Abstract
It is becoming increasingly clear that inhalation exposure to particulate matter (PM) can lead to or exacerbate various diseases, which are not limited to the lung but extend to the cardiovascular system and possibly other organs and tissues. Epidemiological studies have provided strong evidence for associations with chronic obstructive pulmonary disease (COPD), asthma, bronchitis and cardiovascular disease, while the evidence for a link with lung cancer is less strong. Novel research has provided first hints that exposure to PM might lead to diabetes and central nervous system (CNS) pathology. In the current review, an overview is presented of the toxicological basis for adverse health effects that have been linked to PM inhalation. Oxidative stress and inflammation are discussed as central processes driving adverse effects; in addition, profibrotic and allergic processes are implicated in PM-related diseases. Effects of PM on key cell types considered as regulators of inflammatory, fibrotic and allergic mechanisms are described.
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References
Bowman DM, Balch JK, Artaxo P, Bond WJ, Carlson JM, Cochrane MA, D’Antonio CM, Defries RS, Doyle JC, Harrison SP, Johnston FH, Keeley JE, Krawchuk MA, Kull CA, Marston JB, Moritz MA, Prentice IC, Roos CI, Scott AC, Swetnam TW, van der Werf GR, Pyne SJ (2009) Fire in the Earth system. Science 324:481–484
Nemery B, Hoet PH, Nemmar A (2001) The Meuse Valley fog of 1930: an air pollution disaster. Lancet 357:704–708
Firket J (1936) Fog along the Meuse Valley. Trans Faraday Soc 32:1192–1197
London Ministry of Health (1954) Mortality and morbidity during the London Fog of December 1952. Reports on Public Health and Medical Subjects no 95, London
Dooley EE (2002) Fifty years later: clearing the air over the London smog. Environ Health Perspect 110:A748
Bown W (1994) Dying from too much dust. New Scientist 12:12–13
Pope CA 3rd (1989) Respiratory disease associated with community air pollution and a steel mill, Utah Valley. Am J Public Health 79:623–628
Ghio AJ (2004) Biological effects of Utah Valley ambient air particles in humans: a review. J Aerosol Med 17:157–164
Daniels MJ, Dominici F, Samet JM, Zeger SL (2000) Estimating particulate matter-mortality dose-response curves and threshold levels: an analysis of daily time-series for the 20 largest US cities. Am J Epidemiol 152:397–406
Dockery DW, Pope CA 3rd, Xu X, Spengler JD, Ware JH, Fay ME, Ferris BG Jr, Speizer FE (1993) An association between air pollution and mortality in six U.S. cities. N Engl J Med 329:1753–1759
Pope CA 3rd, Burnett RT, Thun MJ, Calle EE, Krewski D, Ito K, Thurston GD (2002) Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. J Am Med Assoc 287:1132–1141
Clancy L, Goodman P, Sinclair H, Dockery DW (2002) Effect of air-pollution control on death rates in Dublin, Ireland: an intervention study. Lancet 360:1210–1214
Schins RP, Lightbody JH, Borm PJ, Shi T, Donaldson K, Stone V (2004) Inflammatory effects of coarse and fine particulate matter in relation to chemical and biological constituents. Toxicol Appl Pharmacol 195:1–11
Turnbull AB, Harrison RM (2000) Major component contributions to PM10 composition in the UK atmosphere. Atmos Environ 34:3129–3137
Lippmann M (2000) Environmental toxicants. Wiley, New York, NY
Oberdörster G, Oberdörster E, Oberdörster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823–839
Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, Wang M, Oberley T, Froines J, Nel A (2003) Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect 111:455–460
Scheepers PT, Bos RP (1992) Combustion of diesel fuel from a toxicological perspective I. Origin of incomplete combustion products. Int Arch Occup Environ Health 64:149–161
Saldiva PH, Clarke RW, Coull BA, Stearns RC, Lawrence J, Murthy GG, Diaz E, Koutrakis P, Suh H, Tsuda A, Godleski JJ (2002) Lung inflammation induced by concentrated ambient air particles is related to particle composition. Am J Respir Crit Care Med 165:1610–1617
WHO (2006) Air quality guidelines for particulate matter, ozone, nitrogen dioxide and sulfur dioxide—summary of risk assessment. World Health Organization, Geneva, Switzerland. Online available at http://www.who.int/phe/health_topics/outdoorair_aqg/en/
Kreyling WG, Möller W, Semmler-Behnke M, Oberdörster G (2007) Particle dosimetry: deposition and clearance from the respiratory tract and translocation towards extra-pulmonary sites. In: Donaldson K, Borm P (eds) Particle toxicology. CRC, Taylor & Francis, Boca Raton, FL, pp 47–74
Wei F, Teng E, Wu G, Hu W, Wilson WE, Chapman RS, Pau PC, Zahang J (1999) Ambient concentrations and elemental compositions of PM10 and PM2.5 in four Chinese cities. Environ Sci Technol 33:4188–4193
Pope CA 3rd (2000) Epidemiology of fine particulate air pollution and human health: biologic mechanisms and who’s at risk? Environ Health Perspect 108(Suppl 4):713–723
Hathout EH, Beeson WL, Nahab F, Rabadi A, Thomas W, Mace JW (2002) Role of exposure to air pollutants in the development of type 1 diabetes before and after 5 year of age. Pediatr Diab 3:184–188
Pearson JF, Bachireddy C, Shyamprasad S, Goldfine AB, Brownstein JS (2010) Association between fine particulate matter and diabetes prevalence in the U.S. Diabetes Care 33:2196–2201
Krämer U, Herder C, Sugiri D, Strassburger K, Schikowski T, Ranft U, Rathmann W (2010) Traffic-related air pollution and incident type 2 diabetes: results from the SALIA cohort study. Environ Health Perspect 118:1273–1279
UNEP (1994) U.N. Environment Programme and WHO report. Environment 36:4
Aust AE, Ball JC, Hu AA, Lighty JS, Smith KR, Straccia AM, Veranth JM, Young WC (2002) Particle characteristics responsible for effects on human lung epithelial cells. Res Rep Health Eff Inst 110:1–65 (discussion 67–76)
Ghio AJ, Devlin RB (2001) Inflammatory lung injury after bronchial instillation of air pollution particles. Am J Respir Crit Care Med 164:704–708
Molinelli AR, Madden MC, McGee JK, Stonehuerner JG, Ghio AJ (2002) Effect of metal removal on the toxicity of airborne particulate matter from the Utah Valley. Inhal Toxicol 14:1069–1086
Donaldson K, Stone V, Borm PJ, Jimenez LA, Gilmour PS, Schins RP, Knaapen AM, Rahman I, Faux SP, Brown DM, MacNee W (2003) Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10). Free Radic Biol Med 34:1369–1382
Seaton A, MacNee W, Donaldson K, Godden D (1995) Particulate air pollution and acute health effects. Lancet 345:176–178
Monn C, Becker S (1999) Cytotoxicity and induction of proinflammatory cytokines from human monocytes exposed to fine (PM2.5) and coarse particles (PM10-2.5) in outdoor and indoor air. Toxicol Appl Pharmacol 155:245–252
Bonvallot V, Baeza-Squiban A, Baulig A, Brulant S, Boland S, Muzeau F, Barouki R, Marano F (2001) Organic compounds from diesel exhaust particles elicit a proinflammatory response in human airway epithelial cells and induce cytochrome p450 1A1 expression. Am J Respir Cell Mol Biol 25:515–521
Nel AE, Diaz-Sanchez D, Li N (2001) The role of particulate pollutants in pulmonary inflammation and asthma: evidence for the involvement of organic chemicals and oxidative stress. Curr Opin Pulm Med 7:20–26
Donaldson K, Tran CL (2002) Inflammation caused by particles and fibers. Inhal Toxicol 14:5–27
Lee JT, Son JY, Cho YS (2007) The adverse effects of fine particle air pollution on respiratory function in the elderly. Sci Total Environ 385:28–36
Zanobetti A, Schwartz J (2001) Are diabetics more susceptible to the health effects of airborne particles? Am J Respir Crit Care Med 164:831–833
Yang IA, Fong KM, Zimmerman PV, Holgate ST, Holloway JW (2008) Genetic susceptibility to the respiratory effects of air pollution. Thorax 63:555–563
Nel AE, Diaz-Sanchez D, Ng D, Hiura T, Saxon A (1998) Enhancement of allergic inflammation by the interaction between diesel exhaust particles and the immune system. J Allergy Clin Immunol 102:539–554
Samet JM, Dominici F, Curriero FC, Coursac I, Zeger SL (2000) Fine particulate air pollution and mortality in 20 U.S. cities, 1987-1994. N Engl J Med 343:1742–1749
MacNee W, Donaldson K (2000) Exacerbations of COPD: environmental mechanisms. Chest 117:390S–397S
Sint T, Donohue JF, Ghio AJ (2008) Ambient air pollution particles and the acute exacerbation of chronic obstructive pulmonary disease. Inhal Toxicol 20:25–29
Wordley J, Walters S, Ayres JG (1997) Short term variations in hospital admissions and mortality and particulate air pollution. Occup Environ Med 54:108–116
Churg A, Brauer M, del Carmen Avila-Casado M, Fortoul TI, Wright JL (2003) Chronic exposure to high levels of particulate air pollution and small airway remodeling. Environ Health Perspect 111:714–718
Bonner JC (2007) Lung fibrotic responses to particle exposure. Toxicol Pathol 35:148–153
Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA (2006) Transforming growth factor-β regulation of immune responses. Annu Rev Immunol 24:99–146
Vanhee D, Gosset P, Wallaert B, Voisin C, Tonnel AB (1994) Mechanisms of fibrosis in coal workers’ pneumoconiosis. Increased production of platelet-derived growth factor, insulin-like growth factor type I, and transforming growth factor beta and relationship to disease severity. Am J Respir Crit Care Med 150:1049–1055
