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Deep Brain Stimulation of the Globus Pallidus Internus (GPI) for Torsion Dystonia — A Report of two Cases

  • Conference paper
Functional Rehabilitation in Neurosurgery and Neurotraumatology

Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 79))

Abstract

Generalized dystonia is known as a type of movement disorder in which pharmacotherapeutic options are very limited. Deep Brain Stimulation (DBS) is well established for Parkinson’s disease (PD) and tremor dominant movement disorders. We report on two cases of generalized dystonia which were successfully treated by chronic high frequency stimulation in the Globus pallidus internus (GPI).Two 26 and 27 years old males suffered from severe torsion dystonia and multisegmental dystonia of the lower limbs. Case 1 is a familiar type of dystonia (DYT1 positive). The onset of symptoms in both cases was at age 7. The complaints were initially treated with orally administered benzodiazepines, anticholinergic drugs, later by baclofen and L-DOPA. However there was no response. Case 2 was a patient with a history of left side dominated dystonia since the age of 8. It was first diagnozed as a psychogenic movement disorder. Prior to surgery he was treated with L-DOPA, anticholinergics, Baclofen without any effect. There was only a limited effect on high doses of diazepam. The patient is DYT1 negative.

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, University Medical Center Benjamin Franklin, Berlin, Germany

    J. Vesper, F. Stockhammer & M. Brock

  2. Department of Neurology, University Medical Center Benjamin Franklin, Berlin, Germany

    F. Klostermann

  3. Department of Neurosurgery, Klinikum Frankfurt, Frankfurt Oder, Germany

    Th. Funk

Authors
  1. J. Vesper
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  2. F. Klostermann
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  3. Th. Funk
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  4. F. Stockhammer
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  5. M. Brock
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Editors and Affiliations

  1. Clemens Hospital, München, Germany

    Klaus R. H. von Wild

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© 2002 Springer-Verlag Wien

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Vesper, J., Klostermann, F., Funk, T., Stockhammer, F., Brock, M. (2002). Deep Brain Stimulation of the Globus Pallidus Internus (GPI) for Torsion Dystonia — A Report of two Cases. In: von Wild, K.R.H. (eds) Functional Rehabilitation in Neurosurgery and Neurotraumatology. Acta Neurochirurgica Supplements, vol 79. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6105-0_19

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  • DOI: https://doi.org/10.1007/978-3-7091-6105-0_19

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7283-4

  • Online ISBN: 978-3-7091-6105-0

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