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Surgery of the Meniscus pp 23–33Cite as

Histology-Ultrastructure-Biology

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Abstract

The menisci are nonuniform and heterogeneous structures with segmental variations according to its biology and function. It is a fibrocartilaginous tissue that plays a central role on the joint kinematics. However, they are also the most frequently injured structures of the human knee. In the advent of new technologies including tissue engineering and regenerative medicine, it is critical to deeper understand its ultrastructure and physiological function aiming to find ways for not only to enhance the repair and/or replacement approached but also to develop novel regenerative strategies. Herein, the presented work aims to describe the most relevant anatomic and biologic features of the meniscus.

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References

  1. Ahmed N, Vogel B, Rohde E, Strunk D, Grifka J, Schulz MB, Grassel S (2006) CD45-positive cells of haematopoietic origin enhance chondrogenic marker gene expression in rat marrow stromal cells. Int J Mol Med 18(2):233–240

    CAS  PubMed  Google Scholar 

  2. Anderson AF, Irrgang JJ, Dunn W, Beaufils P, Cohen M, Cole BJ, Coolican M, Ferretti M, Glenn RE Jr, Johnson R, Neyret P, Ochi M, Panarella L, Siebold R, Spindler KP, Ait Si Selmi T, Verdonk P, Verdonk R, Yasuda K, Kowalchuk DA (2011) Interobserver reliability of the International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine (ISAKOS) classification of meniscal tears. Am J Sports Med 39(5):926–932. doi:10.1177/0363546511400533

    Article  PubMed  Google Scholar 

  3. Arnoczky SP, Warren RF (1982) Microvasculature of the human meniscus. Am J Sports Med 10(2):90–95

    Article  CAS  PubMed  Google Scholar 

  4. Beaufils P, Englund M, Järvinen TLN, Pereira H, Pujol N (2014) How to share guidelines in daily practice on meniscus repair, degenerate meniscal lesion, and meniscectomy. In: Zaffagnini S, Becker R, Kerkhoffs GMMJ, Espregueira-Mendes J, van Dijk CN (eds) ESSKA instructional course lecture book Amsterdam 2014. Springer, Berlin, pp 97–112

    Chapter  Google Scholar 

  5. Beaupre A, Choukroun R, Guidouin R, Garneau R, Gerardin H, Cardou A (1986) Knee menisci. Correlation between microstructure and biomechanics. Clin Orthop Relat Res 208:72–75

    PubMed  Google Scholar 

  6. Bourne RB, Finlay JB, Papadopoulos P, Andreae P (1984) The effect of medial meniscectomy on strain distribution in the proximal part of the tibia. J Bone Joint Surg Am 66(9):1431–1437

    CAS  PubMed  Google Scholar 

  7. Brian D, Mackenzie WG, Shim SS, Leung G (1985) The vascular and nerve supply of the human meniscus. Arthroscopy 1(1):58–62

    Article  Google Scholar 

  8. Brody JM, Hulstyn MJ, Fleming BC, Tung GA (2007) The meniscal roots: gross anatomic correlation with 3-T MRI findings. AJR Am J Roentgenol 188(5):W446–W450. doi:10.2214/AJR.06.0509

    Article  PubMed  Google Scholar 

  9. Bullough PG, Munuera L, Murphy J, Weinstein AM (1970) The strength of the menisci of the knee as it relates to their fine structure. J Bone Joint Surg 52(3):564–567

    CAS  Google Scholar 

  10. Bursac P, Arnoczky S, York A (2009) Dynamic compressive behavior of human meniscus correlates with its extra-cellular matrix composition. Biorheology 46(3):227–237. doi:10.3233/BIR-2009-0537

    CAS  PubMed  Google Scholar 

  11. McDevitt CA, Webber RJ (1990) The ultrastructure and biochemistry of meniscal cartilage. Clin Orthop Relat Res 252:8–18

    PubMed  Google Scholar 

  12. Cengiz IF, Pereira H, Pego JM, Sousa N, Espregueira-Mendes J, Oliveira JM, Reis RL (2015a) Segmental and regional quantification of 3D cellular density of human meniscus from osteoarthritic knee. Journal of Tissue Engineering and Regenerative Medicine:Epub ahed of print. doi:10.1002/term.2082

    Google Scholar 

  13. Cengiz IF, Pitikakis M, Parascandolo P, Cesario L, Vosilla L, Viano G, Oliveira JM, Reis RL (2015b) Segmentation of meniscus tissue from medical images for the use of tissue engineering. Paper presented at the CARS, Computer Assisted Radiology and Surgery 29th International Congress and Exhibition, Barcelona

    Google Scholar 

  14. Cheung HS (1987) Distribution of type I, II, III and V in the pepsin solubilized collagens in bovine menisci. Connect Tissue Res 16(4):343–356

