Skip to main content

Soil-Transmitted Helminths: The Neglected Parasites

  • Chapter
  • First Online:

Abstract

Soil-transmitted helminth (STH) infections are still considered to be the most prevalent infections of humankind. STH, traditionally endemic in rural areas, are increasingly becoming a public health concern in urban slums of cities in tropical and subtropical developing countries in Southeast Asia, sub-Saharan Africa and Central and South America. These helminths, Ascaris lumbricoides, hookworm (Ancylostoma duodenale and Necator americanus), Trichuris trichiura and Strongyloides stercoralis, can live in silence as chronic infections with prominent morbidity amongst children and mothers of childbearing age. The main impact of STH infections is their associations with malnutrition, vitamin A deficiency (VAD), iron-deficiency anaemia (IDA), intellectual retardation and cognitive and educational deficits. The devastating consequences of these helminths during childhood may continue into adulthood with effects on the economic productivity which trap the communities at risk of infections in a cycle of poverty, underdevelopment and disease. Hence, the WHO regarded the control of STH amongst the top five health priorities within the global massive effort to eradicate poverty. Moreover, controlling STH infections has significant positive impacts on the nutritional status and educational performance of the vulnerable children in endemic communities.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. P.J. Hotez et al., Rescuing the bottom billion through control of neglected tropical diseases. Lancet 373(9674), 1570–1575 (2009)

    PubMed  Google Scholar 

  2. R.L. Pullan, S.J. Brooker, The global limits and population at risk of soil-transmitted helminth infections in 2010. Parasit. Vectors 5, 81 (2012)

    PubMed Central  PubMed  Google Scholar 

  3. WHO, Preventive Chemotherapy in Human Helminthiasis. Coordinated Use of Anthelminthic Drugs in Control Interventions: A Manual for Health Professionals and Program Managers (World Health Organization, Geneva, 2006)

    Google Scholar 

  4. C.A. Acka et al., Parasitic worms: knowledge, attitudes, and practices in western Cote d’Ivoire with implications for integrated control. PLoS Negl. Trop. Dis. 4, e910 (2010)

    PubMed Central  PubMed  Google Scholar 

  5. L. Savioli et al., Progress in the prevention and control of schistosomiasis and soil-transmitted helminthiasis. Parasitol. Int. 53(2), 103–113 (2004)

    CAS  PubMed  Google Scholar 

  6. P.J. Hotez et al., New technologies for the control of human hookworm infection. Trends Parasitol. 22, 327–331 (2006)

    PubMed  Google Scholar 

  7. A. Ahmed et al., Soil-transmitted helminthiasis: a critical but neglected factor influencing school participation of Aboriginal children in rural Malaysia. Parasitology 139(6), 802–808 (2012)

    PubMed  Google Scholar 

  8. F.A. Neva, H.W. Brown, Basic Clinical Parasitology, 6th edn. (Prentice-Hall, London, 1995)

    Google Scholar 

  9. D.W.T. Crompton, Biology of Ascaris lumbricoides, in Ascariasis and Its Prevention and Control, ed. by D.W.T. Crompton, M.C. Nesheim, Z.S. Pawlowski (Taylor and Francis, London, 1989), pp. 9–44

    Google Scholar 

  10. J. Makidono, Observations on Ascaris during fluoroscopy. Am. J. Trop. Med. Hyg. 5, 699–702 (1956)

    CAS  PubMed  Google Scholar 

  11. P. Phanichyakaran et al., Loeffler’s syndrome report of two cases. Ramathibodi Med. J. 2, 147–151 (1979)

    Google Scholar 

  12. D.W.T. Crompton, Ascaris and ascariasis. Adv. Parasitol. 48, 285–375 (2001)

    CAS  PubMed  Google Scholar 

  13. E.S. Cooper, Epidemiology and transmission of intestinal helminths, in Enteric Infection 2. Intestinal Helminths, ed. by M.J.G. Farthing, G.T. Keusch, D. Wakelin (Chapman and Hall, London, 1995), pp. 201–212

    Google Scholar 

  14. P.J. Hotez, Human hookworm infection, in Enteric Infection 2. Intestinal Helminths, ed. by M.J.G. Farthing, G.T. Keusch, D. Wakelin (Chapman and Hall, London, 1995), pp. 129–150

    Google Scholar 

  15. J.K. Landmann, P. Prociv, Experimental human infection with the dog hookworm, Ancylostoma caninum. Med. J. Austr. 20, 67–69 (2003)

    Google Scholar 

  16. R. Malgor et al., High prevalence of Ancylostoma spp. infection in dogs, associated with endemic focus of human cutaneous larva migrans in Tacuarembo, Uruguay. Parasite 3, 131–134 (1996)

