Summary
Adjuvant treatment with polyadenylic-polyuridylic acid poly A-poly U was tested in 300 patients with operable breast cancer who had all received the same locoregional treatment. They were randomized into two groups; 155 patients receiving 30 mg poly A-poly U i.v. once a week for 6 weeks and 145 controls. Overall survival was significantly improved in the poly A-Poly U group (P<0.05). The most striking difference (P < 0.03) was observed in the group of positive node patients, who had a 5-year relapse-free actuarial survival rate of 71% versus 47% in the controls.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bloom HJG, Richardson WW (1957) Histological grading and prognosis in breast cancer. Br J Cancer 11:359–362
Bonadonna G (1980) Improved disease-free and overall survival in operable breast cancer (N+) by surgical adjuvant immunotherapy. International Congress on Semology (abstr), p 56
Bonadonna G, Brusamolino E, Valagussa P, et al (1976) Combination chemotherapy as an adjuvant treatment in operable breast cancer. N Engl J Med 294:405–410
Braun W, Nakano M (1967) Antibody formation: Stimulation by polyadenylic and polycytidylic acids. Science 157:819–821
Braun W, Ishizuka M, Yajima Y, Webb D, Winchurch R (1971) Spectrum and mode of action of poly A. poly U. in the stimulation of immune responses. In: Beers RF, Braun W (eds) Biological effects of polynucleotides. Springer, Berlin Heidelberg New York, pp 139–156
Braun W, Plescia OJ, Raskowa J, Webb D (1971) Basic proteins and synthetic polynucleotides as modifiers of immunogenicity of syngeneic tumor cells. Isr J Med Sci 7:72–82
Cone ER, Johnson AG (1971) Regulation of the immune system by synthetic polynucleotides. III. Action an antigen reactive cells of thymic origin. J Exp Med 133:665–676
Donner M, Vaillier D, Lacour F (1977) Changes in lymphocytes subpopulations in mice receiving a single injection of poly A. poly U. Ann Immunol (Paris) 128:1039–1052
Fenster ED, Lacour F, Harel J (1975) Nuclear penetration and stimulation of nucleic acids synthesis by poly A. poly U. in mammalian cells. Exp Cell Res 94: 315–320
Lacour F, Spira A, Lacour J, Prade M (1972) Polyadenylic-polyuridylic acid an adjunct to surgery in the treatment of spontaneous mammary tumors in C3H/He mice and transplantable melanoma in hamster. Cancer Res 32:648–649
Lacour F, Delage G, Fenster E, Harel J (1975) Inhibitory action of poly A. poly U. on tumor growth. Enhancement of host immune response? In: Gotlieb AA, Plescia O, Bishop HL (eds) Fundamental aspects of neoplasia. Springer, Berlin Heidelberg New York, pp 123–138
Lacour J, Lacour F, Spira A, Delage G, Michelson AM (1974) Essai d’immunothérapie (poly A. poly U.) adjuvante dans le traitement du cancer du Scin. Bull Cancer (Paris) 61:275–280
Mantel N (1965) Evaluation of survival data and two new rank order statistics arising its consideration. Cancer Chemother Rep 50:163–171
Wanebo HY, Kemeny M, Pinsky CM, Hirshaut Y, Oettgen HF (1976) Influence of poly A. poly U. on immune response in cancer patients. Ann NY Acad Sci 277:288–298
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Lacour, F. et al. (1982). A New Adjuvant Treatment with PolyadenyliC-Polyuridylic Acid in Operable Breast Cancer. In: Mathé, G., Bonadonna, G., Salmon, S. (eds) Adjuvant Therapies of Cancer. Recent Results in Cancer Research, vol 80. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81685-7_32
Download citation
DOI: https://doi.org/10.1007/978-3-642-81685-7_32
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-81687-1
Online ISBN: 978-3-642-81685-7
eBook Packages: Springer Book Archive