Abstract
The cellular origins of human immunoglobulins have been investigated many times with immunofluorescence techniques since the original studies of Ortega and Mellors (1957). It has been found, for the most part, that plasma cells present in the red pulp of the spleen, in the medulla of lymph nodes, and in the bone marrow, contain only one type of immunoglobulin (Mellors and Korngold, 1963; Solomon, Fahey, and Malmgren, 1963; Burtin and Buffe, 1963; Bernier and Cebra 1964). Similar findings were made by Mellors and Korngold (1963) in an investigation of immunoglobulin synthesis by the cells of germinal centers of human lymphoid tissues. However, in another immunofluorescent study of immunoglobulins in lymphoid tissue, Chiappino and Pernis (1964) found consistently two types of immunoglobulins in a single germinal center.
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References
Avrameas, S., and T. Ternynck: Utilisation des polymères insolubles de proteines pour I’iso-lement d’antigènes et d’anticorps. C. R. Acad. Sci. (Paris) 262, 1175–1177 (1966).
Bernier, G. M., and J. J. Cebra: Polypeptide chains of human γ-globulin: cellular localization by fluorescent antibody. Science 144, 1590–1591 (1964).
Burtin, P., and D. Buffe: Immunofluorescent studies of human plasma cells in gamma and ßlK myelomas. Proc. Soc. exp. Biol. (N.Y.) 114, 171–175 (1963).
Chiappino, G., and B. Pernis: Demonstration with immunofluorescence of 19 S macroglobulins and 7 S gammaglobulins in different cells of the human spleen. Path. Microbiol. 27, 8–15 (1964).
Mellors, R. C., and L. Korngold: The cellular origin of human immunoglobulins (γ2, γ1M, γ1A). J. exp. Med. 118, 387–396 (1963).
Ortega, L. G., and R. C. Mellors: Cellular sites of formation of gammaglobulins. J. exp. Med. 106, 627–640 (1957).
Pernis, B., and G. Chiappino: Identification in human lymphoid tissues of cells that produce group 1 or group 2 gammaglobulins. Immunology 7, 500–506 (1964).
Solomon, A., J. L. Fahey and R. A. Malmgren: Immunohistologic localization of gamma-1-macroglobulins, beta-2 A myeloma proteins, 6, 6 S gamma myeloma proteins and Bence-Jones proteins. Blood 21, 403–423 (1963)
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Burtin, P., Buffe, D. (1967). Synthesis of Human Immunoglobulins in Germinal Centers. In: Cottier, H., Odartchenko, N., Schindler, R., Congdon, C.C. (eds) Germinal Centers in Immune Responses. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86837-5_14
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DOI: https://doi.org/10.1007/978-3-642-86837-5_14
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