Yamashita N, Sekine K, Miyasaka T, Kawashima R, Nakajima Y, Nakano J, Yamamoto T, Horiuchi T, Hirai K, Ohta K (2001) Platelet-derived growth factor is involved in the augmentation of airway responsiveness through remodeling of airways in diesel exhaust particulate-treated mice. J Allergy Clin Immunol 107:135–142
Zhang K, Phan SH (1996) Cytokines and pulmonary fibrosis. Biol Signals 5:232–239
Wynn TA (2008) Cellular and molecular mechanisms of fibrosis. J Pathol 214:199–210
Hunninghake GW, Garrett KC, Richerson HB, Fantone JC, Ward PA, Rennard SI, Bitterman PB, Crystal RG (1984) Pathogenesis of the granulomatous lung diseases. Am Rev Respir Dis 130:476–496
von Klot S, Wolke G, Tuch T, Heinrich J, Dockery DW, Schwartz J, Kreyling WG, Wichmann HE, Peters A (2002) Increased asthma medication use in association with ambient fine and ultrafine particles. Eur Respir J 20:691–702
de Haar C, Hassing I, Bol M, Bleumink R, Pieters R (2006) Ultrafine but not fine particulate matter causes airway inflammation and allergic airway sensitization to co-administered antigen in mice. Clin Exp Allergy 36:1469–1479
Kleinman MT, Sioutas C, Froines JR, Fanning E, Hamade A, Mendez L, Meacher D, Oldham M (2007) Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice. Inhal Toxicol 19(Suppl 1):117–126
de Haar C, Kool M, Hassing I, Bol M, Lambrecht BN, Pieters R (2008) Lung dendritic cells are stimulated by ultrafine particles and play a key role in particle adjuvant activity. J Allergy Clin Immunol 121:1246–1254
Inoue K, Koike E, Takano H, Yanagisawa R, Ichinose T, Yoshikawa T (2009) Effects of diesel exhaust particles on antigen-presenting cells and antigen-specific Th immunity in mice. Exp Biol Med 234:200–209
Provoost S, Maes T, Willart MA, Joos GF, Lambrecht BN, Tournoy KG (2010) Diesel exhaust particles stimulate adaptive immunity by acting on pulmonary dendritic cells. J Immunol 184:426–432
Laden F, Schwartz J, Speizer FE, Dockery DW (2006) Reduction in fine particulate air pollution and mortality: extended follow-up of the Harvard Six Cities study. Am J Respir Crit Care Med 173:667–672
Mauderly JL (2000) Diesel exhaust. In: Lippmann M (ed) Environmental toxicants: human exposure and their health effects. Wiley, New York, NY
Schins RP (2002) Mechanisms of genotoxicity of particles and fibers. Inhal Toxicol 14:57–78
Azad N, Rojanasakul Y, Vallyathan V (2008) Inflammation and lung cancer: roles of reactive oxygen/nitrogen species. J Toxicol Environ Health B Crit Rev 11:1–15
Knaapen AM, Borm PJ, Albrecht C, Schins RP (2004) Inhaled particles and lung cancer part A: mechanisms. Int J Cancer 109:799–809
Castranova V, Ma JY, Yang HM, Antonini JM, Butterworth L, Barger MW, Roberts J, Ma JK (2001) Effect of exposure to diesel exhaust particles on the susceptibility of the lung to infection. Environ Health Perspect 109(Suppl 4):609–612
Yang HM, Antonini JM, Barger MW, Butterworth L, Roberts BR, Ma JK, Castranova V, Ma JY (2001) Diesel exhaust particles suppress macrophage function and slow the pulmonary clearance of Listeria monocytogenes in rats. Environ Health Perspect 109:515–521
Becker S, Soukup JM (1999) Exposure to urban air particulates alters the macrophage-mediated inflammatory response to respiratory viral infection. J Toxicol Environ Health A 57:445–457
Mills NL, Donaldson K, Hadoke PW, Boon NA, MacNee W, Cassee FR, Sandström T, Blomberg A, Newby DE (2009) Adverse cardiovascular effects of air pollution. Nat Clin Pract Cardiovasc Med 6:36–44
Brook RD (2008) Cardiovascular effects of air pollution. Clin Sci 115:175–187
Brook RD, Franklin B, Cascio W, Hong Y, Howard G, Lipsett M, Luepker R, Mittleman M, Samet J, Smith SC Jr, Trager I (2004) Air pollution and cardiovascular disease: a statement for healthcare professionals from the expert panel on population and prevention science of the American Heart Association. Circulation 109:2655–2671
Brook RD, Rajagopalan S, Pope CA 3rd, Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F, Hong Y, Luepker RV, Mittleman MA, Peters A, Siscovick D, Smith SC Jr, Whitsel L, Kaufman JD (2010) Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association. Circulation 121:2331–2378
Simkhovich BZ, Kleinman MT, Kloner RA (2009) Particulate air pollution and coronary heart disease. Curr Opin Cardiol 24:604–609
O’Toole TE, Hellmann J, Wheat L, Haberzettl P, Lee J, Conklin DJ, Bhatnagar A, Pope CA 3rd (2010) Episodic exposure to fine particulate air pollution decreases circulating levels of endothelial progenitor cells. Circ Res 107:200–203
Ruckerl R, Phipps RP, Schneider A, Frampton M, Cyrys J, Oberdörster G, Wichmann HE, Peters A (2007) Ultrafine particles and platelet activation in patients with coronary heart disease—results from a prospective panel study. Part Fibre Toxicol 4:1
Rundell KW, Hoffman JR, Caviston R, Bulbulian R, Hollenbach AM (2007) Inhalation of ultrafine and fine particulate matter disrupts systemic vascular function. Inhal Toxicol 19:133–140
Briet M, Collin C, Laurent S, Tan A, Azizi M, Agharazii M, Jeunemaitre X, Alhenc-Gelas F, Boutouyrie P (2007) Endothelial function and chronic exposure to air pollution in normal male subjects. Hypertension 50:970–976
Kunzli N, Jerrett M, Mack WJ, Beckerman B, LaBree L, Gilliland F, Thomas D, Peters J, Hodis HN (2005) Ambient air pollution and atherosclerosis in Los Angeles. Environ Health Perspect 113:201–206
Mills NL, Törnqvist H, Gonzalez MC, Vink E, Robinson SD, Söderberg S, Boon NA, Donaldson K, Sandström T, Blomberg A, Newby DE (2007) Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease. N Engl J Med 357:1075–1082
Mills NL, Törnqvist H, Robinson SD, Gonzalez M, Darnley K, MacNee W, Boon NA, Donaldson K, Blomberg A, Sandström T, Newby DE (2005) Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation 112:3930–3936
Dubowsky SD, Suh H, Schwartz J, Coull BA, Gold DR (2006) Diabetes, obesity, and hypertension may enhance associations between air pollution and markers of systemic inflammation. Environ Health Perspect 114:992–998
Schneider A, Neas LM, Graff DW, Herbst MC, Cascio WE, Schmitt MT, Buse JB, Peters A, Devlin RB (2010) Association of cardiac and vascular changes with ambient PM2.5 in diabetic individuals. Part Fibre Toxicol 7:14
O’Neill MS, Veves A, Sarnat JA, Zanobetti A, Gold DR, Economides PA, Horton ES, Schwartz J (2007) Air pollution and inflammation in type 2 diabetes: a mechanism for susceptibility. Occup Environ Med 64:373–379
Liu L, Ruddy TD, Dalipaj M, Szyszkowicz M, You H, Poon R, Wheeler A, Dales R (2007) Influence of personal exposure to particulate air pollution on cardiovascular physiology and biomarkers of inflammation and oxidative stress in subjects with diabetes. J Occup Environ Med 49:258–265
Jacobs L, Emmerechts J, Mathieu C, Hoylaerts MF, Fierens F, Hoet PH, Nemery B, Nawrot TS (2010) Air pollution related prothrombotic changes in persons with diabetes. Environ Health Perspect 118:191–196
LeBlanc AJ, Cumpston JL, Chen BT, Frazer D, Castranova V, Nurkiewicz TR (2009) Nanoparticle inhalation impairs endothelium-dependent vasodilation in subepicardial arterioles. J Toxicol Environ Health A 72:1576–1584
Nurkiewicz TR, Porter DW, Barger M, Castranova V, Boegehold MA (2004) Particulate matter exposure impairs systemic microvascular endothelium-dependent dilation. Environ Health Perspect 112:1299–1306
Nurkiewicz TR, Porter DW, Barger M, Millecchia L, Rao KM, Marvar PJ, Hubbs AF, Castranova V, Boegehold MA (2006) Systemic microvascular dysfunction and inflammation after pulmonary particulate matter exposure. Environ Health Perspect 114:412–419
Tamagawa E, Bai N, Morimoto K, Gray C, Mui T, Yatera K, Zhang X, Xing L, Li Y, Laher I, Sin DD, Man SF, van Eeden SF (2008) Particulate matter exposure induces persistent lung inflammation and endothelial dysfunction. Am J Physiol Lung Cell Mol Physiol 295:L79–L85
Nemmar A, Hoet PH, Dinsdale D, Vermylen J, Hoylaerts MF, Nemery B (2003) Diesel exhaust particles in lung acutely enhance experimental peripheral thrombosis. Circulation 107:1202–1208
Nemmar A, Nemery B, Hoet PH, Vermylen J, Hoylaerts MF (2003) Pulmonary inflammation and thrombogenicity caused by diesel particles in hamsters: role of histamine. Am J Respir Crit Care Med 168:1366–1372
Nemmar A, Al-Salam S, Dhanasekaran S, Sudhadevi M, Ali BH (2009) Pulmonary exposure to diesel exhaust particles promotes cerebral microvessel thrombosis: protective effect of a cysteine prodrug L-2-oxothiazolidine-4-carboxylic acid. Toxicology 263:84–92
Yokota S, Seki T, Naito Y, Tachibana S, Hirabayashi N, Nakasaka T, Ohara N, Kobayashi H (2008) Tracheal instillation of diesel exhaust particles component causes blood and pulmonary neutrophilia and enhances myocardial oxidative stress in mice. J Toxicol Sci 33:609–620
Cascio WE, Cozzi E, Hazarika S, Devlin RB, Henriksen RA, Lust RM, Van Scott MR, Wingard CJ (2007) Cardiac and vascular changes in mice after exposure to ultrafine particulate matter. Inhal Toxicol 19(Suppl 1):67–73
Nurkiewicz TR, Porter DW, Hubbs AF, Cumpston JL, Chen BT, Frazer DG, Castranova V (2008) Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction. Part Fibre Toxicol 5:1
Quan C, Sun Q, Lippmann M, Chen LC (2010) Comparative effects of inhaled diesel exhaust and ambient fine particles on inflammation, atherosclerosis, and vascular dysfunction. Inhal Toxicol 22:738–753
Hansen CS, Sheykhzade M, Møller P, Folkmann JK, Amtorp O, Jonassen T, Loft S (2007) Diesel exhaust particles induce endothelial dysfunction in apoE–/– mice. Toxicol Appl Pharmacol 219:24–32
Chen LC, Nadziejko C (2005) Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice V. CAPs exacerbate aortic plaque development in hyperlipidemic mice. Inhal Toxicol 17:217–224
Sun Q, Wang A, Jin X, Natanzon A, Duquaine D, Brook RD, Aguinaldo JG, Fayad ZA, Fuster V, Lippmann M, Chen LC, Rajagopalan S (2005) Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model. J Am Med Assoc 294:3003–3010
Ying Z, Kampfrath T, Thurston G, Farrar B, Lippmann M, Wang A, Sun Q, Chen LC, Rajagopalan S (2009) Ambient particulates alter vascular function through induction of reactive oxygen and nitrogen species. Toxicol Sci 111:80–88
Goto Y, Hogg JC, Shih CH, Ishii H, Vincent R, van Eeden SF (2004) Exposure to ambient particles accelerates monocyte release from bone marrow in atherosclerotic rabbits. Am J Physiol Lung Cell Mol Physiol 287:L79–L85
Yatera K, Hsieh J, Hogg JC, Tranfield E, Suzuki H, Shih CH, Behzad AR, Vincent R, van Eeden SF (2008) Particulate matter air pollution exposure promotes recruitment of monocytes into atherosclerotic plaques. Am J Physiol Heart Circ Physiol 294:H944–H953
Lei YC, Chen MC, Chan CC, Wang PY, Lee CT, Cheng TJ (2004) Effects of concentrated ambient particles on airway responsiveness and pulmonary inflammation in pulmonary hypertensive rats. Inhal Toxicol 16:785–792
Kodavanti UP, Schladweiler MC, Ledbetter AD, Hauser R, Christiani DC, McGee J, Richards JR, Costa DL (2002) Temporal association between pulmonary and systemic effects of particulate matter in healthy and cardiovascular compromised rats. J Toxicol Environ Health A 65:1545–1569
Ulrich MM, Alink GM, Kumarathasan P, Vincent R, Boere AJ, Cassee FR (2002) Health effects and time course of particulate matter on the cardiopulmonary system in rats with lung inflammation. J Toxicol Environ Health A 65:1571–1595
Nemmar A, Vanbilloen H, Hoylaerts MF, Hoet PH, Verbruggen A, Nemery B (2001) Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster. Am J Respir Crit Care Med 164:1665–1668
Nemmar A, Hoet PH, Vanquickenborne B, Dinsdale D, Thomeer M, Hoylaerts MF, Vanbilloen H, Mortelmans L, Nemery B (2002) Passage of inhaled particles into the blood circulation in humans. Circulation 105:411–414
Kreyling WG, Semmler-Behnke M, Seitz J, Scymczak W, Wenk A, Mayer P, Takenaka S, Oberdörster G (2009) Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs. Inhal Toxicol 21(Suppl 1):55–60
Semmler-Behnke M, Kreyling WG, Lipka J, Fertsch S, Wenk A, Takenaka S, Schmid G, Brandau W (2008) Biodistribution of 1.4- and 18-nm gold particles in rats. Small 4:2108–2111
Takenaka S, Karg E, Kreyling WG, Lentner B, Möller W, Behnke-Semmler M, Jennen L, Walch A, Michalke B, Schramel P, Heyder J, Schulz H (2006) Distribution pattern of inhaled ultrafine gold particles in the rat lung. Inhal Toxicol 18:733–740
Mills NL, Amin N, Robinson SD, Anand A, Davies J, Patel D, de la Fuente JM, Cassee FR, Boon NA, Macnee W, Millar AM, Donaldson K, Newby DE (2006) Do inhaled carbon nanoparticles translocate directly into the circulation in humans? Am J Respir Crit Care Med 173:426–431
Möller W, Felten K, Sommerer K, Scheuch G, Meyer G, Meyer P, Haussinger K, Kreyling WG (2008) Deposition, retention, and translocation of ultrafine particles from the central airways and lung periphery. Am J Respir Crit Care Med 177:426–432
Wiebert P, Sanchez-Crespo A, Seitz J, Falk R, Philipson K, Kreyling WG, Möller W, Sommerer K, Larsson S, Svartengren M (2006) Negligible clearance of ultrafine particles retained in healthy and affected human lungs. Eur Respir J 28:286–290
Donaldson K, Tran L, Jimenez LA, Duffin R, Newby DE, Mills N, MacNee W, Stone V (2005) Combustion-derived nanoparticles: a review of their toxicology following inhalation exposure. Part Fibre Toxicol 2:10
Clayton TC, Thompson M, Meade TW (2008) Recent respiratory infection and risk of cardiovascular disease: case-control study through a general practice database. Eur Heart J 29:96–103
Ghio AJ, Kim C, Devlin RB (2000) Concentrated ambient air particles induce mild pulmonary inflammation in healthy human volunteers. Am J Respir Crit Care Med 162:981–988
Gong H Jr, Linn WS, Sioutas C, Terrell SL, Clark KW, Anderson KR, Terrell LL (2003) Controlled exposures of healthy and asthmatic volunteers to concentrated ambient fine particles in Los Angeles. Inhal Toxicol 15:305–325
Rivero DH, Soares SR, Lorenzi-Filho G, Saiki M, Godleski JJ, Antonangelo L, Dolhnikoff M, Saldiva PH (2005) Acute cardiopulmonary alterations induced by fine particulate matter of Sao Paulo, Brazil. Toxicol Sci 85:898–905
Rückerl R, Ibald-Mulli A, Koenig W, Schneider A, Woelke G, Cyrys J, Heinrich J, Marder V, Frampton M, Wichmann HE, Peters A (2006) Air pollution and markers of inflammation and coagulation in patients with coronary heart disease. Am J Respir Crit Care Med 173:432–441
Schwartz J (2001) Air pollution and blood markers of cardiovascular risk. Environ Health Perspect 109(Suppl 3):405–409
Oikonen M, Laaksonen M, Laippala P, Oksaranta O, Lilius EM, Lindgren S, Rantio-Lehtimaki A, Anttinen A, Koski K, Eralinna JP (2003) Ambient air quality and occurrence of multiple sclerosis relapse. Neuroepidemiology 22:95–99
Calderon-Garciduenas L, Reed W, Maronpot RR, Henriquez-Roldan C, Delgado-Chavez R, Calderon-Garciduenas A, Dragustinovis I, Franco-Lira M, Aragon-Flores M, Solt AC, Altenburg M, Torres-Jardon R, Swenberg JA (2004) Brain inflammation and Alzheimer’s-like pathology in individuals exposed to severe air pollution. Toxicol Pathol 32:650–658
Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, Cox C (2004) Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol 16:437–445
Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Ito Y, Finkelstein J, Oberdörster G (2006) Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ Health Perspect 114:1172–1178
Cruts B, van Etten L, Törnqvist H, Blomberg A, Sandström T, Mills NL, Borm PJ (2008) Exposure to diesel exhaust induces changes in EEG in human volunteers. Part Fibre Toxicol 5:4
Ranft U, Schikowski T, Sugiri D, Krutmann J, Kramer U (2009) Long-term exposure to traffic-related particulate matter impairs cognitive function in the elderly. Environ Res 109:1004–1011
Suglia SF, Gryparis A, Wright RO, Schwartz J, Wright RJ (2008) Association of black carbon with cognition among children in a prospective birth cohort study. Am J Epidemiol 167:280–286
Calderon-Garciduenas L, Mora-Tiscareno A, Ontiveros E, Gomez-Garza G, Barragan-Mejia G, Broadway J, Chapman S, Valencia-Salazar G, Jewells V, Maronpot RR, Henriquez-Roldan C, Perez-Guille B, Torres-Jardon R, Herrit L, Brooks D, Osnaya-Brizuela N, Monroy ME, Gonzalez-Maciel A, Reynoso-Robles R, Villarreal-Calderon R, Solt AC, Engle RW (2008) Air pollution, cognitive deficits and brain abnormalities: a pilot study with children and dogs. Brain Cogn 68:117–127
Campbell A, Oldham M, Becaria A, Bondy SC, Meacher D, Sioutas C, Misra C, Mendez LB, Kleinman M (2005) Particulate matter in polluted air may increase biomarkers of inflammation in mouse brain. Neurotoxicology 26:133–140
Kleinman MT, Araujo JA, Nel A, Sioutas C, Campbell A, Cong PQ, Li H, Bondy SC (2008) Inhaled ultrafine particulate matter affects CNS inflammatory processes and may act via MAP kinase signaling pathways. Toxicol Lett 178:127–130
Veronesi B, Makwana O, Pooler M, Chen LC (2005) Effects of subchronic exposures to concentrated ambient particles. VII. Degeneration of dopaminergic neurons in Apo E–/– mice. Inhal Toxicol 17:235–241
Sirivelu MP, MohanKumar SM, Wagner JG, Harkema JR, MohanKumar PS (2006) Activation of the stress axis and neurochemical alterations in specific brain areas by concentrated ambient particle exposure with concomitant allergic airway disease. Environ Health Perspect 114:870–874
Gerlofs-Nijland ME, van Berlo D, Cassee FR, Schins RP, Wang K, Campbell A (2010) Effect of prolonged exposure to diesel engine exhaust on proinflammatory markers in different regions of the rat brain. Part Fibre Toxicol 7:12
van Berlo D, Albrecht C, Knaapen AM, Cassee FR, Gerlofs-Nijland ME, Kooter IM, Palomero-Gallagher N, Bidmon HJ, van Schooten FJ, Krutmann J, Schins RP (2010) Comparative evaluation of the effects of short-term inhalation exposure to diesel engine exhaust on rat lung and brain. Arch Toxicol 84:553–562
Suzuki T, Oshio S, Iwata M, Saburi H, Odagiri T, Udagawa T, Sugawara I, Umezawa M, Takeda K (2010) In utero exposure to a low concentration of diesel exhaust affects spontaneous locomotor activity and monoaminergic system in male mice. Part Fibre Toxicol 7:7
Qin L, Wu X, Block ML, Liu Y, Breese GR, Hong JS, Knapp DJ, Crews FT (2007) Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 55:453–462
Rivest S (2001) How circulating cytokines trigger the neural circuits that control the hypothalamic-pituitary-adrenal axis. Psychoneuroendocrinology 26:761–788
Lim HB, Ichinose T, Miyabara Y, Takano H, Kumagai Y, Shimojyo N, Devalia JL, Sagai M (1998) Involvement of superoxide and nitric oxide on airway inflammation and hyperresponsiveness induced by diesel exhaust particles in mice. Free Radic Biol Med 25:635–644
