County, Texas. Diabetes. 2007;56(4):1167–73.

    Article  CAS  PubMed  Google Scholar 

  100. Imperatore G, Hanson RL, Pettitt DJ, Kobes S, Bennett PH, Knowler WC. Sib-pair linkage analysis for susceptibility genes for microvascular complications among Pima Indians with type 2 diabetes. Pima diabetes genes group. Diabetes. 1998;47(5):821–30.

    Article  CAS  PubMed  Google Scholar 

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Sripriya, S., Raman, R., Soumittra, N., Pandian, A.J. (2017). Current Research Perspectives in Understanding Diabetic Retinopathy. In: Prakash, G., Iwata, T. (eds) Advances in Vision Research, Volume I. Essentials in Ophthalmology. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56511-6_19

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