Abstract
In recent years, it has been clinically and neuropathologically revealed that some neurodegenerative diseases such as Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and pure autonomic failure (PAF) are overlapping diseases: Lewy body diseases (LBD) has thus become a general term for these diseases. In fact, Lewy bodies are pathologically observed in the nervous system of these neurodegenerative diseases. Since LBD may present sympathetic impairment, several studies have evaluated the role of myocardial sympathetic imaging in these diseases. LBD usually present an abnormal myocardial sympathetic imaging using iodine-123-metaiodobenzylguanidine ([123I]-MIBG) scintigraphy, and this technique may be very useful in differential diagnosis between PD and other parkinsonisms such as in differential diagnosis between DLB and other dementias. PET tracers are also available to study myocardial sympathetic denervation and may help to quantify cardiac autonomic dysfunction in LBD.
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Abbreviations
- AADC:
-
Aromatic amino acid decarboxylase
- CBD:
-
Corticobasal degeneration
- DAT:
-
Dopamine transporter
- DLB:
-
Dementia with Lewy bodies
- FNE:
-
Fluoronorepinephrine
- FP-CIT:
-
[123I]-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropan
- IBZM:
-
[123I]-(S)-2-hydroxy-3-iodo-6-methoxy-N-[1-ethyl-2-pyrrodinyl)-methyl]benzamide
- LBD:
-
Lewy body diseases
- MSA:
-
Multiple system atrophy
- PAF:
-
Pure autonomic failure
- PD:
-
Parkinson’s disease
- PET:
-
Positron emission tomography
- PSP:
-
Progressive supranuclear palsy
- SPECT:
-
Single-photon emission computed tomography
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Treglia, G., Stefanelli, A., Carrio, I. (2015). Imaging the Functional Brain-Heart Axis: Neurodegenerative Diseases. In: Slart, R., Tio, R., Elsinga, P., Schwaiger, M. (eds) Autonomic Innervation of the Heart. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45074-1_21
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