Gurgueira SA, Lawrence J, Coull B, Murthy GG, Gonzalez-Flecha B (2002) Rapid increases in the steady-state concentration of reactive oxygen species in the lungs and heart after particulate air pollution inhalation. Environ Health Perspect 110:749–755
Li N, Xia T, Nel AE (2008) The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles. Free Radic Biol Med 44:1689–1699
Xiao GG, Wang M, Li N, Loo JA, Nel AE (2003) Use of proteomics to demonstrate a hierarchical oxidative stress response to diesel exhaust particle chemicals in a macrophage cell line. J Biol Chem 278:50781–50790
Donaldson K, MacNee W (1998) The mechanism of lung injury by PM10. In: Hester RE, Harrison RM (eds) Air pollution and health. The Royal Society of Chemistry, pp 21–32. Online available at http://www.knovel.com/web/portal/browse/display?_EXT_KNOVEL_DISPLAY_bookid=644
Sies H (1985) Oxidative stress: introductory remarks. In: Sies H (ed) Oxidative stress. Academic, London, pp 1–8
Knaapen AM, Shi T, Borm PJ, Schins RP (2002) Soluble metals as well as the insoluble particle fraction are involved in cellular DNA damage induced by particulate matter. Mol Cell Biochem 234–235:317–326
Shi T, Knaapen AM, Begerow J, Birmili W, Borm PJ, Schins RP (2003) Temporal variation of hydroxyl radical generation and 8-hydroxy-2′-deoxyguanosine formation by coarse and fine particulate matter. Occup Environ Med 60:315–321
Shi T, Duffin R, Borm PJ, Li H, Weishaupt C, Schins RP (2006) Hydroxyl-radical-dependent DNA damage by ambient particulate matter from contrasting sampling locations. Environ Res 101:18–24
Schaumann F, Borm PJ, Herbrich A, Knoch J, Pitz M, Schins RP, Luettig B, Hohlfeld JM, Heinrich J, Krug N (2004) Metal-rich ambient particles (particulate matter 2.5) cause airway inflammation in healthy subjects. Am J Respir Crit Care Med 170:898–903
Baulig A, Poirault JJ, Ausset P, Schins R, Shi T, Baralle D, Dorlhene P, Meyer M, Lefevre R, Baeza-Squiban A, Marano F (2004) Physicochemical characteristics and biological activities of seasonal atmospheric particulate matter sampling in two locations of Paris. Environ Sci Technol 38:5985–5992
Brown DM, Wilson MR, MacNee W, Stone V, Donaldson K (2001) Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol Appl Pharmacol 175:191–199
Wessels A, Van Berlo D, Boots AW, Gerloff K, Scherbart A, Cassee FR, Gerlofs-Nijland ME, Van Schooten FJ, Albrecht C, Schins RP (2011) Oxidative stress and DNA damage responses in rat and mouse lung to inhaled carbon nanoparticles. Nanotoxicology 5:66–78
Donaldson K, Brown DM, Mitchell C, Dineva M, Beswick PH, Gilmour P, MacNee W (1997) Free radical activity of PM10: iron-mediated generation of hydroxyl radicals. Environ Health Perspect 105(Suppl 5):1285–1289
Squadrito GL, Cueto R, Dellinger B, Pryor WA (2001) Quinoid redox cycling as a mechanism for sustained free radical generation by inhaled airborne particulate matter. Free Radic Biol Med 31:1132–1138
Baulig A, Sourdeval M, Meyer M, Marano F, Baeza-Squiban A (2003) Biological effects of atmospheric particles on human bronchial epithelial cells. Comparison with diesel exhaust particles. Toxicol In Vitro 17:567–573
Ades EW, Candal FJ, Swerlick RA, George VG, Summers S, Bosse DC, Lawley TJ (1992) HMEC-1: establishment of an immortalized human microvascular endothelial cell line. J Invest Dermatol 99:683–690
Penning TM, Burczynski ME, Hung CF, McCoull KD, Palackal NT, Tsuruda LS (1999) Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: generation of reactive and redox active o-quinones. Chem Res Toxicol 12:1–18
DosReis GA, Borges VM (2003) Role of Fas-ligand induced apoptosis in pulmonary inflammation and injury. Curr Drug Targets Inflamm Allergy 2:161–167
Shepherd VL (1986) The role of the respiratory burst of phagocytes in host defense. Semin Respir Infect 1:99–106
Segal AW (2005) How neutrophils kill microbes. Ann Rev Immunol 23:197–223
Emmendoerffer A, Hecht M, Boeker T, Mueller M, Heinrich U (2000) Role of inflammation in chemical-induced lung cancer. Toxicol Lett 112–113:185–191
Hancock JT, Desikan R, Neill SJ (2001) Role of reactive oxygen species in cell signalling pathways. Biochem Soc Trans 29:345–350
Shacter E, Weitzman SA (2002) Chronic inflammation and cancer. Oncology 16(217–226):229(discussion 230–212)
Knaapen AM, Gungor N, Schins RP, Borm PJ, Van Schooten FJ (2006) Neutrophils and respiratory tract DNA damage and mutagenesis: a review. Mutagenesis 21:225–236
Sips HJ, Hamers MN (1981) Mechanism of the bactericidal action of myeloperoxidase: increased permeability of the Escherichia coli cell envelope. Infect Immun 31:11–16
Guo FH, De Raeve HR, Rice TW, Stuehr DJ, Thunnissen FB, Erzurum SC (1995) Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo. Proc Natl Acad Sci USA 92:7809–7813
Robbins RA, Barnes PJ, Springall DR, Warren JB, Kwon OJ, Buttery LD, Wilson AJ, Geller DA, Polak JM (1994) Expression of inducible nitric oxide in human lung epithelial cells. Biochem Biophys Res Commun 203:209–218
Taniyama Y, Griendling KK (2003) Reactive oxygen species in the vasculature: molecular and cellular mechanisms. Hypertension 42:1075–1081
Wu LL, Chiou CC, Chang PY, Wu JT (2004) Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics. Clin Chim Acta 339:1–9
Marnett LJ (2000) Oxyradicals and DNA damage. Carcinogenesis 21:361–370
Schins RP, Knaapen AM (2007) Genotoxicity of poorly soluble particles. Inhal Toxicol 19(Suppl 1):189–198
Schraufstatter I, Hyslop PA, Jackson JH, Cochrane CG (1988) Oxidant-induced DNA damage of target cells. J Clin Invest 82:1040–1050
Chong YC, Heppner GH, Paul LA, Fulton AM (1989) Macrophage-mediated induction of DNA strand breaks in target tumor cells. Cancer Res 49:6652–6657
Driscoll KE, Deyo LC, Carter JM, Howard BW, Hassenbein DG, Bertram TA (1997) Effects of particle exposure and particle-elicited inflammatory cells on mutation in rat alveolar epithelial cells. Carcinogenesis 18:423–430
Weitzman SA, Weitberg AB, Clark EP, Stossel TP (1985) Phagocytes as carcinogens: malignant transformation produced by human neutrophils. Science 227:1231–1233
Shacter E, Beecham EJ, Covey JM, Kohn KW, Potter M (1988) Activated neutrophils induce prolonged DNA damage in neighboring cells. Carcinogenesis 9:2297–2304
Knaapen AM, Schins RP, Borm PJ, van Schooten FJ (2005) Nitrite enhances neutrophil-induced DNA strand breakage in pulmonary epithelial cells by inhibition of myeloperoxidase. Carcinogenesis 26:1642–1648
Knaapen AM, Seiler F, Schilderman PA, Nehls P, Bruch J, Schins RP, Borm PJ (1999) Neutrophils cause oxidative DNA damage in alveolar epithelial cells. Free Radic Biol Med 27:234–240
Driscoll KE, Hassenbein DG, Howard BW, Isfort RJ, Cody D, Tindal MH, Suchanek M, Carter JM (1995) Cloning, expression, and functional characterization of rat MIP-2: a neutrophil chemoattractant and epithelial cell mitogen. J Leukoc Biol 58:359–364
Murphy PM (1997) Neutrophil receptors for interleukin-8 and related CXC chemokines. Semin Hematol 34:311–318
Tracey KJ, Cerami A (1993) Tumor necrosis factor, other cytokines and disease. Annu Rev Cell Biol 9:317–343
Vassalli P (1992) The pathophysiology of tumor necrosis factors. Annu Rev Immunol 10:411–452
Chung KF (2001) Cytokines in chronic obstructive pulmonary disease. Eur Respir J Suppl 34:50s–59s
Christman JW, Sadikot RT, Blackwell TS (2000) The role of nuclear factor-κB in pulmonary diseases. Chest 117:1482–1487
Lee JI, Burckart GJ (1998) Nuclear factor κB: important transcription factor and therapeutic target. J Clin Pharmacol 38:981–993
Kleinert H, Euchenhofer C, Ihrig-Biedert I, Forstermann U (1996) In murine 3T3 fibroblasts, different second messenger pathways resulting in the induction of NO synthase II (iNOS) converge in the activation of transcription factor NF-κB. J Biol Chem 271:6039–6044
Schmedtje JF Jr, Ji YS, Liu WL, DuBois RN, Runge MS (1997) Hypoxia induces cyclooxygenase-2 via the NF-κB p65 transcription factor in human vascular endothelial cells. J Biol Chem 272:601–608
Collart MA, Baeuerle P, Vassalli P (1990) Regulation of tumor necrosis factor α transcription in macrophages: involvement of four κB-like motifs and of constitutive and inducible forms of NF-κB. Mol Cell Biol 10:1498–1506
Shakhov AN, Collart MA, Vassalli P, Nedospasov SA, Jongeneel CV (1990) Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor α gene in primary macrophages. J Exp Med 171:35–47
Auron PE, Webb AC (1994) Interleukin-1: a gene expression system regulated at multiple levels. Eur Cytokine Netw 5:573–592
Sanceau J, Kaisho T, Hirano T, Wietzerbin J (1995) Triggering of the human interleukin-6 gene by interferon-γ and tumor necrosis factor-α in monocytic cells involves cooperation between interferon regulatory factor-1, NFκB, and Sp1 transcription factors. J Biol Chem 270:27920–27931
Harant H, de Martin R, Andrew PJ, Foglar E, Dittrich C, Lindley IJ (1996) Synergistic activation of interleukin-8 gene transcription by all-trans-retinoic acid and tumor necrosis factor-α involves the transcription factor NFκB. J Biol Chem 271:26954–26961
