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Cellular Drug Sensitivity of Immunophenotypic Subgroups of Childhood Acute Lymphoblastic Leukemia

  • Conference paper
Recent Advances in Cell Biology of Acute Leukemia

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 131))

Abstract

The immunophenotype is one of the prognostic factors in children with acute lymphoblastic leukemia (ALL) (Crist et al. 1984, 1985, 1989; Sallan et al. 1980; Greaves et al. 1981; Pui et al. 1986). B-cell ALL (B-ALL) cases have the worst prognosis and patients with B-cell precursor ALL the most favorable prognosis. Precursor B-ALL can be subdivided into three groups: pro-B-ALL (CD10−, cytoplasmic μ chain− [cμ−]; common ALL (c-ALL) (CD10+/cμ−) and pre-B-ALL (CD10+ or −/cμ+). The small group of patients whose cells lack the common ALL (c-ALL) antigen characteristic of the earliest stage of B-cell differentiation (pro-B-ALL) show poorer responses by comparison with the c-ALL+ cases. In some studies the pre-B-ALL cases did worse than the cALL cases, but this is probably due to a small subset of patients with a specific chromosomal abnormality on their leukemic cells (Crist et al. 1990). Also, patients with T-cell ALL (T-ALL) have an unfavorable prognosis. Some of these findings are still controversial because in some studies the immunophenotype is related to other clinical and biological features like white blood cell (WBC) count and organomegaly. Also, when effective treatments are used, the prognostic value of immunophenotype could be diminished (Borowitz 1990; Poplack and Reaman 1988; Miller 1988).

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Authors and Affiliations

  1. Department of Pediatrics, Free University Hospital, 1081 HV, Amsterdam, The Netherlands

    R. Pieters, G. J. L. Kaspers, D. R. Huismans, A. H. Loonen & A. J. P. Veerman

  2. Dutch Childhood Leukemia Study Group, The Hague, The Netherlands

    E. R. van Wering, K. Hählen & A. J. P. Veerman

  3. Sophia’s Children’s Hospital, Subdivision Haemato-Oncology, Erasmus University, Rotterdam, The Netherlands

    K. Hählen

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  1. R. Pieters
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  2. G. J. L. Kaspers
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  3. E. R. van Wering
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  4. D. R. Huismans
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  5. A. H. Loonen
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  6. K. Hählen
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  7. A. J. P. Veerman
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Editors and Affiliations

  1. Abt. Hämatologie/Onkologie, Universitätsklinikum Steglitz, Hindenburgdamm 30, W-1000, Berlin 45, Germany

    Wolf-Dieter Ludwig  & Eckhard Thiel  & 

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© 1993 Springer-Verlag Berlin · Heidelberg

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Pieters, R. et al. (1993). Cellular Drug Sensitivity of Immunophenotypic Subgroups of Childhood Acute Lymphoblastic Leukemia. In: Ludwig, WD., Thiel, E. (eds) Recent Advances in Cell Biology of Acute Leukemia. Recent Results in Cancer Research, vol 131. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84895-7_22

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  • DOI: https://doi.org/10.1007/978-3-642-84895-7_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84897-1

  • Online ISBN: 978-3-642-84895-7

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