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Sport und Bewegung zur Prävention von gastrointestinalen Tumorerkrankungen

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Prävention gastroenterologischer Tumorerkrankungen
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Zusammenfassung

Eine große Anzahl epidemiologische Studien zeigt, dass regelmäßige körperliche Bewegung das Erkrankungsrisiko für verschiedene gastrointestinale Tumorerkrankungen senken kann. Das Ausmaß der relativen Risikoreduktion liegt dabei zwischen 0 bis 21 %. Absolut gesehen lassen sich beispielsweise geschätzte 11,3 % aller Darmkrebsfälle in Deutschland auf einen Mangel an hinreichender Bewegung zurückführen. Plausible biologische Mechanismen können diese Beobachtung erklären. Damit weist körperliche Bewegung als veränderbarer Lebensstilfaktor ein substanzielles Potenzial für die bevölkerungsbezogene Krebsprävention von gastrointestinalen Erkrankungen auf. Gegenwärtige Empfehlungen legen nahe, täglich mindestens 30 bis 60 min moderat körperlich aktiv zu sein.

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Literatur

  • Behrens G, Matthews CE, Moore SC, Freedman ND, McGlynn KA, Everhart JE, Hollenbeck AR, Leitzmann MF (2013) The association between frequency of vigorous physical activity and hepatobiliary cancers in the NIH-AARP Diet and Health Study. Eur J Epidemiol 28:55–66

    Article  PubMed  PubMed Central  Google Scholar 

  • Behrens G, Jochem C, Keimling M, Ricci C, Schmid D, Leitzmann MF (2014) The association between physical activity and gastroesophageal cancer: systematic review and meta-analysis. Eur J Epidemiol 29:151–170

    Article  PubMed  Google Scholar 

  • Behrens G, Jochem C, Schmid D, Keimling M, Ricci C, Leitzmann MF (2015) Physical activity and risk of pancreatic cancer: a systematic review and meta-analysis. Eur J Epidemiol 30:279–298

    Article  PubMed  Google Scholar 

  • Behrens G, Gredner T, Stock C, Leitzmann MF, Brenner H, Mons U (2018) Cancers due to excess weight, low physical activity, and unhealthy diet. Dtsch Arztebl Int 115:578–585

    PubMed  Google Scholar 

  • Boyle T, Heyworth J, Bull F, McKerracher S, Platell C, Fritschi L (2011) Timing and intensity of recreational physical activity and the risk of subsite-specific colorectal cancer. Cancer Causes Control 22:1647–1658

    Article  PubMed  Google Scholar 

  • Boyle T, Keegel T, Bull F, Heyworth J, Fritschi L (2012) Physical activity and risks of proximal and distal colon cancers: a systematic review and meta-analysis. J Natl Cancer Inst 104:1548–1561

    Article  PubMed  Google Scholar 

  • Buron Pust A, Alison R, Blanks R, Pirie K, Gaitskell K, Barnes I, Gathani T, Reeves G, Beral V, Green J, Million Women Study Collaborators (2017) Heterogeneity of colorectal cancer risk by tumour characteristics: Large prospective study of UK women. Int J Cancer 140:1082–1090

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dar NA, Shah IA, Bhat GA, Makhdoomi MA, Iqbal B, Rafiq R, Nisar I, Bhat AB, Nabi S, Masood A, Shah SA, Lone MM, Zargar SA, Islami F, Boffetta P (2013) Socioeconomic status and esophageal squamous cell carcinoma risk in Kashmir, India. Cancer Sci 104:1231–1236

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Eaglehouse YL, Koh WP, Wang R, Aizhen J, Yuan JM, Butler LM (2017) Physical activity, sedentary time, and risk of colorectal cancer: the Singapore Chinese Health Study. Eur J Cancer Prev 26:469–475

    Article  PubMed  PubMed Central  Google Scholar 

  • Frank LL, Sorensen BE, Yasui Y, Tworoger SS, Schwartz RS, Ulrich CM, Irwin ML, Rudolph RE, Rajan KB, Stanczyk F, Bowen D, Weigle DS, Potter JD, McTiernan A (2005) Effects of exercise on metabolic risk variables in overweight postmenopausal women: a randomized clinical trial. Obes Res 13:615–625

