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HTLV-1 Oncoprotein Tax and Cellular transcription Factors

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Book cover Transacting Functions of Human Retroviruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 193))

Abstract

Human T cell leukemia virus (HTLV) type 1 (Poiesz et al. 1980; Yoshida et al. 1982) has two regulatory genes, tax and rex, that control the viral gene expression and replication positively and negatively (Seiki et al. 1983; Inoue et al. 1987; Hidaka et al. 1988). In these regulations, tax activates transcription of the viral genome, whereas rex modulates the processing of the viral RNA expressing unspliced forms of the viral mRNA; therefore, both regulators are indispensable for efficient viral replication.

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Author information

Authors and Affiliations

  1. Department of Cellular and Molecular Biology, Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, 108, Japan

    M. Yoshida, T. Suzuki, J. Fujisawa & H. Hirai

Authors
  1. M. Yoshida
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  2. T. Suzuki
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  3. J. Fujisawa
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  4. H. Hirai
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Editor information

Editors and Affiliations

  1. Division of Hematology/Oncology, 11-934 Factor, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA, 90024-1678, USA

    Irvin S. Y. Chen

  2. Department of Microbiology and Immunology Head of the Center of Neurovirology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA, 10107, USA

    Hilary Koprowski

  3. Department of Microbiology/Immunology Center for Neurovirology, Jefferson Medical College, Rm. 469 Jefferson Alumni Hall 1020 Locust Street, Philadelphia, PA, 19107-6799, USA

    Alagarsamy Srinivasan

  4. The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Peter K. Vogt

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© 1995 Springer-Verlag Berlin Heidelberg

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Yoshida, M., Suzuki, T., Fujisawa, J., Hirai, H. (1995). HTLV-1 Oncoprotein Tax and Cellular transcription Factors. In: Chen, I.S.Y., Koprowski, H., Srinivasan, A., Vogt, P.K. (eds) Transacting Functions of Human Retroviruses. Current Topics in Microbiology and Immunology, vol 193. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78929-8_4

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  • DOI: https://doi.org/10.1007/978-3-642-78929-8_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78931-1

  • Online ISBN: 978-3-642-78929-8

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