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Trauma and Sepsis Induced Activation of Granulocytes, Monocytes/Macrophages and Endothelial Cells in Primates

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Abstract

In posttraumatic organ failure we distinguish two different phases -early and late organ failure —, which by definition are caused by non-bacterial (early) and bacterial products (late) induced generalized inflammation. Organ failure is the final result of the action of inflammatory mediators, which cause a permeability increase as well as cellular edema.

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References

  • Aarden LA, deGroot ER, Schaap OL, Landsdrop PM (1987) Production of hybridoma growth factor by human monocytes. Eur J Immunol 7: 1411–1414

    Article  Google Scholar 

  • Baggiolini M, Walz A, Kunkel SL (1989) Neutrophil activating peptide-1/interleukin-8 a novel cytokine that activates neutrophils. J Clin Invest 84: 1045–1049

    Article  PubMed  CAS  Google Scholar 

  • Besemer J, Hujber A, Kuhn B (1989) Specific binding internalization, and degradation of human neutrophil activating factor by human polymorphonuclear leukocytes. J Biol Chem 264: 17409–17415

    PubMed  CAS  Google Scholar 

  • Beutler B, Cerami A (1986) Cachectin and tumor necrosis factor as two sides of the same biological coin. Nture 320: 584–588

    Article  CAS  Google Scholar 

  • Blanchard DK, Djeu JY, Klein TW, Friedman H, Stewart WEH (1986) Interferon-gamma induction by lipopolysaccharide: dependence on interleukin 2 and macrophages. J Immunol 136: 963–970

    PubMed  CAS  Google Scholar 

  • Ceska M, Effenberger F, Peichl P, Pursch E (1989) Purification and characterization of monoclonal and polyclonal antibodies to neutrophil activation peptide (NAP-1). The development of highly sensitive ELISA-methods for the determination of NAP-1 and anti-NAP-1 antibodies. Posterpresentation 2nd International Workshop on Cytokines, Hilton Head, South Carolina, USA, December 1989.

    Google Scholar 

  • Cooper JA, Neumann PH, Wright SD, Malik AB (1989) Pulmonary vascular sequestration of neutrophil in edotoxemia: role of CD18 leukocyte surface glycoprotein. Am Thorac Soc — Abstract

    Google Scholar 

  • Dinarollo CA (1984) Interleukin 1 and the pathogenesis of the acute phase response. N Engl J Med 311: 1413–1418

    Article  Google Scholar 

  • Dreher M, Gunzer G, Helger R, Lang H (1989) An automated homogeneous enzyme immunoassay for human PMN elastase. In: Schlag G, Redl H (eds) “Progress in Clinical and Biological Research, Second Vienna Shock Forum, vol 308, Alan R Liss Inc, New York, p 707

    Google Scholar 

  • Duswald KH, Jochum M, Schramm W, Fritz H (1985) Released granulocytic elastase: an indicator of pathobiochemical alterations in septicemie after abdominal surgery. Surgery 98: 892–899

    PubMed  CAS  Google Scholar 

  • Fong Y, Tracey KJ, Moldawer LL, Hesse DG, Manogue KB, Kenney JS, Lee AT, Kuo GC, Allison AC, Lowry SF, Cerami A (1989) Antibodies to cachectin/tumor necrosis factor reduce interleukin-1 beta and interleukin-6 appearance during lethal bacteremia. J Exp Med 170: 1627–1633

    Article  PubMed  CAS  Google Scholar 

  • Forsyth KD, Simpson AC, Fitzpatrick MM, Barratt TM, Levisnkiy RJ (1989) Neutrophil mediated endothelial injury in haemolytic uraemic syndrome. Lancet II: 411–416

    Article  Google Scholar 

  • Fridman EP, Popova VN (1988) Species of the genus papio as subjects of biomedical research. II. Quantitative characteristics of contemporary use of baboon species in medical and biological investigations. J Med Primatol 17: 309–318

    PubMed  CAS  Google Scholar 

  • Gamble JR, Harlan JM, Klebanoff SJ, Vadas MA (1985) Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor. Proc Natl Acad Sci USA 82: 8667–8671

    Article  PubMed  CAS  Google Scholar 

  • Harlan JM (1987) Consequences of leukocytevessel wall interactions in inflammatory and immune reactions. Semin Thromb Hemost 13: 434–441

    Article  PubMed  CAS  Google Scholar 

  • Harlan JM, Killen PD, Snecal F, Schwartz BR, Yee EK, Taylor RF, Beatty PG, Price T, Ochs HD (1985) The role of neutrophil membrane glycoprotein GP-150 in neutrophil adherence to endothelium in vitro. Blood 66: 167–178

    PubMed  CAS  Google Scholar 

  • Herman CM, McKee AE, Schillings PW, Dickson LG, Horwitz DL, Coran AG, Cryer PE, Kopriva CJ (1972) The baboon as a subhuman primate shock model. In Forscher BK, Lillehei RC, Stubbs SS (eds) Shock in low-and high flow states, Proceedings of a symposium at brook lodge, Augusta, Michigan 1971, Excerpta Medica, Amsterdam, p 42