    Article  CAS  PubMed  Google Scholar 

  15. Cucchiarini M, Schmidt K, Frisch J, Kohn D, Madry H (2015) Overexpression of TGF-beta via rAAV-Mediated Gene Transfer Promotes the Healing of Human Meniscal Lesions Ex Vivo on Explanted Menisci. Am J Sports Med 43(5):1197–1205. doi:10.1177/0363546514567063

    Article  PubMed  Google Scholar 

  16. Fayard JM, Pereira H, Servien E, Lustig S, Neyret P (2010) Meniscectomy global results-complications. The Meniscus. Springer, Berlin/Heidelberg. doi:10.1007/978-3-642-02450-4

    Google Scholar 

  17. Fukubayashi T, Kurosawa H (1980) The contact area and pressure distribution pattern of the knee. A study of normal and osteoarthrotic knee joints. Acta Orthop Scand 51(6):871–879

    Article  CAS  PubMed  Google Scholar 

  18. Gelber PE, Isart A, Erquicia JI, Pelfort X, Tey-Pons M, Monllau JC (2015) Partial meniscus substitution with a polyurethane scaffold does not improve outcome after an open-wedge high tibial osteotomy. Knee Surg Sports Traumatol Arthrosc 23(1):334–339. doi:10.1007/s00167-014-3206-z

    Article  PubMed  Google Scholar 

  19. Ghadially FN, Thomas I, Yong N, Lalonde JM (1978) Ultrastructure of rabbit semilunar cartilages. J Anat 125(Pt 3):499–517

    CAS  PubMed  PubMed Central  Google Scholar 

  20. Ghosh P, Taylor TK (1987) The knee joint meniscus.A fibrocartilage of some distinction. Clin Orthop Relat Res 224:52–63

    PubMed  Google Scholar 

  21. Gunja NJ, Dujari D, Chen A, Luengo A, Fong JV, Hung CT (2012) Migration responses of outer and inner meniscus cells to applied direct current electric fields. J Orthop Res 30(1):103–111. doi:10.1002/jor.21489

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Gupte CM, Bull AM, Thomas RD, Amis AA (2003) The meniscofemoral ligaments: secondary restraints to the posterior drawer. Analysis of anteroposterior and rotary laxity in the intact and posterior-cruciate-deficient knee. J Bone Joint Surg 85(5):765–773

    Google Scholar 

  23. Gupte CM, Smith A, McDermott ID, Bull AM, Thomas RD, Amis AA (2002) Meniscofemoral ligaments revisited. Anatomical study, age correlation and clinical implications. J Bone Joint Surg 84(6):846–851

    Article  CAS  Google Scholar 

  24. Herwig J, Egner E, Buddecke E (1984) Chemical changes of human knee joint menisci in various stages of degeneration. Ann Rheum Dis 43(4):635–640

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Killian ML, Lepinski NM, Haut RC, Haut Donahue TL (2010) Regional and zonal histo-morphological characteristics of the lapine menisci. Anat Rec (Hoboken) 293(12):1991–2000. doi:10.1002/ar.21296

    Article  Google Scholar 

  26. Kohn D, Moreno B (1995) Meniscus insertion anatomy as a basis for meniscus replacement: a morphological cadaveric study. Arthroscopy 11(1):96–103

    Article  CAS  PubMed  Google Scholar 

  27. Kurosawa H, Fukubayashi T, Nakajima H (1980) Load-bearing mode of the knee joint: physical behavior of the knee joint with or without menisci. Clin Orthop Relat Res 149:283–290

    PubMed  Google Scholar 

  28. Lai JH, Levenston ME (2010) Meniscus and cartilage exhibit distinct intra-tissue strain distributions under unconfined compression. Osteoarthritis Cartilage 18(10):1291–1299, http://dx.doi.org/10.1016/j.joca.2010.05.020

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Levy IM, Torzilli PA, Warren RF (1982) The effect of medial meniscectomy on anterior-posterior motion of the knee. J Bone Joint Surg Am 64(6):883–888

    CAS  PubMed  Google Scholar 

  30. Makris EA, Hadidi P, Athanasiou KA (2011) The knee meniscus: structure-function, pathophysiology, current repair techniques, and prospects for regeneration. Biomaterials 32(30):7411–7431. doi:10.1016/j.biomaterials.2011.06.037

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. McDermott ID, Masouros SD, Amis AA (2008) Biomechanics of the menisci of the knee. Curr Orthop 22:193–201

    Article  Google Scholar 

  32. McDevitt CA, Webber RJ (1992) The ultrastructure and biochemistry of meniscal cartilage. Clin Orthop Relat Res 252:8–18

    Google Scholar 

  33. Melrose J, Smith S, Cake M, Read R, Whitelock J (2005) Comparative spatial and temporal localisation of perlecan, aggrecan and type I, II and IV collagen in the ovine meniscus: an ageing study. Histochem Cell Biol 124(3-4):225–235. doi:10.1007/s00418-005-0005-0

