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Braun-Falco´s Dermatology pp 1–17Cite as

Acquired Disorders of Collagen and Elastin

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Abstract

Skin atrophy is associated with a variety of acquired diseases and is characterized by a marked reduction of the extracellular matrix components, with subsequent atrophy of the dermis, and, secondarily, of the epidermis and subcutis. Dermal and/or subcutaneous atrophy can be both focal and diffuse. Dermal atrophy leads to a pronounced loss of collagen fibrils or loss of proteoglycans and elastic fibers, along with a reduction in glycoproteins. A sole atrophy of the epidermis is rare; it often occurs in combination with dermal atrophy. Malfunction and depletion of adult stem cells, limited proliferative potential of dermal cells in response to damage and stress (e.g., UV damage), as well as impairment of angiogenesis and neurogenic supply contribute to dermal atrophy. The most pronounced clinical form of skin atrophy is found in acrodermatitis chronica atrophicans, the late phase of an infection with borrelia burgdorferi.

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Author information

Authors and Affiliations

  1. Department of Dermatology and Allergic Diseases, Ulm University, Ulm, Germany

    Karin Scharffetter-Kochanek & Evgenia Makrantonaki

Authors
  1. Karin Scharffetter-Kochanek
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  2. Evgenia Makrantonaki
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Corresponding author

Correspondence to Karin Scharffetter-Kochanek .

Editor information

Editors and Affiliations

  1. Department of Dermatology, University of Munich, Munich, Germany

    Gerd Plewig

  2. Department of Dermatology, University of Munich, Munich, Germany

    Lars French

  3. Department of Dermatology, University of Munich, Munich, Germany

    Thomas Ruzicka

  4. Department of Dermatology, Venerology and Allergology, Frankfurt University Hospital, Frankfurt, Germany

    Roland Kaufmann

  5. Clinic for Dermatology and Allergology, University of Marburg, Marburg, Germany

    Michael Hertl

Section Editor information

  1. Clinic for Dermatology and Allergology, University of Marburg, Marburg, Germany

    Michael Hertl

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Scharffetter-Kochanek, K., Makrantonaki, E. (2020). Acquired Disorders of Collagen and Elastin. In: Plewig, G., French, L., Ruzicka, T., Kaufmann, R., Hertl, M. (eds) Braun-Falco´s Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-58713-3_52-1

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  • DOI: https://doi.org/10.1007/978-3-662-58713-3_52-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-58713-3

  • Online ISBN: 978-3-662-58713-3

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