    Google Scholar 

  • Hesse DG, Traces KJ, Fong Y, Manogue KR, Palladino MAjr, Cerami A, Shires GT, Lowry SF (1988) Cytokine appearance in human endotoxemia and primate bacteremia. Surg Gynecol Obstet 166: 147–153

    PubMed  CAS  Google Scholar 

  • Kownatzki E, Kapp A, Uhrich S (1986) Novel neutrophil chemotatic factor derived from human peripheral blood mononuclear leucocytes. Clin Exp Immunol 64: 214–222

    PubMed  CAS  Google Scholar 

  • Lang, Jochum M, Fritz H, Redl H (1989) Validity of the elastase assay in intensive care medicine. In Schlag G, Redl H (eds) Progress in clinical and biological research, second Vienna shock forum, vol. 308, Alan R Liss Inc, New York, p 701

    Google Scholar 

  • Larrick JW, Graham D, Toy K, Lin LS, Senyk G, Fendly BM (1987) Recombinant tumor necrosis factor causes activation of human granulocytes. Blood 69: 640–644

    PubMed  CAS  Google Scholar 

  • Larsen CG, Anderson AO, Oppenheim JJ, Matsushima K (1989) Production of interleukin-8 by human dermal fibroblasts and keratinocytes in response to interleukin 1 or tumor necrosis factor. Immunology 68: 31–36

    PubMed  CAS  Google Scholar 

  • Leeuwenberg FM, Jeunhomme TMAA, Buurman WA (1989) Induction of an activation antigen on human endothelial cells in vitro. Eur J Immunol 19: 715–720

    Article  PubMed  CAS  Google Scholar 

  • Marinkovic S, Jahreis GP, Wong GG, Baumann H (1989) IL-6 modulates the synthesis of a specific set of acute phase plasma proteins in vivo. J Immunol 142: 808–812

    PubMed  CAS  Google Scholar 

  • Neumann S, Gunzer G, Hennrich N, Lang H (1984) “PMN elastase assay”: enzyme immunoassay for human polymorphonuclear elastase complexed with alpha-1 proteinase inhibitor. J Clin Chem Clin Biochem 22: 693–697

    PubMed  CAS  Google Scholar 

  • Nuytinck JKS; Goris RJA, Redl H, Schlag G, van Munster PJJ (1986) Posttraumatic complications and inflammatory mediators. Arch Surg 121: 886–890

    Article  PubMed  CAS  Google Scholar 

  • Oppenheim JJ, Matsushima K, Yoshimura T, Leonard EJ, Neta R (1989) Relationship between interleukin (IL-1), tumor necrosis factor (TNF) and a neutrophil attracting peptide (NAP-1). Agent Action 26:134–140

    Article  CAS  Google Scholar 

  • Pacher R, Redl H, Frass M, Petzl DH, Schuster E, Woloszczuk W (1989) Relationship between neopterin and granulocyte elastase plasma levels and the severity of multiple organ failure. Crit Care Med 17: 221–226

    Article  PubMed  CAS  Google Scholar 

  • Pober JS (1988) Cytokine-mediated activation of vascular endothelium. Phyisology and pathology. Am J Pathol 133: 426–431

    PubMed  CAS  Google Scholar 

  • Pober JS, Bevilacqua MP, D.L. Mendrick DL, Lapierre LA, Fiers W, Gimbrone MAjr (1986a) Two distinct monokines, interleukin 1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells. J Immunol 136: 1680–1687

    PubMed  CAS  Google Scholar 

  • Pober JS, Gimbrone MAjr, Lappierre LA, Mendrick DL, Fiers W, Rothlein R, Springer TA (1986b) Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. J Immunol 137: 1893–1896

    PubMed  CAS  Google Scholar 

  • Pretorius JP, Schlag G, Redl H, Botha WS, Goosen DJ, Bosman H, Eeden van AF (1987) The ‘lung in shock’ as a result of hypovolemic-traumatic shock in baboons. J Trauma 27: 1344–1352

    Article  PubMed  CAS  Google Scholar 

  • Redl H, Schlag G, Dinges HP, Buurman W, Rothlein R, Pober J, Cotran R (1990a) Endothelial activation after polytrauma and sepsis in the baboon. Circ Shock 31: 79

    Google Scholar 

  • Redl H, Schlag G, Dinges HP, Buurman W, van der Linden CJ, Pober J, Cotran R (1990) Endothelial cell activations in septic but not traumatic shock whereas neutrophils are activated in both settings. Am J Pathol: submitted

    Google Scholar 

  • Redl H, Schlag G, Hammerschmidt DE (1984) Quantitative assessment of leukostasis in experimental hypovolemic-traumatic shock. Acta Chir Scand 150: 113–117

