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Effect of Platelet-Activating Factor Antagonist on Brain Injury in Rats

  • Conference paper
Brain Edema IX

Part of the book series: Acta Neurochirurgica ((NEUROCHIRURGICA,volume 60))

  • 195 Accesses

Summary

The ability of a platelet-activating factor (PAF) antagonist to reduce infarct size has been reported in a animal model of focal brain ischemia. The authors studied the effect of PAF antagonist (TCV-309) on cold brain injury in rats. Twenty–four hours after injury, water content was determined by both dry ing-weighing and spesific gravimetric techniques, and ischemic brain damage was assesed with 2,3,5-triphenyltetrazolium chloride in multiple coronal sections. Pretreatment with TCV-309 (lmg/kg) significantly reduced the water content (p < 0.01) and volume of ischemic damage (p < 0.001) produced by the cold brain injury. These results indicate that PAF antagonist can ameliorate secondary brain tissue damage following brain injury.

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume-shi, Fukuoka-ken 830, Japan

    Takashi Tokutomi M.D., M. Sigemori, T. Kikuchi & M. Hirohata

Authors
  1. Takashi Tokutomi M.D.
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  2. M. Sigemori
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  3. T. Kikuchi
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  4. M. Hirohata
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Musashino Red-Cross Hospital, Tokyo, Japan

    Umeo Ito M.D. (Director and Neurosurgeon in Chief) (Director and Neurosurgeon in Chief)

  2. Institut für Chirurgische Forschung, Ludwig-Maximilians-Universität, München, Federal Republic of Germany

    Alexander Baethmann M.D. (Professor) (Professor)

  3. Max-Planck Institut für Neurologische Forschung, Köln, Federal Republic of Germany

    Konstantin-A. Hossmann M.D. (Professor) (Professor)

  4. Department of Neuropathology, Tokyo Medical and Dental University, Tokyo, Japan

    Toshihiko Kuroiwa M.D. (Associate Professor) (Associate Professor)

  5. Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia, USA

    Anthony Marmarou Ph.D. (Professor) (Professor)

  6. Neurochirurgische Klinik, Ludwig-Maximilians-Universität, München, Federal Republic of Germany

    Hans-J. Reulen M.D. (Professor) (Professor)

  7. Department of Neurosurgery, Tokyo Women’s Medical College, Tokyo, Japan

    Kintomo Takakura M.D. (Professor) (Professor)

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© 1994 Springer-Verlag

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Tokutomi, T., Sigemori, M., Kikuchi, T., Hirohata, M. (1994). Effect of Platelet-Activating Factor Antagonist on Brain Injury in Rats. In: Ito, U., et al. Brain Edema IX. Acta Neurochirurgica, vol 60. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9334-1_139

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  • DOI: https://doi.org/10.1007/978-3-7091-9334-1_139

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9336-5

  • Online ISBN: 978-3-7091-9334-1

  • eBook Packages: Springer Book Archive

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