Abstract
Lefetamine, a diphenylalkylaminic derivative, is a centrally acting analgesic which seems to possess abuse liability. The analgesic effect and the abuse liability of this compound are both due to its opiate activity. Lefetamine is an opiate agonist with an affinity for opiate receptors 50 times lower than that of morphine (De Montis et al 1985). Since genetic factors play a critical role in modulating some effects of morphine, the purpose of the present study was to investigate the effects of lefetamine on behavioural and neurochemical parameters in two inbred strains of mice (C57 BL/6J and DBA/2J) showing different responses to morphine (Oliverio and Castellano 1974; Cuomo et al 1981, 1981a).
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References
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© 1989 Springer-Verlag Berlin Heidelberg
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Cagiano, R. et al. (1989). Behavioural and Neurochemical Changes Produced by Lefetamine in Two Inbred Strains of Mice. In: Chambers, P.L., Chambers, C.M., Greim, H. (eds) Biological Monitoring of Exposure and the Response at the Subcellular Level to Toxic Substances. Archives of Toxicology, vol 13. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74117-3_73
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DOI: https://doi.org/10.1007/978-3-642-74117-3_73
Publisher Name: Springer, Berlin, Heidelberg
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