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Transplantation in Parkinson’s Disease

  • Conference paper
Restoration of Brain Function by Tissue Transplantation

Part of the book series: Basic and Clinical Aspects of Neuroscience ((BASIC,volume 5))

Abstract

The pathophysiologic process characteristic of Parkinson’s disease (PD) is a progressive degeneration of mesostriatal dopamine (DA) neurons that eventually causes motor symptoms, primarily tremor, rigidity, and hypokinesia. Despite the marked symptomatic relief initially provided by L-dopa treatment, there is in most patients with advanced PD a progressive loss of efficacy of the drug, associated with diurnal oscillations in motor performance (“on-off” phenomena) and dyskinesias. Even though patients often temporarily benefit from changes in medication, most of them become severely incapacitated. For this large group of patients new therapeutic approaches are needed.

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  1. Restorative Neurology Unit, Department of Neurology, University Hospital, Lund, Sweden

    P. Brundin & O. Lindvall

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  1. P. Brundin
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  2. O. Lindvall
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  1. Restorative Neurology Unit (RNU) Department of Neurology, University Hospital, 221 85, Lund, Sweden

    Olle Lindvall

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© 1993 Springer-Verlag Berlin Heidelberg

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Brundin, P., Lindvall, O. (1993). Transplantation in Parkinson’s Disease. In: Lindvall, O. (eds) Restoration of Brain Function by Tissue Transplantation. Basic and Clinical Aspects of Neuroscience, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77718-9_2

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  • DOI: https://doi.org/10.1007/978-3-642-77718-9_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55823-1

  • Online ISBN: 978-3-642-77718-9

  • eBook Packages: Springer Book Archive

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