    Article  CAS  PubMed  Google Scholar 

  34. Miller RR, McDevitt CA (1991) Thrombospondin in ligament, meniscus and intervertebral disc. Biochim Biophys Acta 1115(1):85–88

    Article  CAS  PubMed  Google Scholar 

  35. Monllau JC, Gelber PE, Abat F, Pelfort X, Abad R, Hinarejos P, Tey M (2011) Outcome after partial medial meniscus substitution with the collagen meniscal implant at a minimum of 10 years' follow-up. Arthroscopy 27(7):933–943. doi:10.1016/j.arthro.2011.02.018

    Article  PubMed  Google Scholar 

  36. Nakata K, Shino K, Hamada M, Mae T, Miyama T, Shinjo H, Horibe S, Tada K, Ochi T, Yoshikawa H (2001) Human meniscus cell: characterization of the primary culture and use for tissue engineering. Clin Orthop Relat Res 391(Suppl):S208–S218

    Article  PubMed  Google Scholar 

  37. Osawa A, Harner CD, Gharaibeh B, Matsumoto T, Mifune Y, Kopf S, Ingham SJ, Schreiber V, Usas A, Huard J (2013) The use of blood vessel-derived stem cells for meniscal regeneration and repair. Med Sci Sports Exerc 45(5):813–823. doi:10.1249/MSS.0b013e31827d1e06

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Pereira H, Caridade SG, Frias AM, Silva-Correia J, Pereira DR, Cengiz IF, Mano JF, Oliveira JM, Espregueira-Mendes J, Reis RL (2014) Biomechanical and cellular segmental characterization of human meniscus: building the basis for Tissue Engineering therapies. Osteoarthritis Cartilage 22(9):1271–1281. doi:10.1016/j.joca.2014.07.001

    Article  CAS  PubMed  Google Scholar 

  39. Pereira H, Frias AM, Oliveira JM, Espregueira-Mendes J, Reis RL (2011) Tissue engineering and regenerative medicine strategies in meniscus lesions. Arthroscopy 27(12):1706–1719. doi:10.1016/j.arthro.2011.08.283

    Article  PubMed  Google Scholar 

  40. Pereira H, Silva-Correia J, Oliveira JM, Reis RL, Espregueira-Mendes J (2013) Future Trends in the Treatment of Meniscus Lesions: From Repair to Regeneration. In: Verdonk R, Espregueira-Mendes J, Monllau JC (eds) Meniscal transplantation. Springer, Heidelberg/New York/Dordrecht/London, pp 103–114

    Chapter  Google Scholar 

  41. Pereira H, Silva-Correia J, Oliveira JM, Reis RL, Espregueira-Mendes J (2013) The Meniscus: Basic Science. In: Verdonk R, Espregueira-Mendes J, Monllau JC (eds) Meniscal transplantation. Springer, Heidelberg/New York/Dordrecht/London, pp 7–14

    Chapter  Google Scholar 

  42. Scott PG, Nakano T, Dodd CM (1997) Isolation and characterization of small proteoglycans from different zones of the porcine knee meniscus. Biochim Biophys Acta 1336(2):254–262

    Article  CAS  PubMed  Google Scholar 

  43. Smillie IS (1972) Injuries of the knee joint, 4th edn. Churcill Livingstone, Edinburgh

    Google Scholar 

  44. Smith CD, Masouros S, Hill AM, Wallace AL, Amis AA, Bull AMJ (2008) Mechanical testing of intra-articular tissues. Relating experiments to physiological function. Curr Orthop 22:341–348

    Article  Google Scholar 

  45. Sweigart MA, Athanasiou KA (2001) Toward tissue engineering of the knee meniscus. Tissue Eng 7(2):111–129. doi:10.1089/107632701300062697

    Article  CAS  PubMed  Google Scholar 

  46. Van der Bracht H, Verdonk R, Verbruggen G, et al. (2007) Cell based meniscus tissue engineering. In: Ashammakhi N, Reis R, Chiellini E (eds) Topics in tissue engineering, Vol. 3. Biomaterials and Tissue Engineering Group (BTE), http://www.oulu.fi/spareparts/ebook_topics_in_t_e_vol3/.

