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Metal Antitumor Compounds: The Mechanism of Action of Platinum Complexes

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Ruthenium and Other Non-Platinum Metal Complexes in Cancer Chemotherapy

Part of the book series: Progress in Clinical Biochemistry and Medicine ((PCBM,volume 10))

Abstract

Cisplatin (cis-diamminedichloroplatinum(II)) is widely used in the treatment of testicular and ovarian cancers. A number of biological and biochemical results indicate that the reaction of cisplatin with DNA is responsible for the cytotoxic action of this drug. The effect of platinum compounds on the conformation and stability of DNA has been investigated and several platinum-DNA adducts have been identified in vitro and in vivo. Preliminary experiments have quantified the effect of these different lesions on DNA replication, their capacity to induce mutations and their susceptibility to DNA repair processes. Additional DNA damage may be created by platinum(IV) compounds, perhaps during their reduction to platinum(II) compounds by the cell.

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Authors and Affiliations

  1. Laboratoire de Pharmacologie et de Toxicologie Fondamentales, CNRS, 205, Route de Narbonne, Toulouse, 31077, France

    Neil P. Johnson, Jean-Luc Butour, Giuseppe Villani, Franz L. Wimmer, Martine Defais & Veronique Pierson

  2. Institute of Biophysics, Czechoslovak Academy of Sciences, Kralovopolska 135, Brno 12, Czechoslovakia

    Viktor Brabec

Authors
  1. Neil P. Johnson
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  2. Jean-Luc Butour
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  3. Giuseppe Villani
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  4. Franz L. Wimmer
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  5. Martine Defais
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  6. Veronique Pierson
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  7. Viktor Brabec
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Editor information

Editors and Affiliations

  1. Département de Chimie Biologique, Faculté de Médecine de Bicêtre, Université de Paris Sud, Hôpital de Bicêtre, F-94270, Bicêtre, France

    Etienne Baulieu

  2. Department of Pathology, School of Medicine, University of North Carolina, Chapel Hill, NC, 27514, USA

    Donald T. Forman

  3. Karolinska Institutet Institutionen för Medicinsk Kemi, Box 60400, S-104 01, Stockholm, Sweden

    Magnus Ingelman-Sundberg

  4. Institut für Biochemie, Universität Köln, An der Bottmühle 2, D-5000, Köln, Germany

    Lothar Jaenicke

  5. Sunnybrook Medical Centre, University of Toronto, 2075 Bayview Avenue, M4N 3M5, Toronto, Ontario, Canada

    John A. Kellen

  6. Department of Biochemistry Faculty of Medicine, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan

    Yoshitaka Nagai

  7. Immunochemistry Research, Evanston Hospital, Northwestern University, 2650 Ridge Avenue, 60201, Evanston, IL, USA

    Georg F. Springer

  8. Klinikum der Johann Wolfgang Goethe-Universität, Gustav-Embden-Zentrum, Theodor Stern Kai 7, D-6000, Frankfurt a. M. 70, Germany

    Lothar Träger

  9. Zentralinstitut für Herz- und Kreislauf-Forschung, Akademie der Wissenschaften der DDR, Lindenberger Weg 70, DDR-1115, Berlin-Buch, Germany

    Liane Will-Shahab

  10. Hormone Receptor Laboratory, James Graham Brown Cancer Center, University of Louisville, 40292, Louisville, KY, USA

    James L. Wittliff

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© 1989 Springer-Verlag Berlin Heidelberg

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Johnson, N.P. et al. (1989). Metal Antitumor Compounds: The Mechanism of Action of Platinum Complexes. In: Baulieu, E., et al. Ruthenium and Other Non-Platinum Metal Complexes in Cancer Chemotherapy. Progress in Clinical Biochemistry and Medicine, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74760-1_1

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  • DOI: https://doi.org/10.1007/978-3-642-74760-1_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74762-5

  • Online ISBN: 978-3-642-74760-1

  • eBook Packages: Springer Book Archive

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