Abstract
The current programs used to treat acute leukemia at Memorial-Sloan Kettering Cancer Center are determined on the basis of morphologic criteria and age. The following report describes the regimens used and the current experience at this Center. Although age may be an important factor in the ultimate response of the patient, the morphologic characteristics of the disease govern the therapeutic approach. In acute lymphoblastic leukemia (ALL), the L-2 protocol is used. In the acute non-lymphoblastic leukemias, myeloblastic, myelomonoblastic and monoblastic (AML), the L-6 protocol is followed. The age division is based on practical lines in that there are both adult and pediatric leukemic groups. However, there are only minor differences in the protocols due mainly to practical rather than real considerations.
This investigation was supported in part by USPHS Research Grants CA-05826 and CA-08748 from the National Cancer Institute, American Cancer Society Grant ET-2C, The John C. McCarroll Fund, Hearst Foundation Fund, and the United Leukemia Fund.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Aur,, R., Hustu,, O., Verzosa,, M., Simone,, J.: A comparative study of “prophylactic” craniospinal irradiation in 94 children with acute lymphocytic leukemia. Proc. Amer. Ass. Cancer Res. 12, 19 (1971).
Aur, R. J. A., Simone, J., Hustu, H. O., Walters, T., Burella, L., Pratt, C., Pindel, D.: Central nervous system therapy and combination chemotherapy of childhood lymphocytic leukemia. Blood (in press).
Bernard, J., Jacquillart, C., Weil, M., Boiron, M., Tanzer, J.: Present results on donaurubicin (rubidomycin, Donaumycin). Recent Results in Cancer Research. Advances in the treatment of acute (Blastic) leukemias, p. 3. Ed.: G. Mathe. New York: Springer 1970.
Burchenal, J. H.: Clinical evaluation and future prospects of asparaginase. Recent Results in Cancer Research. Advances in the treatment of acute (Blastic) leukemias, p. 20. Ed.: G. Mathe. New York: Springer 1970.
Clarkson, B. D., Fried, J., Strife, A., Sarai, Y., Ota, K., Ohkita, T., Masuda, R.: Studies of cellular proliferation in human leukemia. IV. Behavior of normal hematopoietic cells in three adults with acute leukemia given continuous infusions of -thymidine. Cancer (Philad.) 26, 1 (1970).
Clarkson, B. D., Fried, J.: Changing concepts of treatment in acute leukemia. Medical Clinics of North America, vol. 55, p. 561. Philadelphia-London-Toronto: W. B. Saunders Company 1971.
Clarkson, B., Krakoff, I., Burchenal, J., Karnofsky, D., Golbey, R., Oettgen, H., Dowling, M., Lipton, A.: Clinical results of treatment with E. Coli L-asparaginase in adults with leukemia, lymphoma, and solid tumors. Cancer (Philad.) 25, 279 (1970).
Clarkson, B. D., Ohkita, T., Ota, K., Fried, J.: Studies of cellular proliferation in human leukemia. I. Estimation of growth rates of leukemic and normal hematopoietic cells in two adults with acute leukemia given single injections of tritiated thymidine. J. clin. Invest. 46, 506 (1967).
Freireich, E. J., Bodey, G. P., Hart, J. S., Rodriguez, V., Whitecar, J. P., Frei, E. III.: Remission induction in adults with acute myelogenous leukemia. Recent Results in Cancer Research. Advances in the treatment of acute (Blastic) leukemias, p. 85. Ed.: G. MATHE. New York: Springer 1970.
Gee, T. S., Yu K.-P., Clarkson, B. D.: Treatment of adult acute leukemia with arabinosyl cytosine and thioguanine. Cancer (Philad.) 23, 1019 (1969).
Haghbin, M., Tan, C., Gee, T., Dowling, M., Clarkson, B., Sidhu, J., Murphy, M. L., Burchenal, J., Sykes, M.: Sequential intensive drug therapy in acute lymphoblastic leukemia (ALL) and leukosarcoma (LSA). Proc. Amer. Ass. Cancer Res. 12, 122 (1971).
Henderson, E. S.: Treatment of acute leukemia. Sem. Hemat. 6, 271 (1969).
Henderson, E. S., Samaha, R. J.: Evidence that drugs in multiple combinations have materially advanced the treatment of human malignancies. Cancer Res. 29, 2272 (1969).
Holland, J. F.: Who should treat acute leukemia ? J. Amer. med. Ass. 209, 1511 (1969).
Holland, J. F., Glidewell, O.: Complementary chemotherapy in acute leukemia. Recent Results in Cancer Research. Advances in the treatment of acute (Blastic) leukemias, p. 95. Ed.: G. MATHE. New York: Springer 1970.
Leukemia and Hematosarcoma Cooperative Group of the European Organisation for Research on the Treatment of Cancer (E. O. R. T. C.): Rubidomycin (or daunomycin): A clinical evaluation. Recent Results in Cancer Research. Advances in the treatment of acute (Blastic) leukemias, p. 9. Ed.: G. Mathe. New York: Springer 1970.
Mathe, G., Amiel, J. L., Schwarzenberg, L., Schneider, M., Cattan, A., Hay at, M., De Vassal, F., Schlumberger, J. R.: Methods and strategy for the treatment of acute lymphoblastic leukemia. Recent Results in Cancer Research. Advances in the treatment of acute (Blastic) leukemias, p. 109. Ed.: G. Mathe. New York: Springer 1970.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1973 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Dowling, M.D. et al. (1973). Comparative Results Obtained in the Treatment of Acute Leukemia. In: Mathé, G., Pouillart, P., Schwarzenberg, L. (eds) Nomenclature, Methodology and Results of Clinical Trials in Acute Leukemias. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 43. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80776-3_23
Download citation
DOI: https://doi.org/10.1007/978-3-642-80776-3_23
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-80778-7
Online ISBN: 978-3-642-80776-3
eBook Packages: Springer Book Archive