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Influence of Inhibitors on the Thrombogenicity and Toxicity of Prothrombin Complex Concentrates

  • Conference paper
Mechanisms and Models in Toxicology

Part of the book series: Archives of Toxicology, Supplement ((TOXICOLOGY,volume 11))

  • 177 Accesses

Abstract

Patients treated with prothrombin complex concentrates (PCCs) have frequently been found to develop arterial thrombosis, venous thromboembolism or disseminated intravascular coagulation (Kasper 1975). Consequently, PCCs must be regarded as potentially thrombogenic substances (Elodi 1977). Within the framework of studies of a new PCC (Klöcking et al. 1984), the influence of heparin, pentosan polysulphate and synthetic thrombin inhibitors on the thrombogenicity of PCCs was examined. Furthermore, the effect of heparin, pentosan polysulphate or aprotinin was studied on the acute toxicity of PCC and on that observed after 7 days.

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References

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Author information

Authors and Affiliations

  1. Institute of Pharmacology and Toxicology, Medical Academy Erfurt, Nordhäuser Str. 74, 5010, Erfurt, Germany

    H.-P. Klöcking, G. Dornheim & H. Schulze-Riewald

Authors
  1. H.-P. Klöcking
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  2. G. Dornheim
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  3. H. Schulze-Riewald
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

    Claire M. Chambers  & Philip L. Chambers  & 

  2. Royal Postgraduate Medical School, Du Cane Road, W12 OHS, London, UK

    Donald S. Davies

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© 1987 Springer-Verlag

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Klöcking, HP., Dornheim, G., Schulze-Riewald, H. (1987). Influence of Inhibitors on the Thrombogenicity and Toxicity of Prothrombin Complex Concentrates. In: Chambers, C.M., Chambers, P.L., Davies, D.S. (eds) Mechanisms and Models in Toxicology. Archives of Toxicology, Supplement, vol 11. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72558-6_60

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  • DOI: https://doi.org/10.1007/978-3-642-72558-6_60

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17614-5

  • Online ISBN: 978-3-642-72558-6

  • eBook Packages: Springer Book Archive

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