Summary
The authors report here the case of a female patient who developed symmetrical polyneuropathy of the lower limbs a few months after she was found to have a myeloma with cryoglobulinemia. In musculocutaneous nerve biopsy material from this patient, electron microscopy showed pathologic changes in the nervous tissue together with axonal degeneration and demyelination. But the most striking finding was the presence in the endoneurial space, of numerous masses made up of closely packed tubular structures. These masses occurred also in the walls and even in the lumen of all the vasa nervorum. Their morphologic features and dimensions were identical to cryoprecipitate which the authors extracted from the serum and which they examined with electron microscope.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Olsson Y (1971) Studies on vascular permeability in peripheral nerves. Acta Neuropathol 17:114–126
Olsson Y, Reese TS (1971) Permeability of vasa nervorum and perineurium in mouse sciatic nerve studied by fluorescence and electron microscopy. J Neuropathol Exp Neurol 30: 105–119
Vital C, Vallat JM (in press 1980) Ultrastructural lesions of the human peripheral nerve. Masson (ed). Paris New York
Vallat JM, Desproges-Gotteron R, Leboutet MJ, Loubet A, Gualde N, Treves R (in press 1980) Cryoglobulinemic neuropathy: a pathological study. Ann Neurol
Walsh JC (1971) The neuropathy of multiple myeloma. An electrophysiological and histo-locial study. Arch Neurol 25:404–414
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Springer-Verlag
About this paper
Cite this paper
Vallat, J.M., Leboutet, M.J., Loubet, A. (1981). Cryoglobulinemic Neuropathy: Ultrastructural Study of the Nerve Capillaries. In: Jellinger, K., Gullotta, F., Mossakowski, M. (eds) Experimental and Clinical Neuropathology. Acta Neuropathologica Supplementum, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81553-9_74
Download citation
DOI: https://doi.org/10.1007/978-3-642-81553-9_74
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-10449-0
Online ISBN: 978-3-642-81553-9
eBook Packages: Springer Book Archive