    Article  PubMed  Google Scholar 

  • Friedenreich CM (2011) Physical activity and breast cancer: review of the epidemiologic evidence and biologic mechanisms. Recent Results Cancer Res 188:125–139

    Article  CAS  PubMed  Google Scholar 

  • Friedenreich CM, O’Reilly R, Shaw E, Stanczyk FZ, Yasui Y, Brenner DR, Courneya KS (2016) Inflammatory marker changes in postmenopausal women after a year-long exercise intervention comparing high versus moderate volumes. Cancer Prev Res (Phila) 9:196–203

    Article  CAS  Google Scholar 

  • Harriss DJ, Cable NT, George K, Reilly T, Renehan AG, Haboubi N (2007) Physical activity before and after diagnosis of colorectal cancer: disease risk, clinical outcomes, response pathways and biomarkers. Sports Med 37:947–960

    Article  PubMed  Google Scholar 

  • Hawley JA, Lessard SJ (2008) Exercise training-induced improvements in insulin action. Acta Physiol (Oxf) 192:127–135

    Article  CAS  Google Scholar 

  • Hojman P (2017) Exercise protects from cancer through regulation of immune function and inflammation. Biochem Soc Trans 45:905–911

    Article  CAS  PubMed  Google Scholar 

  • Hojman P, Gehl J, Christensen JF, Pedersen BK (2018) Molecular mechanisms linking exercise to cancer prevention and treatment. Cell Metab 27:10–21

    Article  CAS  PubMed  Google Scholar 

  • Husemann B, Neubauer MG, Duhme C (1980) Sedentary occupation and recto-sigmoidal neoplasms. Onkologie 3:168–171

    CAS  PubMed  Google Scholar 

  • Irwin ML, Varma K, Alvarez-Reeves M, Cadmus L, Wiley A, Chung GG, DiPietro L, Mayne ST, Yu H (2009) Randomized controlled trial of aerobic exercise on insulin and insulin-like growth factors in breast cancer survivors: the Yale Exercise and Survivorship study. Cancer Epidemiol Biomarkers Prev 18:306–313

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ivy JL (1997) Role of exercise training in the prevention and treatment of insulin resistance and non-insulin-dependent diabetes mellitus. Sports medicine 24:321–336

    Article  CAS  PubMed  Google Scholar 

  • Keum N, Bao Y, Smith-Warner SA, Orav J, Wu K, Fuchs CS, Giovannucci EL (2016) Association of physical activity by type and intensity with digestive system cancer risk. JAMA oncology 2:1146–1153

    Article  PubMed  PubMed Central  Google Scholar 

  • Koelwyn GJ, Quail DF, Zhang X, White RM, Jones LW (2017) Exercise-dependent regulation of the tumour microenvironment. Nat Rev Cancer 17:620–632

    Article  PubMed  CAS  Google Scholar 

  • Kruk J (2009) Intensity of lifetime physical activity and breast cancer risk among Polish women. J Sports Sci 27:437–445

    Article  PubMed  Google Scholar 

  • Kyrgiou M, Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, Martin-Hirsch P, Tsilidis KK (2017) Adiposity and cancer at major anatomical sites: umbrella review of the literature. BMJ 356:j477

    Article  PubMed  PubMed Central  Google Scholar 

  • Kyu HH, Bachman VF, Alexander LT, Mumford JE, Afshin A, Estep K, Veerman JL, Delwiche K, Iannarone ML, Moyer ML, Cercy K, Vos T, Murray CJ, Forouzanfar MH (2016) Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta-analysis for the Global Burden of Disease Study 2013. BMJ 354:i3857

    Article  PubMed  PubMed Central  Google Scholar 

  • Liu L, Shi Y, Li T, Qin Q, Yin J, Pang S, Nie S, Wei S (2016) Leisure time physical activity and cancer risk: evaluation of the WHO’s recommendation based on 126 high-quality epidemiological studies. Br J Sports Med 50:372–378

