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Autophagy and Tumor Cell Metabolism

  • Chapter
Tumor Cell Metabolism

Abstract

Macroautophagy is a lysosomal degradative process for cellular components that is regulated by oncogenes and tumor suppressors. Macroautophagy plays a major role in cell homeostasis and in response to stress, where it acts as a cell survival mechanism. Indeed, during periods of starvation, stimulation of the autophagic pathway fuels cells with nutrients via lysosomal recycling to maintain metabolic activity and to respond to the demand for energy. The role of macroautophagy in cancer is complex and context dependent. Defective macroautophagy favors DNA damage and genomic instability, whereas normal macroautophagy protects cancer cells against metabolic stress by providing what is required to maintain metabolism in cancer cells. This chapter will describe the interplay between macroautophagy and metabolism and its regulation by metabolites, including those that control the posttranslational acetylation potential of proteins. The last part of the chapter will concern the role of autophagy in the maintenance and self-renewal of cancer stem cells.

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Acknowledgments

Work in P. Codogno’s laboratory is supported by institutional funding from the Institut National de la Santé et de la Recherche Medicale (INSERM) and grants from the Agence Nationale de la Recherche (ANR) and the Institut National du Cancer (INCa).

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Authors and Affiliations

  1. INSERM U1151, CNRS UMR 8253, Institut Necker Enfants-Malades, Université Paris 5 René Descartes, 14, rue Maria Helena Vieira Da Silva CS61431, 75993, Paris cedex 14, France

    Ahmed Hamaï, Joelle Botti, Maryam Mehrpour & Patrice Codogno

  2. Lariboisière-Saint Louis, Université Paris 7 Denis Diderot, 75010, Paris, France

    Joelle Botti

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  1. Ahmed Hamaï
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Correspondence to Patrice Codogno .

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  1. Inst. of Veterinary Physiology and Bioch, Justus-Liebig-University of Giessen, Gießen, Hessen, Germany

    Sybille Mazurek

  2. Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

    Maria Shoshan

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Hamaï, A., Botti, J., Mehrpour, M., Codogno, P. (2015). Autophagy and Tumor Cell Metabolism. In: Mazurek, S., Shoshan, M. (eds) Tumor Cell Metabolism. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1824-5_3

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