Abstract
We have been investigating the role of PKC in the vascular smooth muscle cells in the development and maintenance of cerebral vasospasm after subarachnoid haemorrhage (SAH) [3, 4, 5], and our previous experimental results on the canine basilar artery showed that measurement of PKC activity was significantly enhanced in the membrane fraction of the vascular smooth muscle cells of cerebral vasospastic arteries in a canine subarachnoid haemorrhage model [4, 5], and that the time course of the development of angiographic vasospasm and increased PKC activity in the membrane fraction were closely correlated with time. PKC activity was not significantly increased in the mild vasospasm model compared to the control, but the increase was significant in the severe vasospasm model [5]. These results indicated that PKC plays a pivotal role in the development of vasospasm following SAH.
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© 2001 Springer-Verlag
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Nishizawa, S. et al. (2001). Which Protein Kinase C Isoforms are Involved in the Development of Vasospasm after Subarachnoid Haemorrhage?. In: Seiler, R.W., Steiger, HJ. (eds) Cerebral Vasospasm. Acta Neurochirurgica Supplements, vol 77. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6232-3_5
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DOI: https://doi.org/10.1007/978-3-7091-6232-3_5
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-83650-7
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