    Article  PubMed  Google Scholar 

  • Lugo D, Pulido AL, Mihos CG, Issa O, Cusnir M, Horvath SA, Lin J, Santana O (2019) The effects of physical activity on cancer prevention, treatment and prognosis: A review of the literature. Complementary therapies in medicine 44:9–13

    Article  PubMed  Google Scholar 

  • Mahmood S, MacInnis RJ, English DR, Karahalios A, Lynch BM (2017) Domain-specific physical activity and sedentary behaviour in relation to colon and rectal cancer risk: a systematic review and meta-analysis. Int J Epidemiol 46:1797–1813

    Article  PubMed  Google Scholar 

  • McTiernan A (2008) Mechanisms linking physical activity with cancer. Nat Rev Cancer 8: 205–211

    Google Scholar 

  • McTiernan A, Wu L, Chen C, Chlebowski R, Mossavar-Rahmani Y, Modugno F, Perri MG, Stanczyk FZ, Van Horn L, Wang CY (2006) Relation of BMI and physical activity to sex hormones in postmenopausal women. Obesity(SilverSpring) 14:1662–1677

    CAS  Google Scholar 

  • McTiernan A, Friedenreich CM, Katzmarzyk PT, Powell KE, Macko R, Buchner D, Pescatello LS, Bloodgood B, Tennant B, Vaux-Bjerke A, George SM, Troiano RP, Piercy KL, Physical Activity Guidelines Advisory Committee (2019) Physical activity in cancer prevention and survival: a systematic review. Med Sci Sports Exerc 51:1252–1261

    Article  PubMed  PubMed Central  Google Scholar 

  • Moore SC, Lee IM, Weiderpass E, Campbell PT, Sampson JN, Kitahara CM, Keadle SK, Arem H, Berrington de Gonzalez A, Hartge P, Adami HO, Blair CK, Borch KB, Boyd E, Check DP, Fournier A, Freedman ND, Gunter M, Johannson M, Khaw KT, Linet MS, Orsini N, Park Y, Riboli E, Robien K, Schairer C, Sesso H, Spriggs M, Van Dusen R, Wolk A, Matthews CE, Patel AV (2016) Association of leisure-time physical activity with risk of 26 types of cancer in 1.44 million adults. JAMA intern med 176:816–825

    Article  PubMed  PubMed Central  Google Scholar 

  • Moreno-Villanueva M, Kramer A, Hammes T, Venegas-Carro M, Thumm P, Burkle A, Gruber M (2019) Influence of Acute Exercise on DNA Repair and PARP Activity before and after Irradiation in Lymphocytes from Trained and Untrained Individuals. Int J Mol Sci 20:2999

    Article  CAS  PubMed Central  Google Scholar 

  • Neilson HK, Friedenreich CM, Brockton NT, Millikan RC (2009) Physical activity and postmenopausal breast cancer: proposed biologic mechanisms and areas for future research. Cancer Epidemiol Biomarkers Prev 18:11–27

    Article  CAS  PubMed  Google Scholar 

  • Noor NM, Banim PJ, Luben RN, Khaw KT, Hart AR (2016) Investigating physical activity in the etiology of pancreatic cancer: the age at which this is measured is important and is independent of body mass index. Pancreas 45:388–393

    Article  PubMed  PubMed Central  Google Scholar 

  • O’Donovan G, Lee IM, Hamer M, Stamatakis E (2017) Association of „Weekend Warrior“ and other leisure time physical activity patterns with risks for all-cause, cardiovascular disease, and cancer mortality. JAMA intern med 177:335–342

    Article  PubMed  Google Scholar 

  • Pedersen BK, Hoffman-Goetz L (2000) Exercise and the immune system: regulation, integration, and adaptation. Physiol Rev 80:1055–1081

    Article  CAS  PubMed  Google Scholar 

  • Perez-Martin A, Raynaud E, Mercier J (2001) Insulin resistance and associated metabolic abnormalities in muscle: effects of exercise. Obes Rev 2:47–59

    Article  CAS  PubMed  Google Scholar 

  • Psaltopoulou T, Ntanasis-Stathopoulos I, Tzanninis IG, Kantzanou M, Georgiadou D, Sergentanis TN (2016) Physical activity and gastric cancer risk: a systematic review and meta-analysis. Clin J Sport Med 26:445–464

