Abstract
Methyl chloride is enzymatically conjugated with glutathione in human erythrocytes; the S-methyl glutathione thus formed is not released by the cells (Redford-Ellis et al 1971). S-methyl cysteine, the metabolic product of methyl chloride, is excreted in the urine of workers exposed to the substance (van Doom et al 1980).
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Doom R van, Borm PJA, Leijdekkers Ch-M, Henderson PTh, Reuvers J, Bergen TJ van (1980) Detection and identification of S-methyl cysteine in urine of workers exposed to methyl chloride. Int Arch Occup Environ Health 46: 99–109
Guthenberg C, Mannervik B (1981) Glutathione S-transferase (transferase π) from human placenta is identical or closely related to glutathione S-transferase (transferase ρ) from erythrocytes. Biochem Biophys Acta 661: 255–260
Hussey AJ, Hayes JD, Beckett GJ (1987) Measurement of human neutral glutathione S-transferase (GST) concentration in plasma and biopsy tissue using radioimmunoassay, in: Glutathione S-transferases and carcinogenesis (TJ Mantle, CB Pickett, JD Hayes eds), Taylor & Francis, London, N. Y. and Philadelphia, pp 39–40
Marcus CJ, Habig WH, Jacoby WB (1978) Glutathione transferase from human erythrocytes. Arch Biochem Biophys 188: 287–293
Redford-Ellis M, Gowenlock AH (1971) Studies on the reaction of chloromethane with human blood. Acta Pharmacol et Toxicol 30: 36–48
Stewart RD, Hake CL, Wu A, Graff SA, Forster HV, Keeler WH, Lebrun AJ, Newton PE, Soto RJ (1977) Methyl chloride: Development of a biologic standard for the industrial worker by breath analysis. Report no NIOSH-MCOW-ENVM-MCM-77–1
Suzuki T, Coggan M, Shaw DC, Board PG (1987) Electrophoretic and immunological analysis of human glutathione S-transferase isoenzymes. Ann Hum Genet 51: 95–106
Warholm M, Guthenberg C, Mannervik B (1983) Molecular and catalytic properties of glutathione transferase μ from human liver: an enzyme efficiently conjugating epoxides. Biochemistry 22: 3610–3617
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© 1989 Springer-Verlag Berlin Heidelberg
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Peter, H., Deutschmann, S., Muelle, A., Gansewendt, B., Bolt, M., Hallier, E. (1989). Different Affinity of Erythrocyte Glutathione-S-Transferase to Methyl Chloride in Humans. In: Chambers, P.L., Chambers, C.M., Greim, H. (eds) Biological Monitoring of Exposure and the Response at the Subcellular Level to Toxic Substances. Archives of Toxicology, vol 13. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74117-3_17
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DOI: https://doi.org/10.1007/978-3-642-74117-3_17
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