Abstract
In summary, we established that a significant production of the monokines interleukin-6, tumor necrosis factor apha, and interleukin-1 occurred during orthotopic liver transplantation whereas the lymphokines interferon gamma and interleukin-2 were not detected. Levels of interleukin-6 reached their maximum values before and especially at the end of the anhepatic phase. They remained high after the anhepatic phase, i. e. after reper-fusion of the new livers. Tumor necrosis factor alpha and interleukin-1 reached their maximum values after the anhepatic phase. Not only were interleukin-6, tumor necrosis factor apha, and interleukin-1 present in the serum but they could also be detected in the bile produced by these new livers. Mechanisms of monokine production during orthotopic liver transplantation is multifactorial in origin and further studies will have to evaluate the relative contribution of the various factors involved. The possibility of an association between peroperative monokines and transplant outcome and their potential clinical implication will have to be elucidated.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Andus T, Bauer J, Gerok W (1991) Effects of cytokines on the liver. Hepatology 13:364–375
Caldwell-Kenkel JC, Currin RT, Tanaka Y, Thurman RG, Le-masters JJ (1990) Kupffer cell activation and endothelial cell damage after storage of rat livers: effects of reperfusion. Hepatology 13:83–95
Colletti LM, Remick DG, Burtch GD, Kunkel SL, Strieter RM, Campbell DA (1990) Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat. J Clin Invest 85:1936–1943
Colletti LM, Burtch GD, Remick DG, Kunkel SL, Strieter RM, Guice KS, Oldham KT, Campbell DA (1990) The production of tumor necrosis factor alpha and the development of a pulmonary capillary injury following hepatic ischemia/reperfusion. Transplantation 49:268–272
Damas P, Reuter A, Gysen P, Demonty J, Lamy M, Franchimont P (1989) Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans. Critical care. Medicine 17:975–978
Decker K (1990) Biologically active products of stimulated liver macrophages (Kupffer Cells). Eur J Biochem 192:245–261
Fugger R, Hamilton G, Steininger R, Mirza D, Schulz F, Muhlbacher F (1991) Intraoperative estimation of endotoxin, TNF and IL-6 in orthotopic liver transplantation and their relation to rejection and postoperative infection. Transplantation 52:302–306
Howard TK, Klintmalm GBG, Cofer JB, Husberg BS, Goldstein RM, Gonwa TA (1990) The Influence of preservation injury on rejection in the hepatic transplant recipient. Transplantation 49:103–107
Miyata T, Todo S, Imventarza O, Ueda Y, Furukawa H, Starzl TE (1989) Endogenous endotoxemia during orthotopic liver transplantation in dogs. Transplant Proc 21:3861–3862
Miyata T, Todo S, Selby R, Yokoyama I, Tzakis A, Starzl TE (1989) Endotoxaemia, pulmonary complications, and thrombocytopenia in liver transplantation. Lancet 1:189–191
Nishimoto N, Yoshizaki K, Tagoh H, Monden M, Kishimoto S, Hirano T, Kishimoto T (1989) Elevation of serum interleukin 6 prior to acute phase proteins on the inflammation by surgical operation. Clin Immunol Immunopathol 50:399–401
Rao PN, Liu T, Snyder JT, Piatt JL, Starzl TE (1991) Reperfusion injury following cold ischemia activates rat liver Kupffer cells. Transplant Proc 23:666–669
Tono T, Monden M, Yoshizaki K, Valdivia LA, Nakano Y, Gotoh M, Ohzato H, Doki Y, Ogata A, Kishimoto T, Mori T (1991) Interleukin 6 levels in bile following liver transplantation. Transplant Proc 23:630–631
Yokoyama I, Todo S, Miyata T, Selby R, Tzakis AG, Starzl TE (1989) Endotoxemia and human liver transplantation. Transplant Proc 21:3833–3841
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Pirenne, J. et al. (1992). Intraoperative cytokines production during orthotopic liver transplantation. In: Kootstra, G., Opelz, G., Buurman, W.A., van Hooff, J.P., MacMaster, P., Wallwork, J. (eds) Transplant International Official Journal of the European Society for Organ Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77423-2_186
Download citation
DOI: https://doi.org/10.1007/978-3-642-77423-2_186
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-55342-7
Online ISBN: 978-3-642-77423-2
eBook Packages: Springer Book Archive