    Article  PubMed  Google Scholar 

  • Schmid D, Behrens G, Matthews CE, Leitzmann MF (2016) Physical activity and risk of colon cancer in diabetic and nondiabetic US adults. Mayo Clin Proc 91:1693–1705

    Article  PubMed  Google Scholar 

  • Schmitz KH, Courneya KS, Matthews C, Demark-Wahnefried W, Galvao DA, Pinto BM, Irwin ML, Wolin KY, Segal RJ, Lucia A, Schneider CM, von Gruenigen VE, Schwartz AL (2010) American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc 42:1409–1426

    Article  PubMed  Google Scholar 

  • Shaw E, Farris MS, Stone CR, Derksen JWG, Johnson R, Hilsden RJ, Friedenreich CM, Brenner DR (2018) Effects of physical activity on colorectal cancer risk among family history and body mass index subgroups: a systematic review and meta-analysis. BMC Cancer 18:71

    Article  PubMed  PubMed Central  Google Scholar 

  • Shiroma EJ, Lee IM, Schepps MA, Kamada M, Harris TB (2019) Physical activity patterns and mortality: the weekend warrior and activity bouts. Med Sci Sports Exerc 51:35–40

    Article  PubMed  PubMed Central  Google Scholar 

  • Sjoestroem M, Oja P, Hagstroemer M, Smith BJ, Bauman A (2006) Health-enhancing physical activity across European Union countries: the Eurobarometer study. J Public Health 14:291–300

    Article  Google Scholar 

  • Smith JK, Dykes R, Douglas JE, Krishnaswamy G, Berk S (1999) Long-term exercise and atherogenic activity of blood mononuclear cells in persons at risk of developing ischemic heart disease. JAMA 281:1722–1727

    Article  CAS  PubMed  Google Scholar 

  • Stewart LK, Flynn MG, Campbell WW, Craig BA, Robinson JP, McFarlin BK, Timmerman KL, Coen PM, Felker J, Talbert E (2005) Influence of exercise training and age on CD14 + cell-surface expression of toll-like receptor 2 and 4. Brain BehavImmun 19:389–397

    CAS  Google Scholar 

  • Wiskemann J, Friedmann-Bette B (2015) Potenzial körperlicher Aktivität in Prävention und Therapie chronischer Erkrankungen. Aktuelle Ernährungsmedizin 40:389–408

    Article  Google Scholar 

  • Wolin KY, Tuchman H (2011) Physical activity and gastrointestinal cancer prevention. Recent Results Cancer Res 186:73–100

    Article  PubMed  Google Scholar 

  • Woods JA, Davis JM, Smith JA, Nieman DC (1999) Exercise and cellular innate immune function. Med Sci Sports Exerc 31:57–66

    Article  CAS  PubMed  Google Scholar 

  • World Cancer Research Fund/American Institute of Cancer Research. Continuous Update Project Expert Report 2018. Physical activity and the risk of cancer 2018

    Google Scholar 

  • World Health Organization (2010) Global recommandations on physical activity for health. WHO

    Google Scholar 

  • Wu L, Zheng W, Xiang YB, Gao YT, Li HL, Cai H, Shu XO (2018) Physical activity and pancreatic cancer risk among Urban Chinese: results from two prospective cohort studies. Cancer Epidemiol Biomarkers Prev 27:479–487

    Article  PubMed  PubMed Central  Google Scholar 

  • You T, Berman DM, Ryan AS, Nicklas BJ (2004) Effects of hypocaloric diet and exercise training on inflammation and adipocyte lipolysis in obese postmenopausal women. J Clin Endocrinol Metab 89:1739–1746

    Article  CAS  PubMed  Google Scholar 

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Wiskemann, J. (2020). Sport und Bewegung zur Prävention von gastrointestinalen Tumorerkrankungen. In: Schilling, D., F. Riemann, J. (eds) Prävention gastroenterologischer Tumorerkrankungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-58879-6_4

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  • DOI: https://doi.org/10.1007/978-3-662-58879-6_4

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