Roebuck KA, Rahman A, Lakshminarayanan V, Janakidevi K, Malik AB (1995) H2O2 and tumor necrosis factor-α activate intercellular adhesion molecule 1 (ICAM-1) gene transcription through distinct cis-regulatory elements within the ICAM-1 promoter. J Biol Chem 270:18966–18974
Dunn SM, Coles LS, Lang RK, Gerondakis S, Vadas MA, Shannon MF (1994) Requirement for nuclear factor (NF)-κB p65 and NF-interleukin-6 binding elements in the tumor necrosis factor response region of the granulocyte colony-stimulating factor promoter. Blood 83:2469–2479
Israel A, Le Bail O, Hatat D, Piette J, Kieran M, Logeat F, Wallach D, Fellous M, Kourilsky P (1989) TNF stimulates expression of mouse MHC class I genes by inducing an NF κB-like enhancer binding activity which displaces constitutive factors. EMBO J 8:3793–3800
Osborn L, Kunkel S, Nabel GJ (1989) Tumor necrosis factor α and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor κB. Proc Natl Acad Sci USA 86:2336–2340
Ishii H, Fujii T, Hogg JC, Hayashi S, Mukae H, Vincent R, van Eeden SF (2004) Contribution of IL-1 β and TNF-α to the initiation of the peripheral lung response to atmospheric particulates (PM10). Am J Physiol Lung Cell Mol Physiol 287:L176–L183
Jimenez LA, Drost EM, Gilmour PS, Rahman I, Antonicelli F, Ritchie H, MacNee W, Donaldson K (2002) PM(10)-exposed macrophages stimulate a proinflammatory response in lung epithelial cells via TNF-α. Am J Physiol Lung Cell Mol Physiol 282:L237–L248
Janssen-Heininger YM, Macara I, Mossman BT (1999) Cooperativity between oxidants and tumor necrosis factor in the activation of nuclear factor (NF)-κB: requirement of Ras/mitogen-activated protein kinases in the activation of NF-κB by oxidants. Am J Respir Cell Mol Biol 20:942–952
Crapo JD, Barry BE, Gehr P, Bachofen M, Weibel ER (1982) Cell number and cell characteristics of the normal human lung. Am Rev Respir Dis 126:332–337
Laing S, Wang G, Briazova T, Zhang C, Wang A, Zheng Z, Gow A, Chen AF, Rajagopalan S, Chen LC, Sun Q, Zhang K (2010) Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues. Am J Physiol Cell Physiol 299:C736–C749
Lundqvist M, Stigler J, Elia G, Lynch I, Cedervall T, Dawson KA (2008) Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts. Proc Natl Acad Sci USA 105:14265–14270
Kilroe-Smith TA, Webster I, Van Drimmelen M, Marasas L (1973) An insoluble fibrogenic factor in macrophages from guinea pigs exposed to silica. Environ Res 6:298–305
Rabinovitch M, De Stefano MJ (1973) Particle recognition by cultivated macrophages. J Immunol 110:695–701
Bowden DH (1976) The pulmonary macrophage. Environ Health Perspect 16:55–60
Bowden DH (1984) The alveolar macrophage. Environ Health Perspect 55:327–341
Lindbom J, Gustafsson M, Blomqvist G, Dahl A, Gudmundsson A, Swietlicki E, Ljungman AG (2006) Exposure to wear particles generated from studded tires and pavement induces inflammatory cytokine release from human macrophages. Chem Res Toxicol 19:521–530
den Hartigh LJ, Lame MW, Ham W, Kleeman MJ, Tablin F, Wilson DW (2010) Endotoxin and polycyclic aromatic hydrocarbons in ambient fine particulate matter from Fresno, California initiate human monocyte inflammatory responses mediated by reactive oxygen species. Toxicol In Vitro 24:1993–2002
Sakamoto N, Hayashi S, Mukae H, Vincent R, Hogg JC, van Eeden SF (2009) Effect of atorvastatin on PM10-induced cytokine production by human alveolar macrophages and bronchial epithelial cells. Int J Toxicol 28:17–23
Kocbach A, Namork E, Schwarze PE (2008) Pro-inflammatory potential of wood smoke and traffic-derived particles in a monocytic cell line. Toxicology 247:123–132
Brown DM, Donaldson K, Stone V (2004) Effects of PM10 in human peripheral blood monocytes and J774 macrophages. Respir Res 5:29
Brown DM, Hutchison L, Donaldson K, Stone V (2007) The effects of PM10 particles and oxidative stress on macrophages and lung epithelial cells: modulating effects of calcium-signaling antagonists. Am J Physiol Lung Cell Mol Physiol 292:L1444–L1451
Alexis NE, Lay JC, Zeman K, Bennett WE, Peden DB, Soukup JM, Devlin RB, Becker S (2006) Biological material on inhaled coarse fraction particulate matter activates airway phagocytes in vivo in healthy volunteers. J Allergy Clin Immunol 117:1396–1403
Hofer TP, Bitterle E, Beck-Speier I, Maier KL, Frankenberger M, Heyder J, Ziegler-Heitbrock L (2004) Diesel exhaust particles increase LPS-stimulated COX-2 expression and PGE2 production in human monocytes. J Leukoc Biol 75:856–864
Vogel CF, Sciullo E, Wong P, Kuzmicky P, Kado N, Matsumura F (2005) Induction of proinflammatory cytokines and C-reactive protein in human macrophage cell line U937 exposed to air pollution particulates. Environ Health Perspect 113:1536–1541
Beck-Speier I, Dayal N, Karg E, Maier KL, Schumann G, Schulz H, Semmler M, Takenaka S, Stettmaier K, Bors W, Ghio A, Samet JM, Heyder J (2005) Oxidative stress and lipid mediators induced in alveolar macrophages by ultrafine particles. Free Radic Biol Med 38:1080–1092
Mondal K, Stephen Haskill J, Becker S (2000) Adhesion and pollution particle-induced oxidant generation is neither necessary nor sufficient for cytokine induction in human alveolar macrophages. Am J Respir Cell Mol Biol 22:200–208
Pozzi R, De Berardis B, Paoletti L, Guastadisegni C (2003) Inflammatory mediators induced by coarse (PM2.5-10) and fine (PM2.5) urban air particles in RAW 264.7 cells. Toxicology 183:243–254
Pozzi R, De Berardis B, Paoletti L, Guastadisegni C (2005) Winter urban air particles from Rome (Italy): effects on the monocytic-macrophagic RAW 264.7 cell line. Environ Res 99:344–354
Dick CA, Brown DM, Donaldson K, Stone V (2003) The role of free radicals in the toxic and inflammatory effects of four different ultrafine particle types. Inhal Toxicol 15:39–52
Soukup JM, Becker S (2001) Human alveolar macrophage responses to air pollution particulates are associated with insoluble components of coarse material, including particulate endotoxin. Toxicol Appl Pharmacol 171:20–26
Becker S, Mundandhara S, Devlin RB, Madden M (2005) Regulation of cytokine production in human alveolar macrophages and airway epithelial cells in response to ambient air pollution particles: further mechanistic studies. Toxicol Appl Pharmacol 207:269–275
Jalava PI, Salonen RO, Pennanen AS, Sillanpää M, Hälinen AI, Happo MS, Hillamo R, Brunekreef B, Katsouyanni K, Sunyer J, Hirvonen MR (2007) Heterogeneities in inflammatory and cytotoxic responses of RAW 264.7 macrophage cell line to urban air coarse, fine, and ultrafine particles from six European sampling campaigns. Inhal Toxicol 19:213–225
Happo MS, Salonen RO, Hälinen AI, Jalava PI, Pennanen AS, Dormans JA, Gerlofs-Nijland ME, Cassee FR, Kosma VM, Sillanpää M, Hillamo R, Hirvonen MR (2010) Inflammation and tissue damage in mouse lung by single and repeated dosing of urban air coarse and fine particles collected from six European cities. Inhal Toxicol 22:402–416
Ishii H, Hayashi S, Hogg JC, Fujii T, Goto Y, Sakamoto N, Mukae H, Vincent R, van Eeden SF (2005) Alveolar macrophage-epithelial cell interaction following exposure to atmospheric particles induces the release of mediators involved in monocyte mobilization and recruitment. Respir Res 6:87
Kocbach A, Herseth JI, Lag M, Refsnes M, Schwarze PE (2008) Particles from wood smoke and traffic induce differential pro-inflammatory response patterns in co-cultures. Toxicol Appl Pharmacol 232:317–326
Becker S, Soukup J (2003) Coarse(PM(2.5-10)), fine(PM(2.5)), and ultrafine air pollution particles induce/increase immune costimulatory receptors on human blood-derived monocytes but not on alveolar macrophages. J Toxicol Environ Health A 66:847–859
Müller L, Riediker M, Wick P, Mohr M, Gehr P, Rothen-Rutishauser B (2010) Oxidative stress and inflammation response after nanoparticle exposure: differences between human lung cell monocultures and an advanced three-dimensional model of the human epithelial airways. J R Soc Interface 7(Suppl 1):S27–S40
Ohyama M, Otake T, Adachi S, Kobayashi T, Morinaga K (2007) A comparison of the production of reactive oxygen species by suspended particulate matter and diesel exhaust particles with macrophages. Inhal Toxicol 19(Suppl 1):157–160
Zhang Y, Schauer JJ, Shafer MM, Hannigan MP, Dutton SJ (2008) Source apportionment of in vitro reactive oxygen species bioassay activity from atmospheric particulate matter. Environ Sci Technol 42:7502–7509
Huang YC, Soukup J, Harder S, Becker S (2003) Mitochondrial oxidant production by a pollutant dust and NO-mediated apoptosis in human alveolar macrophage. Am J Physiol Cell Physiol 284:C24–C32
Becker S, Soukup JM, Gallagher JE (2002) Differential particulate air pollution induced oxidant stress in human granulocytes, monocytes and alveolar macrophages. Toxicol In Vitro 16:209–218
Aam BB, Fonnum F (2007) Carbon black particles increase reactive oxygen species formation in rat alveolar macrophages in vitro. Arch Toxicol 81:441–446
Chauhan V, Breznan D, Goegan P, Nadeau D, Karthikeyan S, Brook JR, Vincent R (2004) Effects of ambient air particles on nitric oxide production in macrophage cell lines. Cell Biol Toxicol 20:221–239
Lindbom J, Gustafsson M, Blomqvist G, Dahl A, Gudmundsson A, Swietlicki E, Ljungman AG (2007) Wear particles generated from studded tires and pavement induces inflammatory reactions in mouse macrophage cells. Chem Res Toxicol 20:937–946