    PubMed  CAS  Google Scholar 

  • Redl H, Schlag G, Lamche H, with technical assistance of Vogl C, Paul E, Schießer A, Wilfing C, Thurnher M and the Biomedical Engineering Group (1990b) TNF- and LPS-induced changes of lung vascular permeability: studies in unanesthetised sheep. Circ Shock 31: 183–192

    PubMed  CAS  Google Scholar 

  • Redl H, Schlag G, Paul E, Davies J (1989) Monocyte/ macrophage activation with cytokine release after polytrauma and sepsis in the baboon. Circ Shock 27: 308

    Google Scholar 

  • Schlag G, Redl H (1985a) Morphology of the human lung after traumatic injury. In Zapol EM, Falke KJ (eds) Acute respiratory failure. Marcel Dekker Inc, New York, Basel, p 161

    Google Scholar 

  • Schlag G, Redl H (1985b) Morphology of the microvascular system in shock: Lung, liver and skeletal muscle. Crit Care Med 13: 1045–1049

    PubMed  CAS  Google Scholar 

  • Schlag G, Redl H (1989a) Lung in shock — posttraumatic lung failure (organ failure) — MOFS. In Schlag G, Redl H (eds) Progress in clinical and biological research, second Vienna shock forum, Vol 308. Alan R Liss Inc, New York, p 3

    Google Scholar 

  • Schlag G, Redl H, Hallström S, Radmore K, Davies J (1990a) Hyperdynamic sepsis in baboons — I. Aspects of hemodynamics and oxygen transport. Circ Shock in press

    Google Scholar 

  • Schlag G, Redl H, Dinges HP, Davies J, Radmore K (1990b) Bacterial translocation in a baboon model of hypovolemic-traumatic shock. In: Schlag G, Redl H, Siegel JH (eds) Shock, Sepsis and Organ Failure, Second Wiggers Bernard Conference, Springer-Verlag, Berlin-Heidelberg, in press

    Chapter  Google Scholar 

  • Schlag G, Redl H, Radmore K, Davies J (1989b) Bacterial translocation in a baboon model of hypovolemic-traumatic shock. Circ Shock 27: 321

    Google Scholar 

  • Schröder JM, Mrowietz U, Morita E, Christofers E (1987) Purification and partial biochemical characterization of a human monocyte derived neutrophil activating peptide that lacks interleukin-1 activity. I Immunol 139: 3474–3479

    Google Scholar 

  • Shalaby MR, Waage A, Aarden L, Espevik T (1989) Endotoxin, tumor necrosis factor-alpha and interleukin 1 induce interleukin 6 production in vivo. Clin Immunol Immunopathol 53: 488–492

    Article  PubMed  CAS  Google Scholar 

  • Strieter RM, Phan SH, Showell HJ, Remick DG, Lynch JP, Genord M, Raiford C, Eskandari M, Marks RM, Kunkel SL (1989) Monokine-induced neutrophil chemotactic factor gene expression in human fibroblasts. J Biol Chem 264: 10621–10626

    PubMed  CAS  Google Scholar 

  • Tracey KJ, Fong Y, Hesse DG, Manogue KR, Lee AT, Kuo GC, Lowry SF, Cerami A (1987) Anti cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteremia. Nature 33: 662–664

    Article  Google Scholar 

  • Vedder NB, Fouty BW, Winn RK, Harlan JM, Rice CL (1989) Role of neutrophils in generalized reperfusion injury associated with resuscitation from shock. Surgery 106: 509–516

    PubMed  CAS  Google Scholar 

  • Waage A, Brandtzaeg P, Halstensen A, Kierulf P., Espevik T (1989) The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin-6, interleukin-1, and fatal outcome. J Exp Med 169: 333–338

    Article  PubMed  CAS  Google Scholar 

  • Walz A, Peveri P, Aschauer H, Baggiolini M (1987) Purification and amino acid sequencing of NAF, a novel neutrophil-activating factor produced by monocytes. Biochem Biophys Res Commun 149: 755–762

    Article  PubMed  CAS  Google Scholar 

  • Yoshimura T, Matsushima K, Tanaka S, Robinson EA, Appela E, Oppenheim JJ, Leonard EJ (1987) Purification of a human monocyte-derived neutrophil chemotactic factor that shars sequence homologty with other host defense cytokines. Proc Natl Acad Sci USA 84: 9233–9237

    Article  PubMed  CAS  Google Scholar 

  • Zabel P, Schönharting MM, Wolter DT, Schade U (1989) Oxpentifylline in endotoxemia. Lancet II: 1474–1477

    Article  Google Scholar 

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© 1991 Springer-Verlag Berlin, Heidelberg

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Redl, H. et al. (1991). Trauma and Sepsis Induced Activation of Granulocytes, Monocytes/Macrophages and Endothelial Cells in Primates. In: Schlag, G., Redl, H., Siegel, J.H., Traber, D.L. (eds) Shock, Sepsis, and Organ Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76511-7_12

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  • DOI: https://doi.org/10.1007/978-3-642-76511-7_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53831-8

  • Online ISBN: 978-3-642-76511-7

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