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In Vitro Interaction of Mycobacterium tuberculosis and Macrophages: Activation of Anti-mycobacterial Activity of Macrophages and Mechanisms of Anti-mycobacterial Activity

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Tuberculosis

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 215))

Abstract

Mycobacterium tuberculosis is an example of a facultative intracellular pathogen which will survive and multiply within macrophages from non-immune individuals. It is a central tenet of cell-mediated immunity to intracellular pathogens that macrophages are the principal effector cells and that, after exposure to products of specifically sensitized T cells, they acquire the ability to kill these pathogens (Mackaness 1968). Much of the basic data on which the idea of cell-mediated immunity is founded came from studies on immunity to mycobacterial infections (Lurie 1942; Suter 1953; Mackaness 1964, 1968).

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  1. Department of Microbiology and Immunology, University of Leicester, Leicester, LE1 9HN, UK

    L. O’Brien, B. Roberts & P. W. Andrew

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  1. Department of Health and Human Services, Immunology and Molecular Pathogenesis Section, Division of AIDS, STD and TB Laboratory Research, Centers for Disease Control and Prevention, 30333, Atlanta, GA, USA

    Thomas M. Shinnick Ph.D. (Chief) (Chief)

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O’Brien, L., Roberts, B., Andrew, P.W. (1996). In Vitro Interaction of Mycobacterium tuberculosis and Macrophages: Activation of Anti-mycobacterial Activity of Macrophages and Mechanisms of Anti-mycobacterial Activity. In: Shinnick, T.M. (eds) Tuberculosis. Current Topics in Microbiology and Immunology, vol 215. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80166-2_5

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