  47. Verdonk P, Beaufils P, Bellemans J, Djian P, Heinrichs EL, Huysse W, Laprell H, Siebold R, Verdonk R (2012) Successful treatment of painful irreparable partial meniscal defects with a polyurethane scaffold: two-year safety and clinical outcomes. Am J Sports Med 40(4):844–853. doi:10.1177/0363546511433032

    Article  PubMed  Google Scholar 

  48. Verdonk PC, Forsyth RG, Wang J, Almqvist KF, Verdonk R, Veys EM, Verbruggen G (2005) Characterisation of human knee meniscus cell phenotype. Osteoarthritis Cartilage 13(7):548–560. doi:10.1016/j.joca.2005.01.010, S1063-4584(05)00050-6 [pii]

    Article  CAS  PubMed  Google Scholar 

  49. Verdonk R (2011) The meniscus: past, present and future. Knee Surg Sports Traumatol Arthrosc 19(2):145–146. doi:10.1007/s00167-010-1333-8

    Article  PubMed  Google Scholar 

  50. Vincent JP, Magnussen RA, Gezmez F, Uguen A, Jacobi M, Weppe F, Al-Saati MF, Lustig S, Demey G, Servien E, Neyret P (2012) The anterolateral ligament of the human knee: an anatomic and histologic study. Knee Surg Sports Traumatol Arthrosc 20(1):147–152. doi:10.1007/s00167-011-1580-3

    Article  PubMed  Google Scholar 

  51. Walker PS, Hajek JV (1972) The load-bearing area in the knee joint. J Biomech 5(6):581–589

    Article  CAS  PubMed  Google Scholar 

  52. Wilmes P, Anagnostakos K, Weth C, Kohn D, Seil R (2008) The reproducibility of radiographic measurement of medial meniscus horn position. Arthroscopy 24(6):660–668. doi:10.1016/j.arthro.2007.12.012

    Article  PubMed  Google Scholar 

  53. Wilmes P, Pape D, Kohn D, Seil R (2007) The reproducibility of radiographic measurement of lateral meniscus horn position. Arthroscopy 23(10):1079–1086. doi:10.1016/j.arthro.2007.04.006

    Article  PubMed  Google Scholar 

  54. Zaffagnini S, Marcheggiani Muccioli GM, Lopomo N, Bruni D, Giordano G, Ravazzolo G, Molinari M, Marcacci M (2011) Prospective long-term outcomes of the medial Collagen Meniscus implant versus partial medial meniscectomy: a minimum 10-year follow-up study. Am J Sports Med 39(5):977–985. doi:10.1177/0363546510391179, 0363546510391179 [pii]

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Orthopedic Department, Centro Hospitalar Póvoa de Varzim - Vila do Conde, Vila do Conde, Portugal

    Hélder Pereira MD, Ibrahim Fatih Cengiz, Joana Silva-Correia, Joao Espregueira-Mendes, Joaquim Miguel Oliveira & Rui Luís Reis

  2. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, Univ. Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark – Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017, Guimarães, Portugal

    Hélder Pereira MD, Ibrahim Fatih Cengiz, Joana Silva-Correia, Joao Espregueira-Mendes, Joaquim Miguel Oliveira & Rui Luís Reis

  3. ICVS/3B’s – PT Government Associated Laboratory, Braga, Portugal

    Hélder Pereira MD

  4. Ripoll y De Prado Sports Clinic FIFA Medical Centre of Excellence, Murcia-Madrid, Spain

    Hélder Pereira MD

  5. Center of Experimental Orthopaedics, Saarland University Medical Center, Homburg, Germany

    Maggali Cucciarini

  6. Department of Orthopaedic Surgery, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

    Pablo E. Gelber

  7. ICATME– Hospital Universitari Quirón Dexeus, Barcelona, Spain

    Pablo E. Gelber

  8. Clínica do Dragão , Espregueira-Mendes Sports Centre & FIFA Medical Centre of Excellence, Porto, Portugal

    Joao Espregueira-Mendes

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  1. Hélder Pereira MD
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  2. Ibrahim Fatih Cengiz
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  3. Joana Silva-Correia
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  4. Maggali Cucciarini
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  5. Pablo E. Gelber
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  6. Joao Espregueira-Mendes
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  7. Joaquim Miguel Oliveira
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  8. Rui Luís Reis
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Corresponding author

Correspondence to Hélder Pereira MD .

Editor information

Editors and Affiliations

  1. Orthopaedics & Traumatology, Unit INSERM, Normandy University, Caen university Hos, Caen, France

    Christophe Hulet

  2. Orthopedic Department, Centro Hospitalar Póvoa de Varzim –Vila, Póvoa de Varzim, Porto, Portugal

    Helder Pereira

  3. University of Milan, Dpt. of Biomedical Sciences for Health, Milano, Italy

    Giuseppe Peretti

  4. Istituto Clinico Humanitas, Monza, Italy

    Matteo Denti

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Pereira, H. et al. (2016). Histology-Ultrastructure-Biology. In: Hulet, C., Pereira, H., Peretti, G., Denti, M. (eds) Surgery of the Meniscus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49188-1_3

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  • DOI: https://doi.org/10.1007/978-3-662-49188-1_3

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  • Online ISBN: 978-3-662-49188-1

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