    CAS  PubMed  Google Scholar 

  17. B. Zhan et al., Molecular cloning and purification of Ac-TMP a developmentally regulated putative tissue inhibitor of metalloprotease released in relative abundance by adult Ancylostoma hookworms. Am. J. Trop. Med. Hyg. 66, 238–244 (2002)

    CAS  PubMed  Google Scholar 

  18. N.M. Beasley et al., The impact of weekly iron supplementation on the iron status and growth of adolescent girls in Tanzania. Trop. Med. Int. Health 5, 794–799 (2000)

    CAS  PubMed  Google Scholar 

  19. W.G. Smillie, D.L. Augustine, Hookworm infestation: the effect of varying intensities on the physical condition of school children. Am. J. Dis. Child. 31, 151–168 (1926)

    Google Scholar 

  20. D.A.P. Bundy, Epidemiology and transmission of intestinal helminths, in Enteric Infection 2. Intestinal Helminths, ed. by M.J.G. Farthing, G.T. Keusch, D. Wakelin (Chapman and Hall, London, 1995), pp. 5–24

    Google Scholar 

  21. M. Cheesbrough, District Laboratory Practice in Tropical Countries, 2nd edn. (Cambridge University press, Cambridge, 2004)

    Google Scholar 

  22. W. Ngrenngarmlert et al., Intestinal parasitic infections among school children in Thailand. Trop. Biomed. 24, 83–88 (2007)

    Google Scholar 

  23. S. Pinlaor et al., Detection of opportunistic and non-opportunistic intestinal parasites and liver flukes in HIV-positive and HIV-negative subjects. Southeast Asian J. Trop. Med. Public Health 36, 841–845 (2005)

    PubMed  Google Scholar 

  24. C. Sirivichayakul et al., Prevalence of intestinal parasitic infection among Thai people with mental handicaps. Southeast Asian J. Trop. Med. Public Health 34, 259–263 (2003)

    PubMed  Google Scholar 

  25. P. Phisalprapa, V. Prachayakul, Ascariasis as an unexpected cause of acute pancreatitis with cholangitis: a rare case report from urban area. JOP 14(1), 88–91 (2013)

    PubMed  Google Scholar 

  26. J. Waikagul et al., A cross-sectional study of intestinal parasitic infections among schoolchildren in Nan Province, Northern Thailand. Southeast Asian J. Trop. Med. Public Health 33, 218–223 (2002)

    CAS  PubMed  Google Scholar 

  27. M.T. Anantaphruti et al., Soil-transmitted helminthiases and health behaviors among schoolchildren and community members in a west-central border area of Thailand. Southeast Asian J. Trop. Med. Public Health 35, 260–266 (2004)

    PubMed  Google Scholar 

  28. V. Jiraanankul et al., Incidence and risk factors of hookworm infection in a rural community of central Thailand. Am. J. Trop. Med. Hyg. 84(4), 594–598 (2011)

    PubMed  Google Scholar 

  29. Anon, Review on the epidemiological profile of helminthiases of their control in the Western Pacific region, 1997–2008 (2008)

    Google Scholar 

  30. H.M. Al-Mekhlafi et al., Prevalence and distribution of soil-transmitted helminthiases among Orang Asli children in peripheral areas in Selangor, Malaysia. Southeast Asian J. Trop. Med. Public Health 37, 40–47 (2006)

    PubMed  Google Scholar 

  31. N.A. Nasr et al., Towards an effective control program of soil-transmitted helminth infections among Orang Asli in rural Malaysia. Part 1: Prevalence and associated key factors. Parasit. Vectors 6, 27 (2013)

    PubMed Central  PubMed  Google Scholar 

  32. R. Ngui et al., Prevalence and risk factors of intestinal parasitism in rural and remote West Malaysia. PLoS Negl. Trop. Dis. 5, e974 (2011)

    PubMed Central  PubMed  Google Scholar 

  33. M. Norhayati et al., The prevalence of Trichuris, Ascaris and hookworm infection in Orang Asli children. Southeast Asian J. Trop. Med. Public Health 8, 161–168 (1997)

    Google Scholar 

  34. S.P. Kan, Soil transmitted helminthiases in Selangor, Malaysia. Med. J. Malaysia 92, 263–269 (1989)

    CAS  Google Scholar 

  35. K. Hanjeet et al., Soil-transmitted helminthiases in squatter populations around Kuala Lumpur by ethnic distribution. Trop. Biomed. 8, 33–37 (1991)

    Google Scholar 

  36. L.B. Huat et al., Prevalence and risk factors of intestinal helminth infection among rural children. J. Glob. Infect. Dis. 4(1), 10–14 (2012)

    PubMed Central  PubMed  Google Scholar 

  37. A. Zulkifli et al., The prevalence of malnutrition and geo-helminth infections among primary schoolchildren in rural Kelantan. Southeast Asian J. Trop. Med. Public Health 31, 339–345 (2000)

    CAS  PubMed  Google Scholar 

  38. H.M. Al-Mekhlafi et al., Pattern and predictors of soil-transmitted helminth reinfection among aboriginal schoolchildren in rural Peninsular Malaysia. Acta Trop. 107, 200–204 (2008)

    Google Scholar 

  39. M. Basuni et al., A pentaplex real-time polymerase chain reaction assay for detection of four species of soil-transmitted helminths. Am. J. Trop. Med. Hyg. 84(2), 338–343 (2011)

    PubMed  Google Scholar 

  40. R. Ngui et al., Rapid detection and identification of human hookworm infections through high resolution melting (HRM) analysis. PLoS One 7(7), e41996 (2012)

    CAS  PubMed Central  PubMed  Google Scholar 

  41. R. Ngui et al., Epidemiological and genetic data supporting the transmission of Ancylostoma ceylanicum among human and domestic animals. PLoS Negl. Trop. Dis. 6(2), e1522 (2012)

    PubMed Central  PubMed  Google Scholar 

  42. M.A. Mahdy et al., Prevalence and zoonotic potential of canine hookworms in Malaysia. Parasit. Vectors 5, 88 (2012)

    PubMed Central  PubMed  Google Scholar 

  43. M.N. Mahmud, Intestinal obstruction due to ascariasis in children [Abstract], in The 51th General Scientific Meeting, Royal Australian College of Surgeons, Kuala Lumpur, 1973

    Google Scholar 

  44. H.M. Al-Mekhlafi et al., Prevalence and predictors of low serum retinol and hypoalbuminaemia among children in rural Peninsular Malaysia. Trans. R. Soc. Trop. Med. Hyg. 101, 1233–1240 (2007)

    PubMed  Google Scholar 

  45. H.M. Al-Mekhlafi et al., Malnutrition and soil-transmitted helminthiasis among Orang Asli children in Selangor, Malaysia. Asia Pac. J. Clin. Nutr. 14, 188–194 (2005)

    PubMed  Google Scholar 

  46. U. Nor Aini et al., Serum iron status in Orang Asli children living in endemic areas of soil-transmitted helminths. Asia Pac. J. Clin. Nutr. 16, 724–730 (2007)

    PubMed  Google Scholar 

  47. M. Norhayati et al., Intestinal parasitic infection in man: a review. Med. J. Malaysia 58, 296–305 (2003)

    CAS  PubMed  Google Scholar 

  48. N.M. Azira, M. Zeehaida, Strongyloides stercoralis hyperinfection in a diabetic patient: case report. Trop. Biomed. 27(1), 115–119 (2010)

    CAS  PubMed  Google Scholar 

  49. M.Z. Abdelrahman et al., Fatal septicemic shock associated with Strongyloides stercoralis infection in a patient with angioimmunoblastic T-cell lymphoma: a case report and literature review. Parasitol. Int. 61(3), 508–511 (2012)

    CAS  PubMed  Google Scholar 

  50. M. Zeehaida et al., Strongyloides stercoralis in common vegetables and herbs in Kota Bharu, Kelantan, Malaysia. Trop. Biomed. 28(1), 188–193 (2011)

    CAS  PubMed  Google Scholar 

  51. A.F. Ahmad et al., Serological and molecular detection of Strongyloides stercoralis infection among an Orang Asli community in Malaysia. Parasitol. Res. 112(8), 2811–2816 (2013)

    PubMed  Google Scholar 

  52. V.Y. Belizario Jr. et al., Sentinel surveillance of soil-transmitted helminthiasis in selected local government units in the Philippines. Asia Pac. J. Public Health 21, 26–42 (2009)

    PubMed  Google Scholar 

  53. V.Y. Belizario Jr. et al., Soil-transmitted helminth and other intestinal parasitic infections among school children in indigenous people communities in Davao del Norte, Philippines. Acta Trop. 120(Suppl 1), S12–S18 (2011)

    PubMed  Google Scholar 

  54. Anon, Soil-transmitted helminthiasis: number of children treated 2007–2008: update on the 2010 global target. Wkly. Epidemiol. Rec. 85, 141–148 (2010)

    Google Scholar 

  55. P. Hadidjaja et al., The effect of intervention methods on nutritional status and cognitive function of primary school children infected with Ascaris lumbricoides. Am. J. Trop. Med. Hyg. 59(5), 791–795 (1998)

    CAS  PubMed  Google Scholar 

  56. S.S. Margono, Important human helminthiasis in Indonesia, in Controlling Disease due to Helminth Infections, ed. by D.W.T. Crompton, A. Montresor, M.C. Nesheim, L. Savioli (World Health Organization, Geneva, 2003), pp. 3–14

    Google Scholar 

  57. D.P. Widjana, P. Sutisna, Prevalence of soil-transmitted helminth infections in the rural population of Bali, Indonesia. Southeast Asian J. Trop. Med. Public Health 31, 454–459 (2000)

    CAS  PubMed  Google Scholar 

  58. A. Sasongko et al., Practical experience from the primary school-based soil-transmitted helminth control programme in Jakarta (1978-1999), in Controlling Disease due to Helminth Infections, ed. by D.W.T. Crompton, A. Montresor, M.C. Nesheim, L. Savioli (World Health Organization, Geneva, 2003), p. 225

    Google Scholar 

  59. Satoto et al., Partnership for child development: an international programme to improve the health of school-age children by school-based health of school-age children by school-based health services including deworming, in Controlling Disease Due to Helminth Infections, ed. by D.W.T. Crompton, A. Montresor, M.C. Nesheim, L. Savioli (World Health Organization, Geneva, 2003), pp. 93–98

    Google Scholar 

  60. I.N. Lubis et al., Current status of the efficacy and effectiveness of albendazole and mebendazole for the treatment of Ascaris lumbricoides in North-Western Indonesia. Asian Pac. J. Trop. Med. 5(8), 605–609 (2012)

    CAS  PubMed  Google Scholar 

  61. M.J. Bangs et al., Strongyloidiasis with gastric mucosal invasion presenting with acute interstitial nephritis. Southeast Asian J. Trop. Med. Public Health 37(4), 641–647 (2006)

    Google Scholar 

  62. T.T. Do et al., Helminth infections among people using wastewater and human excreta in peri-urban agriculture and aquaculture in Hanoi, Vietnam. Trop. Med. Int. Health 12(Suppl 2), 82–90 (2007)

    PubMed  Google Scholar 

  63. A. Montresor et al., Cost containment in a school deworming programme targeting over 2.7 million children in Vietnam. Trans. R. Soc. Trop. Med. Hyg. 101, 461–464 (2007)

    PubMed  Google Scholar 

  64. T. Trang do et al., Low risk for helminth infection in wastewater-fed rice cultivation in Vietnam. J. Water Health 4, 321–331 (2006)

    PubMed  Google Scholar 

  65. S. Uga et al., Intestinal parasitic infections in schoolchildren in a suburban area of Hanoi, Vietnam. Southeast Asian J. Trop. Med. Public Health 36, 1407–1411 (2005)

    PubMed  Google Scholar 

  66. P. Verle et al., Prevalence of intestinal parasitic infections in northern Vietnam. Trop. Med. Int. Health 8, 961–964 (2003)

    CAS  PubMed  Google Scholar 

  67. A. Yajima et al., High latrine coverage is not reducing the prevalence of soil-transmitted helminthiasis in Hoa Binh province, Vietnam. Trans. R. Soc. Trop. Med. Hyg. 103, 237–241 (2009)

    PubMed  Google Scholar 

  68. P. Pham-Duc et al., Ascaris lumbricoides and Trichuris trichiura infections associated with wastewater and human excreta use in agriculture in Vietnam. Parasitol. Int. 62(2), 172–180 (2013)

    PubMed  Google Scholar 

  69. H.T. Le et al., Anemia and intestinal parasite infection in school children in rural Vietnam. Asia Pac. J. Clin. Nutr. 16, 716–723 (2007)

    CAS  PubMed  Google Scholar 

  70. P.H. Nguyen et al., Intestinal helminth infections among reproductive age women in Vietnam: prevalence, co-infection and risk factors. Southeast Asian J. Trop. Med. Public Health 37, 865–874 (2006)

    PubMed  Google Scholar 

  71. W. van der Hoek et al., Current status of soil-transmitted helminths in Vietnam. Southeast Asian J. Trop. Med. Public Health 34(Suppl 1), 1–11 (2003)

    PubMed  Google Scholar 

  72. A. Montresor et al., Large-scale preventive chemotherapy for the control of helminth infection in Western Pacific countries: six years later. PLoS Negl. Trop. Dis. 2(8), e278 (2008)

    PubMed Central  PubMed  Google Scholar 

  73. M. Sinuon et al., Control of Schistosoma mekongi in Cambodia: results of eight years of control activities in the two endemic provinces. Trans. R. Soc. Trop. Med. Hyg. 101, 34–39 (2007)

    CAS  PubMed  Google Scholar 

  74. C.E. Moore et al., Changing patterns of gastrointestinal parasite infections in Cambodian children: 2006-2011. J. Trop. Pediatr. 58(6), 509–512 (2012)

    PubMed  Google Scholar 

  75. V. Khieu et al., Diagnosis, treatment and risk factors of Strongyloides stercoralis in schoolchildren in Cambodia. PLoS Negl. Trop. Dis. 7(2), e2035 (2013)

    CAS  PubMed Central  PubMed  Google Scholar 

  76. F. Schär et al., Evaluation of real-time PCR for Strongyloides stercoralis and hookworm as diagnostic tool in asymptomatic schoolchildren in Cambodia. Acta Trop. 126(2), 89–92 (2013)

    PubMed  Google Scholar 

  77. H.J. Rim et al., Prevalence of intestinal parasite infections on a national scale among primary schoolchildren in Laos. Parasitol. Res. 91, 267–272 (2003)

    PubMed  Google Scholar 

  78. B. Phommasack et al., Coverage and costs of a school deworming programme in 2007 targeting all primary schools in Lao PDR. Trans. R. Soc. Trop. Med. Hyg. 102, 1201–1206 (2008)

    PubMed  Google Scholar 

  79. S. Sayasone et al., Diversity of human intestinal helminthiasis in Lao PDR. Trans. R. Soc. Trop. Med. Hyg. 103, 247–254 (2009)

    PubMed  Google Scholar 

  80. S. Kounnavong et al., Trans. R. Soc. Trop. Med. Hyg. 105, 160–166 (2011)

    PubMed  Google Scholar 

  81. M. Sato et al., Short report: human Trichostrongylus colubriformis infection in a rural village in Laos. Am. J. Trop. Med. Hyg. 84(1), 52–54 (2011)

    PubMed  Google Scholar 

  82. J.V. Conlan et al., Soil-transmitted helminthiasis in Laos: a community-wide cross-sectional study of humans and dogs in a mass drug administration environment. Am. J. Trop. Med. Hyg. 86(4), 624–634 (2012)

    PubMed  Google Scholar 

  83. Thein-Hlaing, A profile of ascariasis morbidity in Rangoon children’s Hospital Burma. J. Trop. Med. 90, 165–169 (1987)

    Google Scholar 

  84. Thein-Hlaing et al., Role of ascariasis in surgical abdominal emergencies in the Rangoon Children’s Hospital, Burma. Ann. Trop. Paediatr. 10, 53–60 (1990)

    Google Scholar 

  85. A. Montresor et al., Soil-transmitted helminthiasis in Myanmar and approximate costs for countrywide control. Trop. Med. Int. Health 9, 1012–1015 (2004)

    PubMed  Google Scholar 

  86. WHO, Soil-transmitted helminthiases. Eliminating soil-transmitted helminthiases as a public health problem in children: Progress Report 2001-2010 and Strategic Plan 2011-2020 (World Health Organisation, Geneva, 2012)

    Google Scholar 

  87. G.J. Casey et al., Elimination of iron deficiency anemia and soil transmitted helminth infection: evidence from a fifty-four month iron-folic acid and de-worming program. PLoS Negl. Trop. Dis. 7(4), e2146 (2013)

    CAS  PubMed Central  PubMed  Google Scholar 

  88. S.A. Tanumihardjo et al., Vitamin A status and hemoglobin concentrations are improved in Indonesian children with vitamin A and deworming interventions. Eur. J. Clin. Nutr. 58(9), 1223–1230 (2004)

    Google Scholar 

  89. H. Bleakley, Disease and development: evidence from hookworm eradication in the American South. Q. J. Econom. 122, 73–117 (2007)

    Google Scholar 

  90. L. Conteh et al., Socioeconomic aspects of neglected tropical diseases. Lancet 375, 239–247 (2010)

    PubMed  Google Scholar 

  91. L.S. Stephenson et al., Improvements in physical fitness of Kenyan schoolboys infected with hookworm, Trichuris trichiura and Ascaris lumbricoides following a single dose of albendazole. Trans. R. Soc. Trop. Med. Hyg. 84, 277–282 (1990)

    CAS  PubMed  Google Scholar 

  92. E.A. Miguel, M. Kremer, Worms: identifying impacts on education and health in the presence of treatment externalities. Econometrica 72(1), 159–217 (2003)

    Google Scholar 

  93. D.A.P. Bundy et al., Deworming and development: asking the right questions, asking the questions right. PLoS Negl. Trop. Dis. 3(1), e362 (2009)

    PubMed Central  PubMed  Google Scholar 

  94. N. Ohta, J. Waikagul, Disease burden and epidemiology of soil-transmitted helminthiases and schistosomiasis in Asia: the Japanese perspective. Trends Parasitol. 23, 30–35 (2007)

    PubMed  Google Scholar 

  95. C. Urbani, M. Albonico, Anthelminthic drug safety and drug administration in the control of soil-transmitted helminthiasis in community campaigns. Acta Trop. 86(2–3), 215–221 (2003)

    PubMed  Google Scholar 

  96. WHO, Deworming for health and development. Report of the third global meeting of the partners for parasite control (World Health Organization, Geneva, 2005)

    Google Scholar 

  97. WHO, Prevention and Control of intestinal parasitic infections: Prevention and control of schistosomiasis and soil-transmitted helminthiasis. Technical Report Series No. 912. World Health Organisation, Geneva, 2002

    Google Scholar 

  98. S. Sow et al., Hygiene practices and contamination risks of surface waters by schistosome eggs: the case of an infested village in Northern Senegal. Bull. Soc. Pathol. Exot. 7, 12–14 (2004)

    Google Scholar 

  99. Y.A.L. Lim et al., Intestinal parasitic infections amongst Orang Asli (indigenous) in Malaysia: has socioeconomic development alleviated the problem? Trop. Biomed. 26, 110–122 (2009)

    CAS  PubMed  Google Scholar 

  100. T.V. Luong, De-worming school children and hygiene intervention. Int. J. Environ. Health Res. 13, S153–S159 (2003)

    PubMed  Google Scholar 

  101. Y.C.F. Lumampao, L.C. David, Community-managed control of soil-transmitted helminthiasis in the Philippines, in Controlling Disease due to Helminth Infections, ed. by D.W.T. Crompton, A. Montresor, M.C. Nesheim, L. Savioli (World Health Organization, Geneva, 2003), p. 183

    Google Scholar 

  102. A. Ehrhardt et al., Evaluation of coverage of deworming interventions in Vietnam. Southeast Asian J. Trop. Med. Public Health 37, 1091–1094 (2006)

    CAS  PubMed  Google Scholar 

  103. M. Sinuon et al., Financial costs of deworming children in all primary schools in Cambodia. Trans. R. Soc. Trop. Med. Hyg. 99, 664–668 (2005)

    PubMed  Google Scholar 

  104. C. Urbani, K. Palmer, Drug-based helminth control in Western Pacific countries: a general perspective. Trop. Med. Int. Health 6, 935–944 (2001)

    CAS  PubMed  Google Scholar 

  105. E.A. Padmasiri et al., Controlling lymphatic filariasis and soil-transmitted helminthiasis together in South Asia: opportunities and challenges. Trans. R. Soc. Trop. Med. Hyg. 100, 807–810 (2006)

    CAS  PubMed  Google Scholar 

  106. A.R. Jex et al., Soil-transmitted helminths of humans in Southeast Asia – towards integrated control. Adv. Parasitol. 74, 231–265 (2011)

    PubMed  Google Scholar 

  107. L.M. Mascarini-Serra et al., Reductions in the prevalence and incidence of geohelminth infections following a city-wide sanitation program in a Brazilian Urban Centre. PLoS Negl. Trop. Dis. 4(2), e-588 (2010)

    Google Scholar 

  108. WHO/UNICEF, How to Add Deworming to Vitamin A Distribution (World Health Organization/The United Nations Children’s Fund, Geneva, 2004)

    Google Scholar 

  109. A. Datry et al., Treatment of Strongyloides stercoralis infection with ivermectin compared with albendazole: results of an open study of 60 cases. Trans. R. Soc. Trop. Med. Hyg. 88, 344–345 (1994)

    CAS  PubMed  Google Scholar 

  110. N. de Silva et al., Anthelmintics: a comparative review of their clinical pharmacology. Drugs 53, 769–788 (1997)

    PubMed  Google Scholar 

  111. WHO, Health of School children. Treatment Intestinal Helminths and Schistosomiasis (World Health Organisation, Geneva, 1995)

    Google Scholar 

  112. J. Bethony et al., Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. Lancet 367, 1521–1532 (2006)

    PubMed  Google Scholar 

  113. E. Lacey, Mode of action of benzimidazoles. Parasitol. Today 6, 112–115 (1990)

    CAS  PubMed  Google Scholar 

  114. C. Sirivichayakul et al., A comparative trial of albendazole alone versus combination of albendazole and praziquantel for treatment of Trichuris trichiura infection. Southeast Asian J. Trop. Med. Public Health 32(2), 297–301 (2001)

    CAS  PubMed  Google Scholar 

  115. WHO, The Millennium Development Goals Report 2011 (World Health Organisation, Geneva, 2011)

    Google Scholar 

  116. R.G. Feachem et al., Sanitation and Disease: Health Aspects of Waste Water and Excreta Management (Wiley, Chichester, 1983)

    Google Scholar 

  117. S.O. Asaolu, I.E. Ofoezie, The role of health education and sanitation in the control of helminth infections. Acta Trop. 86, 283–294 (2003)

    CAS  PubMed  Google Scholar 

  118. A. Ahmed et al., The burden of moderate-to-heavy soil-transmitted helminth infections among rural Malaysian aborigines: an urgent need for an integrated control program. Parasit. Vectors 4, 242 (2011)

    PubMed Central  PubMed  Google Scholar 

  119. V. Chongsuvivatwong et al., Predictors for the risk of hookworm infection: experience from endemic villages in southern Thailand. Trans. R. Soc. Trop. Med. Hyg. 90(6), 630–633 (1996)

