Skip to main content
SpringerLink
Log in

Survival and Fibre Outgrowth of Neuronal Cells Transplanted into Brain Areas Associated with Interstitial Oedema

  • Conference paper
Brain Edema VIII

Part of the book series: Acta Neurochirurgica ((NEUROCHIRURGICA,volume 51))

  • 137 Accesses

Summary

The influence of interstitial oedema on the survival of fetal raphe cells transplanted into serotonin (5-HT)-denervated rats and the fibre outgrowth from these cells was investigated. Fetal raphe cells were transplanted into the corpus callosum in which long-lasting interstitial oedema had been induced by intracisternal kaolin injection. The 5-HT and 5HIAA levels in the corpus callosum were restored to their maximum within 5–6 weeks post-transplantation regardless of whether interstitial oedema was induced or not. Furthermore, it was appeared that the presence of interstitial oedema even facilitated fibre growth as demonstrated by the 5-HT immunohistochemistry and the restoration of the 5-HT and 5-HIAA levels in brain areas distant from the transplantation sites. These results imply favourable effects of interstitial oedema on the survival of transplanted raphe cells and their fibre outgrowth.

This work was supported by a Japan Education Ministry Grant (6048033, 1986–1989) and a Grant from the Ministry of Health and Welfare of Japan (1983–1987).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Auerbach S, Zhou F, Jacobs BL, Azmitia E (1985) Serotonin turnover in raphe neurons transplanted into rat hippocampus. Neurosci Lett 61: 147–152

    Article  PubMed  CAS  Google Scholar 

  2. Bjorklund A, Stenevi U, Schmidt RH, Dunnet SB, Gage FH (1983) Intracerebral grafting of neuronal cell suspension. I. Introduction and general methods of preparation. Acta Physiol Scand 522 [Suppl]: 1–7

    CAS  Google Scholar 

  3. Gonzalez-Darder J, Barbera J, Cerda-Nicolas M, Segura D, Broseta J, Barcia-Salorio JL (1984) Sequential morphological and functional changes in kaolin-induced hydrocephalus. J Neurosurg 61: 918–924

    Article  PubMed  CAS  Google Scholar 

  4. Hochwald G (1984) Animal models of hydrocephalus. In: Shapiro K, Marmarou A, Portnoy H (eds) Hydrocephylus. Raven Press, New York, pp 199–213

    Google Scholar 

  5. Nishino H, Ono T, Takahashi J (1986) Transplants in the peri and intraventricular region grow better than those in the central parenchyma of the caudate. Neurosci Lett 64: 184–190

    Article  PubMed  CAS  Google Scholar 

  6. Tsubokawa T, Katayama Y, Miyazaki S, Ogawa H, Iwasaki M, Shibanoki S, Ishikawa K (1988) Supranormal levels of serotonin and its metabolite after raphe cell transplantation in serotonindenervated rat hippocampus. Brain Res Bull 20: 303–306

    Article  PubMed  CAS  Google Scholar 

  7. Tsubokawa T, Katayama Y, Kawamata T (1988) Impaired hippocampal plasticity in experimental chronic hydrocephalus. Brain Injury 2: 19–30

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan

    Y. Katayama, S. Miyazaki, H. Ogawa & M. Koshinaga

  2. Departments of Pharmacology, Nihon University School of Medicine, Tokyo, Japan

    K. Ishikawa

  3. Department of Neurological Surgery, Nihon University School of Medicine, Tokyo 173, Japan

    T. Tsubokawa M.D.

Authors
  1. T. Tsubokawa M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Y. Katayama
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Miyazaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. Ogawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Koshinaga
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. K. Ishikawa
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Bern, Switzerland

    Hans-J. Reulen

  2. Institut für chirurgische Forschung, Ludwig-Maximilians-Universität, Klinikum Grosshadern, München, Federal Republic of Germany

    Alexander Baethmann

  3. Department of Neurological Surgery, State University of New York at Stony Brook, New York, USA

    Joseph Fenstermacher

  4. Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia, USA

    Anthony Marmarou

  5. Laboratory of Neuropathology and Neuroanatomical Sciences, National Institutes of Health, Bethesda, Maryland, USA

    Maria Spatz

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag

About this paper

Cite this paper

Tsubokawa, T., Katayama, Y., Miyazaki, S., Ogawa, H., Koshinaga, M., Ishikawa, K. (1990). Survival and Fibre Outgrowth of Neuronal Cells Transplanted into Brain Areas Associated with Interstitial Oedema. In: Reulen, HJ., Baethmann, A., Fenstermacher, J., Marmarou, A., Spatz, M. (eds) Brain Edema VIII. Acta Neurochirurgica, vol 51. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9115-6_90

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-9115-6_90

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9117-0

  • Online ISBN: 978-3-7091-9115-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation