Abstract
The transient production of monoclonal components of immunoglobulins (M-components) occurs normally in response to trauma, particular drug treatments, and infection with specific antigens (Haas et cd. 1990; Merlini and Aguzzi 1988). Chronic production can occur with malignancy (B cell, colon, prostate, and breast) and with rheumatoid arthritis, tuberculosis, cirrhosis, and several other chronic inflammatory and infectious processes (Merlini and Aguzzi 1988; Saleun et cd. 1982). However, in approximately 60–90% of persons identified with elevated M-components in community-based surveys, the elevation is chronic and unexplained (Saleun et cd. 1982; Axelsson et cd. 1966; Kyle et cd. 1972). These persons are given a diagnosis of monoclonal gammopathy of unknown significance (MGUS). Although MGUS is itself benign, it can evolve to amyloidosis, myeloma, or macroglobulinemia (Kyle 1993). To better understand the significance and consequences of MGUS, the author conducted a literature review. Two methodological issues that affect the interpretation of the literature are discussed first.
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Herrinton, L.J. (1996). The Epidemiology of Monoclonal Gammopathy of Unknown Significance: A Review. In: Potter, M., Rose, N.R. (eds) Immunology of Silicones. Current Topics in Microbiology and Immunology, vol 210. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85226-8_42
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