    CAS  PubMed  Google Scholar 

  120. T.E. Erlanger et al., Baseline health situation of communities affected by the Nam Theun 2 hydroelectric project in central Lao PDR and indicators for monitoring. Int. J. Environ. Health Res. 18(3), 223–242 (2008)

    PubMed  Google Scholar 

  121. K. Gunawardena et al., Soil-transmitted helminth infections among plantation sector schoolchildren in Sri Lanka: prevalence after ten years of preventive chemotherapy. PLoS Negl. Trop. Dis. 5(9), e1341 (2011)

    PubMed Central  PubMed  Google Scholar 

  122. A. Toma et al., Questionnaire survey and prevalence of intestinal helminthic infections in Barru, Sulawesi, Indonesia. Southeast Asian J. Trop. Med. Public Health 30, 68–77 (1999)

    CAS  PubMed  Google Scholar 

  123. D.T. Trang et al., Helminth infections among people using wastewater and human excreta in peri-urban agriculture and aquaculture in Hanoi, Vietnam. Trop. Med. Int. Health 12, 82–90 (2007)

    Google Scholar 

  124. K. Ziegelbauer et al., Effect of sanitation on soil-transmitted helminth infection: systematic and meta-analysis. PLoS Med. 9(1), e1001162 (2012)

    PubMed Central  PubMed  Google Scholar 

  125. H.E. Ekeh, J.D. Adeniyi, Health education strategies for tropical disease control in school children. J. Trop. Med. Hyg. 91(2), 55–59 (1988)

    CAS  PubMed  Google Scholar 

  126. J. Keiser, J. Utzinger, Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis. JAMA 299(16), 1937–1948 (2008)

    CAS  PubMed  Google Scholar 

  127. D. Mara et al., Sanitation and health. PLoS Med. 7(11), e1000363 (2010)

    PubMed Central  PubMed  Google Scholar 

  128. M. Albonico et al., The control of intestinal parasitic infections in the Seychelles: a comprehensive and sustainable approach. Bull. World Health Organ. 74, 577–586 (1996)

    CAS  PubMed Central  PubMed  Google Scholar 

  129. S.A. Esrey et al., Effects of improved water supply and sanitation on ascariasis, diarrhoea, dracunculiasis, hookworm infection, schistosomiasis, and trachoma. Bull. World Health Organ. 69, 609–621 (1991)

    CAS  PubMed Central  PubMed  Google Scholar 

  130. A. Kobayashi et al., Historical aspects for the control of soil-transmitted helminthiases. Parasitol. Int. 55, S289–S291 (2006)

    PubMed  Google Scholar 

  131. S.T. Hong et al., A successful experience of soil-transmitted helminths control in the Republic of Korea. Korean J. Parasitol. 44, 177–185 (2006)

    PubMed Central  PubMed  Google Scholar 

  132. S. Kojima, et al., School-health-based parasite control initiatives: extending successful Japanese policies to Asia and Africa. Trends Parasitol. 23(2), 54–57 (2007)

    PubMed  Google Scholar 

  133. Children without Worms, Antonio Montresor: reflecting on Cambodia’s successful STH control (2011), http://www.childrenwithoutworms.org/quarterly-dose-articles/antonio-montresor-cambodias-sth-control

  134. R.J. Aaron et al., Soil-transmitted helminths of humans in Southeast Asia towards integrated control. Adv. Parasitol. 74, 231–265 (2011)

    Google Scholar 

  135. M.S. Chan et al., Transmission patterns and the epidemiology of hookworm infection. Int. J. Epidemiol. 26, 1392–1400 (1997)

    CAS  PubMed  Google Scholar 

  136. M. Albonico et al., Rate of reinfection with intestinal nematodes after treatment of children with mebendazole or albendazole in a highly endemic area. Trans. R. Soc. Trop. Med. Hyg. 89, 538–541 (1995)

    CAS  PubMed  Google Scholar 

  137. M. Albonico et al., Efficacy of mebendazole and levamisole alone or in combination against intestinal nematode infections after repeated targeted mebendazole treatment in Zanzibar. Bull. World Health Organ. 81, 343–352 (2003)

    CAS  PubMed Central  PubMed  Google Scholar 

  138. R.M. Kaplan, Drug resistance in nematodes of veterinary importance: a status report. Trends Parasitol. 20(10), 477–481 (2004)

    CAS  PubMed  Google Scholar 

  139. E. Devaney, The end of the line for hookworm? An update on vaccine development. PLoS Med. 2(10), e327 (2005)

    PubMed Central  PubMed  Google Scholar 

  140. J. Bethony et al., Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals. FASEB J. 19, 1743–1745 (2005)

    CAS  PubMed  Google Scholar 

  141. P.J. Hotez et al., Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malaria. PLoS Med. 3(5), e102 (2006)

    PubMed Central  PubMed  Google Scholar 

  142. D.J. Diemert et al., Generalized urticaria induced by the Na-ASP-2 hookworm vaccine: implications for the development of vaccines against helminths. J. Allergy Clin. Immunol. 130, 169–176 (2012)