Salonen RO, Halinen AI, Pennanen AS, Hirvonen MR, Sillanpää M, Hillamo R, Shi T, Borm P, Sandell E, Koskentalo T, Aarnio P (2004) Chemical and in vitro toxicologic characterization of wintertime and springtime urban-air particles with an aerodynamic diameter below 10 microm in Helsinki. Scand J Work Environ Health 30(Suppl 2):80–90
Diociaiuti M, Balduzzi M, De Berardis B, Cattani G, Stacchini G, Ziemacki G, Marconi A, Paoletti L (2001) The two PM(2.5) (fine) and PM(2.5-10) (coarse) fractions: evidence of different biological activity. Environ Res 86:254–262
Becker S, Soukup JM (1998) Decreased CD11b expression, phagocytosis, and oxidative burst in urban particulate pollution-exposed human monocytes and alveolar macrophages. J Toxicol Environ Health A 55:455–477
Kleinman MT, Sioutas C, Chang MC, Boere AJ, Cassee FR (2003) Ambient fine and coarse particle suppression of alveolar macrophage functions. Toxicol Lett 137:151–158
Yang HM, Barger MW, Castranova V, Ma JK, Yang JJ, Ma JY (1999) Effects of diesel exhaust particles (DEP), carbon black, and silica on macrophage responses to lipopolysaccharide: evidence of DEP suppression of macrophage activity. J Toxicol Environ Health A 58:261–278
Amakawa K, Terashima T, Matsuzaki T, Matsumaru A, Sagai M, Yamaguchi K (2003) Suppressive effects of diesel exhaust particles on cytokine release from human and murine alveolar macrophages. Exp Lung Res 29:149–164
Möller W, Brown DM, Kreyling WG, Stone V (2005) Ultrafine particles cause cytoskeletal dysfunctions in macrophages: role of intracellular calcium. Part Fibre Toxicol 2:7
Huang YC, Li Z, Harder SD, Soukup JM (2004) Apoptotic and inflammatory effects induced by different particles in human alveolar macrophages. Inhal Toxicol 16:863–878
Lentsch AB, Shanley TP, Sarma V, Ward PA (1997) In vivo suppression of NF-κB and preservation of IκBα by interleukin-10 and interleukin-13. J Clin Invest 100:2443–2448
Monteiller C, Tran L, MacNee W, Faux S, Jones A, Miller B, Donaldson K (2007) The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface area. Occup Environ Med 64:609–615
Baeza-Squiban A, Bonvallot V, Boland S, Marano F (1999) Diesel exhaust particles increase NF-κB DNA binding activity and c-FOS proto-oncogene expression in human bronchial epithelial cells. Toxicol In Vitro 13:817–822
Boland S, Bonvallot V, Fournier T, Baeza-Squiban A, Aubier M, Marano F (2000) Mechanisms of GM-CSF increase by diesel exhaust particles in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 278:L25–L32
Hashimoto S, Gon Y, Takeshita I, Matsumoto K, Jibiki I, Takizawa H, Kudoh S, Horie T (2000) Diesel exhaust particles activate p38 MAP kinase to produce interleukin 8 and RANTES by human bronchial epithelial cells and N-acetylcysteine attenuates p38 MAP kinase activation. Am J Respir Crit Care Med 161:280–285
Knaapen AM, Schins RP, Steinfartz Y, Höhr D, Dunemann L, Borm PJ (2000) Ambient particulate matter induces oxidative DNA damage in lung epithelial cells. Inhal Toxicol 12:125–132
Don Porto Carero A, Hoet PH, Verschaeve L, Schoeters G, Nemery B (2001) Genotoxic effects of carbon black particles, diesel exhaust particles, and urban air particulates and their extracts on a human alveolar epithelial cell line (A549) and a human monocytic cell line (THP-1). Environ Mol Mutagen 37:155–163
Prahalad AK, Inmon J, Dailey LA, Madden MC, Ghio AJ, Gallagher JE (2001) Air pollution particles mediated oxidative DNA base damage in a cell free system and in human airway epithelial cells in relation to particulate metal content and bioreactivity. Chem Res Toxicol 14:879–887
Danielsen PH, Loft S, Møller P (2008) DNA damage and cytotoxicity in type II lung epithelial (A549) cell cultures after exposure to diesel exhaust and urban street particles. Part Fibre Toxicol 5:6
Dellinger B, Pryor WA, Cueto R, Squadrito GL, Hegde V, Deutsch WA (2001) Role of free radicals in the toxicity of airborne fine particulate matter. Chem Res Toxicol 14:1371–1377
Ghio AJ, Carter JD, Dailey LA, Devlin RB, Samet JM (1999) Respiratory epithelial cells demonstrate lactoferrin receptors that increase after metal exposure. Am J Physiol 276:L933–L940
Albrecht C, Schins RP, Hohr D, Becker A, Shi T, Knaapen AM, Borm PJ (2004) Inflammatory time course after quartz instillation: role of tumor necrosis factor-α and particle surface. Am J Respir Cell Mol Biol 31:292–301
Timblin C, BeruBe K, Churg A, Driscoll K, Gordon T, Hemenway D, Walsh E, Cummins AB, Vacek P, Mossman B (1998) Ambient particulate matter causes activation of the c-jun kinase/stress-activated protein kinase cascade and DNA synthesis in lung epithelial cells. Cancer Res 58:4543–4547
Tamaoki J, Isono K, Takeyama K, Tagaya E, Nakata J, Nagai A (2004) Ultrafine carbon black particles stimulate proliferation of human airway epithelium via EGF receptor-mediated signaling pathway. Am J Physiol Lung Cell Mol Physiol 287:L1127–L1133
Sydlik U, Bierhals K, Soufi M, Abel J, Schins RP, Unfried K (2006) Ultrafine carbon particles induce apoptosis and proliferation in rat lung epithelial cells via specific signaling pathways both using EGF-R. Am J Physiol Lung Cell Mol Physiol 291:L725–L733
Rumelhard M, Ramgolam K, Hamel R, Marano F, Baeza-Squiban A (2007) Expression and role of EGFR ligands induced in airway cells by PM2.5 and its components. Eur Respir J 30:1064–1073
Baulig A, Blanchet S, Rumelhard M, Lacroix G, Marano F, Baeza-Squiban A (2007) Fine urban atmospheric particulate matter modulates inflammatory gene and protein expression in human bronchial epithelial cells. Front Biosci 12:771–782
Blanchet S, Ramgolam K, Baulig A, Marano F, Baeza-Squiban A (2004) Fine particulate matter induces amphiregulin secretion by bronchial epithelial cells. Am J Respir Cell Mol Biol 30:421–427
Camatini M, Corvaja V, Pezzolato E, Mantecca P, Gualtieri M (2012) PM10-biogenic fraction drives the seasonal variation of proinflammatory response in A549 cells. Environ Toxicol 27(2):63–73
Baulig A, Singh S, Marchand A, Schins R, Barouki R, Garlatti M, Marano F, Baeza-Squiban A (2009) Role of Paris PM(2.5) components in the pro-inflammatory response induced in airway epithelial cells. Toxicology 261:126–135
Jimenez LA, Thompson J, Brown DA, Rahman I, Antonicelli F, Duffin R, Drost EM, Hay RT, Donaldson K, MacNee W (2000) Activation of NF-κB by PM(10) occurs via an iron-mediated mechanism in the absence of IκB degradation. Toxicol Appl Pharmacol 166:101–110
Fujii T, Hogg JC, Keicho N, Vincent R, Van Eeden SF, Hayashi S (2003) Adenoviral E1A modulates inflammatory mediator expression by lung epithelial cells exposed to PM10. Am J Physiol Lung Cell Mol Physiol 284:L290–L297
Gilmour PS, Rahman I, Hayashi S, Hogg JC, Donaldson K, MacNee W (2001) Adenoviral E1A primes alveolar epithelial cells to PM(10)-induced transcription of interleukin-8. Am J Physiol Lung Cell Mol Physiol 281:L598–L606
Devalia JL, Bayram H, Abdelaziz MM, Sapsford RJ, Davies RJ (1999) Differences between cytokine release from bronchial epithelial cells of asthmatic patients and non-asthmatic subjects: effect of exposure to diesel exhaust particles. Int Arch Allergy Immunol 118:437–439
Gursinsky T, Ruhs S, Friess U, Diabate S, Krug HF, Silber RE, Simm A (2006) Air pollution-associated fly ash particles induce fibrotic mechanisms in primary fibroblasts. Biol Chem 387:1411–1420
Deng F, Guo X, Liu H, Fang X, Yang M, Chen W (2007) Effects of dust storm PM2.5 on cell proliferation and cell cycle in human lung fibroblasts. Toxicol In Vitro 21:632–638
Lindroos PM, Coin PG, Badgett A, Morgan DL, Bonner JC (1997) Alveolar macrophages stimulated with titanium dioxide, chrysotile asbestos, and residual oil fly ash upregulate the PDGF receptor-α on lung fibroblasts through an IL-1β-dependent mechanism. Am J Respir Cell Mol Biol 16:283–292
Bonner JC, Rice AB, Lindroos PM, O’Brien PO, Dreher KL, Rosas I, Alfaro-Moreno E, Osornio-Vargas AR (1998) Induction of the lung myofibroblast PDGF receptor system by urban ambient particles from Mexico City. Am J Respir Cell Mol Biol 19:672–680
Kim H, Liu X, Kobayashi T, Kohyama T, Wen FQ, Romberger DJ, Conner H, Gilmour PS, Donaldson K, MacNee W, Rennard SI (2003) Ultrafine carbon black particles inhibit human lung fibroblast-mediated collagen gel contraction. Am J Respir Cell Mol Biol 28:111–121
Kiama SG, Cochand L, Karlsson L, Nicod LP, Gehr P (2001) Evaluation of phagocytic activity in human monocyte-derived dendritic cells. J Aerosol Med 14:289–299
Porter M, Karp M, Killedar S, Bauer SM, Guo J, Williams D, Breysse P, Georas SN, Williams MA (2007) Diesel-enriched particulate matter functionally activates human dendritic cells. Am J Respir Cell Mol Biol 37:706–719
Williams MA, Porter M, Horton M, Guo J, Roman J, Williams D, Breysse P, Georas SN (2007) Ambient particulate matter directs nonclassic dendritic cell activation and a mixed TH1/TH2-like cytokine response by naive CD4+ T cells. J Allergy Clin Immunol 119:488–497
Braun A, Bewersdorff M, Lintelmann J, Matuschek G, Jakob T, Göttlicher M, Schober W, Buters JT, Behrendt H, Mempel M (2010) Differential impact of diesel particle composition on pro-allergic dendritic cell function. Toxicol Sci 113:85–94
Chan RC, Wang M, Li N, Yanagawa Y, Onoe K, Lee JJ, Nel AE (2006) Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation. J Allergy Clin Immunol 118:455–465
