Abstract
Recombinant DNA techniques have enabled the production of highly purified species-specific proteins. A number of natural endogenous human proteins have become available for preclinical studies in non-homologous animal species. However, such drugs may cause formation of neutralizing antibodies (Teelman et al 1986). Immunologically incompetent animals could be used as a model for testing. One prerequisite for their usage as test model would be that they respond with toxicological manifestations similar to those seen in conventional animals.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Biber TUL, Mylle M, Baines AD, Gothschalk CN, Oliver JR, MacDowell MC (1968). A Study in micropuncture and microdissection of acute renal damage in rats. Am J Med 44: 664–705
Davis DC, Potter WZ, Jollow DJ, Mitchel JR (1974) Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen. Life Sci 14: 2099–2109
Freudenthal RI, Leber AP, Emmerling DC, Kerchner GA, Ovejera AA (1976) Comparison of the drug metabolizing enzymes in the liver and kidneys from homozygous nude Swiss, heterozygous normal Swiss, homozygous normal Swiss and DBA/2 mice. Res Comm Chem Path Pharmacol 15: 267–278
Litterst CL, Sikic BJ, Mimnaugh EG, Gaurino AM, Gram TE (1978) In vitro drug metabolism in male and female athymic, nude mice. Life Sci 22: 1723–1730
Mitchell JR, Jollow DJ, Potter WZ, Davis DC, Gilette JR, Brodie BB (1973) Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. J Pharmac Exp Ther 187: 185–194
Poulsen HE, Lerche A, Pedersen NT (1985) Phénobarbital induction does not potentiate hepa-totoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat. Pharmacology 30: 100–108
Teelman K, Hohbach C, Lehman H, The International Working Group (1986) Preclinical safety testing of species-specific proteins produced with recombinant DNA-techniques. An attempt to transfer current experience into future testing strategies. Arch Toxicol 59: 195–200
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Svendsen, O., Christensen, H.B., Rygaard, J., Juul, P. (1989). Comparative Study on the Toxicity of Acetaminophen and Mercuric Chloride in Normal and Athymic Mice and Rats. In: Chambers, P.L., Chambers, C.M., Greim, H. (eds) Biological Monitoring of Exposure and the Response at the Subcellular Level to Toxic Substances. Archives of Toxicology, vol 13. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74117-3_28
Download citation
DOI: https://doi.org/10.1007/978-3-642-74117-3_28
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-50336-1
Online ISBN: 978-3-642-74117-3
eBook Packages: Springer Book Archive