    CAS  PubMed  Google Scholar 

  143. Anon, Clinical trials for first-ever human hookworm vaccine advance (2012). Sabin Institute Press Release, 5 Nov 2012

    Google Scholar 

  144. G.N. Goud et al., Expression, purification, and molecular analysis of the Necator americanus glutathione S-transferase 1 (Na-GST-1): a production process developed for a lead candidate recombinant hookworm vaccine antigen. Protein Expr. Purif. 83, 145–151 (2012)

    CAS  PubMed  Google Scholar 

  145. A.R. Jariwala et al., Potency testing for the experimental Na-GST-1 hookworm vaccine. Expert Rev. Vaccines 9, 1219–1230 (2010)

    CAS  PubMed  Google Scholar 

  146. A.L. Williamson et al., Cleavage of hemoglobin by hookworm cathepsin D aspartic proteases and its potential contribution to host specificity. FASEB J. 11, 1458–1460 (2002)

    Google Scholar 

  147. S. Brooker, E. Michael, The potential of geographical information systems and remote sensing in the epidemiology and control of human helminth infections. Adv. Parasitol. 47, 245–287 (2000)

    CAS  PubMed  Google Scholar 

  148. S. Brooker et al., Global epidemiology, ecology and control of soil-transmitted helminth infections. Adv. Parasitol. 62, 221–261 (2006)

    CAS  PubMed Central  PubMed  Google Scholar 

  149. S.I. Hay, An overview of remote sensing and geodesy for epidemiology and public health applications. Adv. Parasitol. 47, 2–27 (2000)

    Google Scholar 

  150. F.L. Dunn, Intestinal parasitism in Malayan aborigines (Orang Asli). Bull. World Health Organ. 46, 99–113 (1972)

    CAS  PubMed Central  PubMed  Google Scholar 

  151. V. Hadju et al., Effectiveness of deworming in schoolchildren through school feeding in Indonesia, in Controlling Diseases due to Helminth Infections, ed. by D.W. Crompton, A. Montresor, M.C. Nesheim, L. Savioli (World Health Organization, Geneva, 2003), pp. 211–223

    Google Scholar 

  152. S. Brooker et al., Use of remote sensing and a geographical information system in a national helminth control program in Chad. Bull. World Health Organ. 80, 783–789 (2002)

    PubMed Central  PubMed  Google Scholar 

  153. S. Brooker et al., Using NOAA-AVHRR data to model helminth distributions for planning disease control in Cameroon, West Africa. Photogramm. Eng. Remote Sensing 68, 175–179 (2002)

    Google Scholar 

  154. S. Brooker et al., An updated atlas of human helminth infections: the example of East Africa. Int. J. Health Geogr. 8, 42 (2009)

    PubMed Central  PubMed  Google Scholar 

  155. S. Brooker et al., Towards an atlas of human helminth infection in sub-Saharan Africa: the use of geographical information systems (GIS). Parasitol. Today 16, 303–307 (2000)

    CAS  PubMed  Google Scholar 

  156. S. Brooker et al., Mapping soil-transmitted helminths in Southeast Asia and implications for parasite control. Southeast Asian J. Trop. Med. Public Health 34, 24–36 (2003)

    CAS  PubMed  Google Scholar 

  157. S. Knopp et al., Spatial distribution of soil-transmitted helminths, including Strongyloides stercoralis, among children in Zanzibar. Geospat. Health 3, 47–56 (2008)

    PubMed  Google Scholar 

  158. R.L. Pullan et al., Spatial modelling of soil-transmitted helminth infections in Kenya: a disease control planning tool. PLoS Negl. Trop. Dis. 5, 2 (2011)

    Google Scholar 

  159. L.A. Tchuem Tchuente et al., Mapping of schistosomiasis and soil-transmitted helminthiasis in the regions of centre, east and west Cameroon. PLoS Negl. Trop. Dis. 6, 3 (2012)

    Google Scholar 

  160. Brooker S, Human helminth infections in Indonesia, East Timor and the Philippines. Report to UNICEF East Asia and Pacific Region Bangkok, Thailand, 2002

    Google Scholar 

  161. Anon, FRESH: Focusing Resources on Education and School Health. A FRESH start to improving the quality and equity of education. UNESCO, UNICEF, WHO and World Bank, Washington, DC, 2000

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Hesham M. Al-Mekhlafi or Yvonne A. L. Lim .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Wien

About this chapter

Cite this chapter

Al-Mekhlafi, H.M., Lim, Y.A.L., Moktar, N., Ngui, R. (2013). Soil-Transmitted Helminths: The Neglected Parasites. In: Lim, Y., Vythilingam, I. (eds) Parasites and their vectors. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1553-4_11

Download citation

Publish with us

Policies and ethics