Abstract
In an attempt to combine morphologic, immunologic, and cytogenetic information, the Second MIC (morphology, immunology, cytogenetic) Cooperative Study Group (1988) has developed a new preliminary working classification for acute myeloid leukemia (AML) (1988). Despite their efforts however, the particular immunophenotypic characteristics of these proposed morphologic/cytogenetic subtypes are still poorly defined. In order to establish the immunologic marker profile of the MIC subgroup M2/t(8;21), we have immunologically phenotyped blast cells of 21 patients with this type of hematologic neoplasm. The heterogeneous clinical, hematologic, and cytogenetic features of our cases allowed us also to determine to what extent this phenotype depends on age and/or sex, whether it is modified in relapse or differs in de novo and secondary forms, and how it might be influenced by the presence of additional chromosome abnormalities.
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© 1993 Springer-Verlag Berlin · Heidelberg
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Haas, O.A., Köller, U., Grois, N., Nowotny, H. (1993). Immunophenotype of Hematologic Neoplasms with a Translocation t(8;21). In: Ludwig, WD., Thiel, E. (eds) Recent Advances in Cell Biology of Acute Leukemia. Recent Results in Cancer Research, vol 131. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84895-7_32
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DOI: https://doi.org/10.1007/978-3-642-84895-7_32
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