Viera L, Chen K, Nel A, Lloret MG (2009) The impact of air pollutants as an adjuvant for allergic sensitization and asthma. Curr Allergy Asthma Rep 9:327–333
Williams MA, Rangasamy T, Bauer SM, Killedar S, Karp M, Kensler TW, Yamamoto M, Breysse P, Biswal S, Georas SN (2008) Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter. J Immunol 181:4545–4559
Koike E, Takano H, Inoue K, Yanagisawa R, Kobayashi T (2008) Carbon black nanoparticles promote the maturation and function of mouse bone marrow-derived dendritic cells. Chemosphere 73:371–376
Bleck B, Tse DB, Jaspers I, Curotto de Lafaille MA, Reibman J (2006) Diesel exhaust particle-exposed human bronchial epithelial cells induce dendritic cell maturation. J Immunol 176:7431–7437
Ying S, O’Connor B, Ratoff J, Meng Q, Mallett K, Cousins D, Robinson D, Zhang G, Zhao J, Lee TH, Corrigan C (2005) Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J Immunol 174:8183–8190
Bleck B, Tse DB, Curotto de Lafaille MA, Zhang F, Reibman J (2008) Diesel exhaust particle-exposed human bronchial epithelial cells induce dendritic cell maturation and polarization via thymic stromal lymphopoietin. J Clin Immunol 28:147–156
Li R, Ning Z, Cui J, Khalsa B, Ai L, Takabe W, Beebe T, Majumdar R, Sioutas C, Hsiai T (2009) Ultrafine particles from diesel engines induce vascular oxidative stress via JNK activation. Free Radic Biol Med 46:775–782
Mo Y, Wan R, Chien S, Tollerud DJ, Zhang Q (2009) Activation of endothelial cells after exposure to ambient ultrafine particles: the role of NADPH oxidase. Toxicol Appl Pharmacol 236:183–193
Wei H, Wei D, Yi S, Zhang F, Ding W (2011) Oxidative stress induced by urban fine particles in cultured EA.hy926 cells. Hum Exp Toxicol 30:579–590
Totlandsdal AI, Refsnes M, Skomedal T, Osnes JB, Schwarze PE, Lag M (2008) Particle-induced cytokine responses in cardiac cell cultures―the effect of particles versus soluble mediators released by particle-exposed lung cells. Toxicol Sci 106:233–241
Qu S, Liberda EN, Qu Q, Chen LC (2010) In vitro assessment of the inflammatory response of respiratory endothelial cells exposed to particulate matter. J Toxicol Environ Health A 73:1113–1121
Yamawaki H, Iwai N (2006) Mechanisms underlying nano-sized air-pollution-mediated progression of atherosclerosis: carbon black causes cytotoxic injury/inflammation and inhibits cell growth in vascular endothelial cells. Circ J 70:129–140
Alfaro-Moreno E, Lopez-Marure R, Montiel-Davalos A, Symonds P, Osornio-Vargas AR, Rosas I, Clifford Murray J (2007) E-Selectin expression in human endothelial cells exposed to PM10: the role of endotoxin and insoluble fraction. Environ Res 103:221–228
Kristovich R, Knight DA, Long JF, Williams MV, Dutta PK, Waldman WJ (2004) Macrophage-mediated endothelial inflammatory responses to airborne particulates: impact of particulate physicochemical properties. Chem Res Toxicol 17:1303–1312
Montiel-Davalos A, Alfaro-Moreno E, Lopez-Marure R (2007) PM2.5 and PM10 induce the expression of adhesion molecules and the adhesion of monocytic cells to human umbilical vein endothelial cells. Inhal Toxicol 19(Suppl 1):91–98
Li R, Ning Z, Cui J, Yu F, Sioutas C, Hsiai T (2010) Diesel exhaust particles modulate vascular endothelial cell permeability: implication of ZO-1 expression. Toxicol Lett 197:163–168
Wang T, Chiang ET, Moreno-Vinasco L, Lang GD, Pendyala S, Samet JM, Geyh AS, Breysse PN, Chillrud SN, Natarajan V, Garcia JG (2010) Particulate matter disrupts human lung endothelial barrier integrity via ROS- and p38 MAPK-dependent pathways. Am J Respir Cell Mol Biol 42:442–449
Knaapen AM, den Hartog GJ, Bast A, Borm PJ (2001) Ambient particulate matter induces relaxation of rat aortic rings in vitro. Hum Exp Toxicol 20:259–265
Miller MR, Borthwick SJ, Shaw CA, McLean SG, McClure D, Mills NL, Duffin R, Donaldson K, Megson IL, Hadoke PW, Newby DE (2009) Direct impairment of vascular function by diesel exhaust particulate through reduced bioavailability of endothelium-derived nitric oxide induced by superoxide free radicals. Environ Health Perspect 117:611–616
Block ML, Wu X, Pei Z, Li G, Wang T, Qin L, Wilson B, Yang J, Hong JS, Veronesi B (2004) Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidase. FASEB J 18:1618–1620
Hartz AM, Bauer B, Block ML, Hong JS, Miller DS (2008) Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier. FASEB J 22:2723–2733
Sama P, Long TC, Hester S, Tajuba J, Parker J, Chen LC, Veronesi B (2007) The cellular and genomic response of an immortalized microglia cell line (BV2) to concentrated ambient particulate matter. Inhal Toxicol 19:1079–1087
Shin JA, Lee EJ, Seo SM, Kim HS, Kang JL, Park EM (2010) Nanosized titanium dioxide enhanced inflammatory responses in the septic brain of mouse. Neuroscience 165:445–454
Campbell A, Araujo JA, Li H, Sioutas C, Kleinman M (2009) Particulate matter induced enhancement of inflammatory markers in the brains of apolipoprotein E knockout mice. J Nanosci Nanotechnol 9:5099–5104
Harkema JR, Wagner JG, Kaminski NE, Morishita M, Keeler GJ, McDonald JD, Barrett EG (2009) Effects of concentrated ambient particles and diesel engine exhaust on allergic airway disease in Brown Norway rats. Res Rep Health Eff Inst 145:5–55
Mills NL, Robinson SD, Fokkens PH, Leseman DL, Miller MR, Anderson D, Freney EJ, Heal MR, Donovan RJ, Blomberg A, Sandström T, MacNee W, Boon NA, Donaldson K, Newby DE, Cassee FR (2008) Exposure to concentrated ambient particles does not affect vascular function in patients with coronary heart disease. Environ Health Perspect 116:709–715
Stringer B, Imrich A, Kobzik L (1996) Lung epithelial cell (A549) interaction with unopsonized environmental particulates: quantitation of particle-specific binding and IL-8 production. Exp Lung Res 22:495–508
Barlow PG, Brown DM, Donaldson K, MacCallum J, Stone V (2008) Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure. Cell Biol Toxicol 24:243–252
Gilmour MI, McGee J, Duvall RM, Dailey L, Daniels M, Boykin E, Cho SH, Doerfler D, Gordon T, Devlin RB (2007) Comparative toxicity of size-fractionated airborne particulate matter obtained from different cities in the United States. Inhal Toxicol 19(Suppl 1):7–16
Rao KM, Ma JY, Meighan T, Barger MW, Pack D, Vallyathan V (2005) Time course of gene expression of inflammatory mediators in rat lung after diesel exhaust particle exposure. Environ Health Perspect 113:612–617
Marano F, Boland S, Bonvallot V, Baulig A, Baeza-Squiban A (2002) Human airway epithelial cells in culture for studying the molecular mechanisms of the inflammatory response triggered by diesel exhaust particles. Cell Biol Toxicol 18:315–320
Salnikow K, Li X, Lippmann M (2004) Effect of nickel and iron co-exposure on human lung cells. Toxicol Appl Pharmacol 196:258–265
Zanchi AC, Saiki M, Saldiva PH, Barros HM, Rhoden CR (2010) Hippocampus lipid peroxidation induced by residual oil fly ash intranasal instillation versus habituation to the open field. Inhal Toxicol 22:84–88
Steerenberg PA, Withagen CE, Dormans JA, van Dalen WJ, van Loveren H, Casee FR (2003) Adjuvant activity of various diesel exhaust and ambient particles in two allergic models. J Toxicol Environ Health A 66:1421–1439
Smith KR, Veranth JM, Kodavanti UP, Aust AE, Pinkerton KE (2006) Acute pulmonary and systemic effects of inhaled coal fly ash in rats: comparison to ambient environmental particles. Toxicol Sci 93:390–399
Donaldson K, Mills N, MacNee W, Robinson S, Newby D (2005) Role of inflammation in cardiopulmonary health effects of PM. Toxicol Appl Pharmacol 207:483–488
Stone V, Tuinman M, Vamvakopoulos JE, Shaw J, Brown D, Petterson S, Faux SP, Borm P, MacNee W, Michaelangeli F, Donaldson K (2000) Increased calcium influx in a monocytic cell line on exposure to ultrafine carbon black. Eur Respir J 15:297–303
Tong H, McGee JK, Saxena RK, Kodavanti UP, Devlin RB, Gilmour MI (2009) Influence of acid functionalization on the cardiopulmonary toxicity of carbon nanotubes and carbon black particles in mice. Toxicol Appl Pharmacol 239:224–232
Wilson MR, Lightbody JH, Donaldson K, Sales J, Stone V (2002) Interactions between ultrafine particles and transition metals in vivo and in vitro. Toxicol Appl Pharmacol 184:172–179
Hussain S, Vanoirbeek JA, Luyts K, De Vooght V, Verbeken E, Thomassen LC, Martens JA, Dinsdale D, Boland S, Marano F, Nemery B, Hoet PH (2011) Lung exposure to nanoparticles modulates an asthmatic response in a mouse model of asthma. Eur Respir J 37:299–309
Oberdörster G, Finkelstein JN, Johnston C, Gelein R, Cox C, Baggs R, Elder AC (2000) Acute pulmonary effects of ultrafine particles in rats and mice. Res Rep Health Eff Inst 96:5–74 (discussion 75–86)
Singh S, Shi T, Duffin R, Albrecht C, van Berlo D, Hohr D, Fubini B, Martra G, Fenoglio I, Borm PJ, Schins RP (2007) Endocytosis, oxidative stress and IL-8 expression in human lung epithelial cells upon treatment with fine and ultrafine TiO2: role of the specific surface area and of surface methylation of the particles. Toxicol Appl Pharmacol 222:141–151
Curjuric I, Imboden M, Schindler C, Downs SH, Hersberger M, Liu SL, Matyas G, Russi EW, Schwartz J, Thun GA, Postma DS, Rochat T, Probst-Hensch NM (2010) HMOX1 and GST variants modify attenuation of FEF25-75% decline due to PM10 reduction. Eur Respir J 35:505–514
