Abstract
Cyclosporin A (CsA) is metabolized principally by the hepatic cytochrome P 450-dependent microsomal enzyme system and eliminated virtually entirely as metabolites, mainly in the bile [1, 4, 6]. Only less than 1% of the oral dose is excreted unmetabolized in the urine or bile [5, 7]. Metabolites account for 50–70% of the total CsA in whole blood [3, 5, 8]. Some of the metabolites have been shown to possess an immunosuppressive and even toxic effect but the role of this effect remains uncertain [2, 9].
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© 1992 Springer-Verlag Berlin Heidelberg
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Tötterman, A., Lalla, M., Salmela, K., Höckerstedt, K. (1992). Cholestasis and kidney dysfunction in liver transplant patients reduces cyclosporine metabolite excretion. In: Kootstra, G., Opelz, G., Buurman, W.A., van Hooff, J.P., MacMaster, P., Wallwork, J. (eds) Transplant International Official Journal of the European Society for Organ Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77423-2_59
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DOI: https://doi.org/10.1007/978-3-642-77423-2_59
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