Zusammenfassung
Klinische Daten zu Verlauf und Prognose der CED bei Älteren liegen nur wenige vor, wenngleich bis zu 35 % des Gesamtkollektivs von CED-Patienten älter als 60 Jahre sind. Der Zeitraum zwischen Beginn der Symptomatik und Diagnosestellung ist üblicherweise länger, Fehldiagnosen sind häufig in Anbetracht der vielen Differenzialdiagnosen beim alten Menschen. In den meisten klinischen Studien werden ältere CED Patienten entweder unzureichend oder überhaupt nicht abgebildet, dabei sind Diagnostik und Therapie in dieser Lebensphase durch eine Vielzahl von Faktoren wie veränderte Pharmakokinetik, eingeschränkte Nierenfunktion, häufige Komorbiditäten und die allfällige Polypharmazie erschwert. Im nachfolgenden Kapitel sollen die für den klinischen Alltag relevanten Besonderheiten in der Diagnostik und Therapie älterer Patienten mit CED dargestellt werden.
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Literatur
Ananthakrishnan AN, Donaldson T, Lasch K (2017) Management of inflammatory bowel disease in the elderly patient: challenges and opportunities. Inflamm Bowel Dis 23(6):882–893
Arnott I, Rogler G, Halfvarson J (2017) The management of inflammatory bowel disease in elderly: current evidence and future perspectives. Inflamm Intest Dis 2:189–199
Beaugerie L (2013) Lymphoma: The Bête Noire of the long-term use of thiopurines in adult and elderly patients with inflammatory bowel disease. Gastroenterology 145:927–930
Biagi E, Candela M, Fairweather-Tait S et al (2012) Ageing of the human metaorganism: the microbial counterpart. Age 34:247–267
Bollegala N, Jackson TD, Nguyen GC (2016) Increased postoperative mortality and complications among elderly patients with inflammatory bowel diseases: an analysis of the National Surgical Quality Improvement Program Cohort. Clin Gastroenterol Hepatol 14:1274–1281
Brassard P, Bitton A, Suissa A et al (2014) Oral corticosteroids and the risk of serious infections in patients with elderly-onset inflammatory bowel disease. Am J Gastroenterol 109:1795–1802
Burr NE, Lord R, Hull MA, Subramanian V (2019) Decreasing risk of first and subsequent surgeries in patients with Crohn’s disease in England from 1994 through 2013. Clin Gastroenterol Hepatol. https://doi.org/10.1016/j.cgh.2018.12.022
Calafat M, Manosa M, Canete F et al (2018) The initiation of thiopurines in elderly patients with inflammatory bowel disease is associated with an increased risk of adverse effects: a case-control study of the ENEIDA registry. J Crohns Colitis 12(1):023–025
Chaparro M, Ordas I, Cabre E et al (2013) Safety of thiopurine therapy in inflammatory bowel disease: long-term follow-up study of 3931 patients. Inflamm Bowel Dis 19:1404–1410
Charpentier C, Salleron J, Savoye G et al (2014) Natural history of elderly onset inflammatory bowel disease: a population-based cohort study. Gut 63:423–432
Cottone M, Kohn A, Daperno M et al (2011) Advanced age is an independent risk factor for severe infections and mortality in patients given anti-tumor necrosis factor therapy for inflammatory bowel disease. Clin Gastroenterol Hepatol 9:30–35
Curtis JR, Schulze-Koops H, Takiya L et al (2017) Efficacy and safety of tofacitinib in older and younger patients with rheumatoid arthritis. Clin Exp Rheumatol 35:390–400
Everhov AH, Halfvarson J, Myrelid P et al (2018) Incidence and treatment of patients diagnosed with inflammatory bowel disease at 60 years or older in Sweden. Gastroenterology 154:518–528
Fries W, Viola A, Manetti N et al (2017) Disease patterns in late onset ulcerative colitis: results from the IG-IBD „AGED study“. Dig Liver Dis 49:17–23
Jeuring SF, van den Heuvel TR, Zeegers MP et al (2016) Epidemiology and longterm outcome of inflammatory bowel disease diagnosed at elderly age – an increasing distinct entity? Inflamm Bowel Dis 22:1425–1434
Kaplan GG, Ng SC (2017) Understanding and preventing the global increase of inflammatory bowel disease. Gastroenterology 152:313–321
Katz S, Pardi DS (2011) Inflammatory bowel disease of the elderly: frequently asked questions (FAQs). Am J Gastroenterol 106:1889–1897
Kedia S, Limdi JK, Ahuja V (2018) Management of inflammatory bowel disease in older persons: evolving paradigms. Intest Res 16(2):194–208
Khan N, Abbas AM, Lichtenstein GR et al (2013) Risk of lymphoma in patients with ulcerative colitis treated with thiopurines: a nationwide retrospective cohort study. Gastroenterology 145:1007–1015
Kirchgesner J, Lemaitre M, Carrat F et al (2018) Risk of serious and opportunistic infections associated with treatment of inflammatory bowel diseases. Gastroenterology. 155:337–346
Lakatos PL, David G, Pandur T et al (2011) IBD in the elderly population: results from a population-based study in Western Hungary, 1977–2008. J Crohns Colitis 5:5–13
Lichtenstein GR, Feagan BG, Cohen RD et al (2018) Infliximab for Crohn’s disease: more than 13 years of real-world experience. Inflamm Bowel Dis 24:490–501
Lobaton T, Ferrante M, Rutgeerts P et al (2015) Efficacy and safety of anti-TNF therapy in elderly patients with inflammatory bowel disease. Aliment Pharmacol Ther 42:441–451
Lynn AM, Loftus EV (2018) Illuminating the Black Box: The Real Risk of Serious Infection With Inflammatory Bowel Disease Therapies. Gastroenterology 155:262–265
Rahier JF, Magro F, Abreu C et al (2014) Second European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease. J Crohns Colitis 8:443–468
Ruel J, Ruane D, Mehandru S et al (2014) IBD across the age spectrum – is it the same disease? Nat Rev Gastroenterol Hepatol 11:88–98
Sato S et al (2015) Mucosal immunosenescence in the gastrointestinal tract. Gerontology 61:336–342
Song EM, Lee HS, Park SH et al (2018) Clinical characteristics and long-term prognosis of elderly-onset ulcerative colitis. J Gastroenterol Hepatol 33:172–179
Sturm A, Maaser Ch, Mendall M et al (2017) European Crohn’s and colitis organisation topical review on IBD in the elderly. J Crohns Colitis 11:263–273
Subramaniam K, D’Rozario J, Pavli P (2013) Lymphoma and other lymphoproliferative disorders in inflammatory bowel disease: a review. J Gastroenterol Hepatol 28:24–30
Tan VP, Chung A, Yan BP, Gibson PR (2013) Venous and arterial disease in inflammatory bowel disease. J Gastroenterol Hepatol 28:1095–1113
Tilg H, Moschen AR, Kaser A, Pines A, Dotan I (2008) Gut, inflammation and osteoporosis: basic and clinical concepts. Gut 57:684–694
Tran AH, Man Ngor EW, Wu BU (2014) Surveillance colonoscopy in elderly patients: a retrospective cohort study. JAMA 174:1675–1682
Yajnik V, Khan N, Dubinsky M et al (2017) Efficacy and safety of vedolizumab in ulcerative colitis and Crohn’s disease patients stratified by age. Adv Ther 34:542–559
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Hartmann, F. (2020). CED im höheren Lebensalter. In: Hoffmann, J.C., Klump, B., Kroesen, A., Siegmund, B. (eds) Chronisch-entzündliche Darmerkrankungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-59104-8_31
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