Ren C, Baccarelli A, Wilker E, Suh H, Sparrow D, Vokonas P, Wright R, Schwartz J (2010) Lipid and endothelium-related genes, ambient particulate matter, and heart rate variability―the VA normative aging study. J Epidemiol Community Health 64:49–56
Wilker E, Mittleman MA, Litonjua AA, Poon A, Baccarelli A, Suh H, Wright RO, Sparrow D, Vokonas P, Schwartz J (2009) Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter. Environ Health Perspect 117:935–940
Imboden M, Schwartz J, Schindler C, Curjuric I, Berger W, Liu SL, Russi EW, Ackermann-Liebrich U, Rochat T, Probst-Hensch NM (2009) Decreased PM10 exposure attenuates age-related lung function decline: genetic variants in p53, p21, and CCND1 modify this effect. Environ Health Perspect 117:1420–1427
Wenten M, Gauderman WJ, Berhane K, Lin PC, Peters J, Gilliland FD (2009) Functional variants in the catalase and myeloperoxidase genes, ambient air pollution, and respiratory-related school absences: an example of epistasis in gene-environment interactions. Am J Epidemiol 170:1494–1501
Peters A, Greven S, Heid IM, Baldari F, Breitner S, Bellander T, Chrysohoou C, Illig T, Jacquemin B, Koenig W, Lanki T, Nyberg F, Pekkanen J, Pistelli R, Rückerl R, Stefanadis C, Schneider A, Sunyer J, Wichmann HE (2009) Fibrinogen genes modify the fibrinogen response to ambient particulate matter. Am J Respir Crit Care Med 179:484–491
Baccarelli A, Cassano PA, Litonjua A, Park SK, Suh H, Sparrow D, Vokonas P, Schwartz J (2008) Cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphisms. Circulation 117:1802–1809
Park GY, Christman JW (2006) Involvement of cyclooxygenase-2 and prostaglandins in the molecular pathogenesis of inflammatory lung diseases. Am J Physiol Lung Cell Mol Physiol 290:L797–L805
Montiel-Davalos A, Ibarra-Sanchez Mde J, Ventura-Gallegos JL, Alfaro-Moreno E, Lopez-Marure R (2010) Oxidative stress and apoptosis are induced in human endothelial cells exposed to urban particulate matter. Toxicol In Vitro 24:135–141
Zhao Y, Usatyuk PV, Gorshkova IA, He D, Wang T, Moreno-Vinasco L, Geyh AS, Breysse PN, Samet JM, Spannhake EW, Garcia JG, Natarajan V (2009) Regulation of COX-2 expression and IL-6 release by particulate matter in airway epithelial cells. Am J Respir Cell Mol Biol 40:19–30
Dagher Z, Garcon G, Billet S, Verdin A, Ledoux F, Courcot D, Aboukais A, Shirali P (2007) Role of nuclear factor-κB activation in the adverse effects induced by air pollution particulate matter (PM2.5) in human epithelial lung cells (L132) in culture. J Appl Toxicol 27:284–290
Churg A, Xie C, Wang X, Vincent R, Wang RD (2005) Air pollution particles activate NF-κB on contact with airway epithelial cell surfaces. Toxicol Appl Pharmacol 208:37–45
Maciejczyk P, Chen LC (2005) Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice VIII. Source-related daily variations in in vitro responses to CAPs. Inhal Toxicol 17:243–253
Nam HY, Choi BH, Lee JY, Lee SG, Kim YH, Lee KH, Yoon HK, Song JS, Kim HJ, Lim Y (2004) The role of nitric oxide in the particulate matter (PM2.5)-induced NFκB activation in lung epithelial cells. Toxicol Lett 148:95–102
Shukla A, Timblin C, BeruBe K, Gordon T, McKinney W, Driscoll K, Vacek P, Mossman BT (2000) Inhaled particulate matter causes expression of nuclear factor (NF)-κB-related genes and oxidant-dependent NF-κB activation in vitro. Am J Respir Cell Mol Biol 23:182–187
Li R, Ning Z, Majumdar R, Cui J, Takabe W, Jen N, Sioutas C, Hsiai T (2010) Ultrafine particles from diesel vehicle emissions at different driving cycles induce differential vascular pro-inflammatory responses: implication of chemical components and NF-κB signaling. Part Fibre Toxicol 7:6
Tal TL, Simmons SO, Silbajoris R, Dailey L, Cho SH, Ramabhadran R, Linak W, Reed W, Bromberg PA, Samet JM (2010) Differential transcriptional regulation of IL-8 expression by human airway epithelial cells exposed to diesel exhaust particles. Toxicol Appl Pharmacol 243:46–54
Totlandsdal AI, Refsnes M, Lag M (2010) Mechanisms involved in ultrafine carbon black-induced release of IL-6 from primary rat epithelial lung cells. Toxicol In Vitro 24:10–20
Alessandrini F, Beck-Speier I, Krappmann D, Weichenmeier I, Takenaka S, Karg E, Kloo B, Schulz H, Jakob T, Mempel M, Behrendt H (2009) Role of oxidative stress in ultrafine particle-induced exacerbation of allergic lung inflammation. Am J Respir Crit Care Med 179:984–991
Hirota R, Akimaru K, Nakamura H (2008) In vitro toxicity evaluation of diesel exhaust particles on human eosinophilic cell. Toxicol In Vitro 22:988–994
Mroz RM, Schins RP, Li H, Drost EM, Macnee W, Donaldson K (2007) Nanoparticle carbon black driven DNA damage induces growth arrest and AP-1 and NFκB DNA binding in lung epithelial A549 cell line. J Physiol Pharmacol 58(Suppl 5):461–470
Lee CC, Cheng YW, Kang JJ (2005) Motorcycle exhaust particles induce IL-8 production through NF-κB activation in human airway epithelial cells. J Toxicol Environ Health A 68:1537–1555
Yun YP, Joo JD, Lee JY, Nam HY, Kim YH, Lee KH, Lim CS, Kim HJ, Lim YG, Lim Y (2005) Induction of nuclear factor-κB activation through TAK1 and NIK by diesel exhaust particles in L2 cell lines. Toxicol Lett 155:337–342
Ma C, Wang J, Luo J (2004) Activation of nuclear factor κB by diesel exhaust particles in mouse epidermal cells through phosphatidylinositol 3-kinase/Akt signaling pathway. Biochem Pharmacol 67:1975–1983
Roberts E, Charboneau L, Espina V, Liotta L, Petricoin E, Dreher K (2004) Application of laser capture microdissection and protein microarray technologies in the molecular analysis of airway injury following pollution particle exposure. J Toxicol Environ Health A 67:851–861
Takizawa H, Abe S, Okazaki H, Kohyama T, Sugawara I, Saito Y, Ohtoshi T, Kawasaki S, Desaki M, Nakahara K, Zamamoto K, Matsushima K, Tanaka M, Sagai M, Kudoh S (2003) Diesel exhaust particles upregulate eotaxin gene expression in human bronchial epithelial cells via nuclear factor-κB-dependent pathway. Am J Physiol Lung Cell Mol Physiol 284:L1055–L1062
Zhou YM, Zhong CY, Kennedy IM, Leppert VJ, Pinkerton KE (2003) Oxidative stress and NFκB activation in the lungs of rats: a synergistic interaction between soot and iron particles. Toxicol Appl Pharmacol 190:157–169
Zhou YM, Zhong CY, Kennedy IM, Pinkerton KE (2003) Pulmonary responses of acute exposure to ultrafine iron particles in healthy adult rats. Environ Toxicol 18:227–235
Samet JM, Silbajoris R, Huang T, Jaspers I (2002) Transcription factor activation following exposure of an intact lung preparation to metallic particulate matter. Environ Health Perspect 110:985–990
Kawasaki S, Takizawa H, Takami K, Desaki M, Okazaki H, Kasama T, Kobayashi K, Yamamoto K, Nakahara K, Tanaka M, Sagai M, Ohtoshi T (2001) Benzene-extracted components are important for the major activity of diesel exhaust particles: effect on interleukin-8 gene expression in human bronchial epithelial cells. Am J Respir Cell Mol Biol 24:419–426
Takizawa H, Ohtoshi T, Kawasaki S, Kohyama T, Desaki M, Kasama T, Kobayashi K, Nakahara K, Yamamoto K, Matsushima K, Kudoh S (1999) Diesel exhaust particles induce NF-κB activation in human bronchial epithelial cells in vitro: importance in cytokine transcription. J Immunol 162:4705–4711
Drumm K, Messner C, Kienast K (1999) Reactive oxygen intermediate-release of fibre-exposed monocytes increases inflammatory cytokine-mRNA level, protein tyrosine kinase and NF-κB activity in co-cultured bronchial epithelial cells (BEAS-2B). Eur J Med Res 4:257–263
Oettinger R, Drumm K, Knorst M, Krinyak P, Smolarski R, Kienast K (1999) Production of reactive oxygen intermediates by human macrophages exposed to soot particles and asbestos fibers and increase in NF-κB p50/p105 mRNA. Lung 177:343–354
Drumm K, Oettinger R, Smolarski R, Bay M, Kienast K (1998) In vitro study of human alveolar macrophages inflammatory mediator transcriptions and releases induced by soot FR 101, Printex 90, titandioxide and Chrysotile B. Eur J Med Res 3:432–438
Quay JL, Reed W, Samet J, Devlin RB (1998) Air pollution particles induce IL-6 gene expression in human airway epithelial cells via NF-κB activation. Am J Respir Cell Mol Biol 19:98–106
Watterson TL, Sorensen J, Martin R, Coulombe RA Jr (2007) Effects of PM2.5 collected from Cache Valley Utah on genes associated with the inflammatory response in human lung cells. J Toxicol Environ Health A 70:1731–1744
Ramage L, Guy K (2004) Expression of C-reactive protein and heat-shock protein-70 in the lung epithelial cell line A549, in response to PM10 exposure. Inhal Toxicol 16:447–452
Reibman J, Hsu Y, Chen LC, Kumar A, Su WC, Choy W, Talbot A, Gordon T (2002) Size fractions of ambient particulate matter induce granulocyte macrophage colony-stimulating factor in human bronchial epithelial cells by mitogen-activated protein kinase pathways. Am J Respir Cell Mol Biol 27:455–462
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van Berlo, D., Hullmann, M., Schins, R.P.F. (2012). Toxicology of Ambient Particulate Matter. In: Luch, A. (eds) Molecular, Clinical and Environmental Toxicology. Experientia Supplementum, vol 101. Springer, Basel. https://doi.org/10.1007/978-3-7643-8340-4_7
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